Multi-biomarker approach to evaluate the neurotoxic effects of environmentally relevant concentrations of phenytoin on adult zebrafish Danio rerio

Cardoso-Vera, Jesús Daniel; Gómez-Oliván, Leobardo Manuel; Islas-Flores, Hariz; García-Medina, Sandra; Elizalde-Velázquez, Gustavo Axel; Orozco-Hernández, José Manuel; Heredia-García, Gerardo; Rosales-Pérez, Karina Elisa; Galár-Martínez, Marcela

doi:10.1016/j.scitotenv.2022.155359

Cited by 7 publications

(4 citation statements)

References 66 publications

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“…Additionally, enzyme activity analysis indicated a decrease in sod activity following treatment with photoaged polystyrene ( Ding et al, 2023 ), bisphenol A ( Gu et al, 2021 ), acrylamide ( Haridevamuthu et al, 2022 ), and AlCl3 ( Haridevamuthu et al, 2023 ). Conversely, other neurotoxicity studies reported an increase in sod activity following treatment with venlafaxine ( Alves et al, 2023 ), phenytoin ( Cardoso-Vera et al, 2022 ), and lincomycin hydrochloride ( Cheng et al, 2020 ).…”

Section: Oxidative Stressmentioning

confidence: 97%

“…The specific behaviour observed may depend on the neurotoxic agent used. For instance, a reduction in time spent in the upper area of the tank was observed following the administration of metformin ( Elizalde-Velazquez et al, 2022a ), methamphetamine ( Bedrossiantz et al, 2021 ), acrylamide ( Faria et al, 2018 ; Faria et al, 2019b ) and silica nanoparticles ( Li et al, 2020 ), while an increase in upper area exploration was observed with phenytoin ( Cardoso-Vera et al, 2022 ) and guanylurea ( Elizalde-Velazquez et al, 2022b ). Interestingly, thermal treatments also influenced zebrafish behaviour in NTT, showing opposite effects at low and high temperatures.…”

Section: Behaviourmentioning

confidence: 99%

See 1 more Smart Citation

Temperature- and chemical-induced neurotoxicity in zebrafish

Toni,

Arena,

Cioni

et al. 2023

Front. Physiol.

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Throughout their lives, humans encounter a plethora of substances capable of inducing neurotoxic effects, including drugs, heavy metals and pesticides. Neurotoxicity manifests when exposure to these chemicals disrupts the normal functioning of the nervous system, and some neurotoxic agents have been linked to neurodegenerative pathologies such as Parkinson’s and Alzheimer’s disease. The growing concern surrounding the neurotoxic impacts of both naturally occurring and man-made toxic substances necessitates the identification of animal models for rapid testing across a wide spectrum of substances and concentrations, and the utilization of tools capable of detecting nervous system alterations spanning from the molecular level up to the behavioural one. Zebrafish (Danio rerio) is gaining prominence in the field of neuroscience due to its versatility. The possibility of analysing all developmental stages (embryo, larva and adult), applying the most common “omics” approaches (transcriptomics, proteomics, lipidomics, etc.) and conducting a wide range of behavioural tests makes zebrafish an excellent model for neurotoxicity studies. This review delves into the main experimental approaches adopted and the main markers analysed in neurotoxicity studies in zebrafish, showing that neurotoxic phenomena can be triggered not only by exposure to chemical substances but also by fluctuations in temperature. The findings presented here serve as a valuable resource for the study of neurotoxicity in zebrafish and define new scenarios in ecotoxicology suggesting that alterations in temperature can synergistically compound the neurotoxic effects of chemical substances, intensifying their detrimental impact on fish populations.

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Section: Oxidative Stressmentioning

confidence: 97%

Section: Behaviourmentioning

confidence: 99%

Temperature- and chemical-induced neurotoxicity in zebrafish

Toni,

Arena,

Cioni

et al. 2023

Front. Physiol.

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“…[12][13][14] For example, Cardoso-Vera's group demonstrated that an environmentally relevant concentration of PHT may induce oxidative stress in zebrash embryos and brains of adult zebrash, and increase the acetylcholinesterase level in adult zebrash, thus affecting the embryonic development of zebrash or triggering a harmful response in the brain of adult zebrash. 15,16 Another report showed that PHT and LTG in treated wastewater may induce a stress response in tomato plants. 17 Unchanged forms of PHB excreted through the kidney can contribute to aquatic contamination and potential damage to human health and the environment.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of a surface molecularly imprinted polymer membrane based on a single template and its application in the separation and extraction of phenytoin, phenobarbital and lamotrigine

Zhao,

You,

Chen

et al. 2024

RSC Adv.

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“…26 Acetylcholinesterase (AChE) is a neurotransmitter which plays an important role in neural system-related activities in zebrafish. 27 ROS have a significant role in zebrafish embryonic development since they could alter signal transduction pathways during developmental stages. 28 The antioxidant defence system has many enzymatic and non-enzymatic antioxidants to maintain/neutralize excessive ROS.…”

Section: Introductionmentioning

confidence: 99%