Multi-biofunctional complexes combining antiseptic copper(II) with antibiotic sulfonamide ligands: Structural, redox and antibacterial study

Synthesis, spectroscopic characterization, antimicrobial activity and crystal structure of silver and copper complexes of sulfamethazine

“…The distance between copper and nitrogen adjacent to the sulfonyl group for the first molecule [Cu1-N11 = Cu1-N11 i = 2.4769(18) Å] and for the second molecule [Cu2-N21 = Cu2-N21 i = 2.0280(18) Å] are similar to previously reported distances inother Cu-N systems[37,38]. Third and fourth bonds involve the pyrimidine nitrogens for the first molecule [Cu1-N12 = Cu1-N12 i = 2.0076(19) Å] and for the second molecule [Cu2-N22 = Cu2-N22 i = 2.629(19) Å], which are similar to those reported for copper complexes of sulfamethazine[18,19]. Fifth and sixth bonds involve the pyridine nitrogens for the first molecule [Cu1-N15 = Cu1-N15 i = 2.055(2) Å] and for the second molecule [Cu2-…”

“…The phenyl ring is vertical to the pyrimidine ring with a dihedral angle of 81. 35 (1) The bond lengths and angles of the phenyl ring conform well to those found in the free sulfamethazine [11,12], whereas distances S1-N1 (1.5980 (19) Å for the first molecule and 1.5996 (19) Å for the second molecule) and N11-C31 (1.364(3) Å for the first molecule and 1.377(3) Å for the second molecule) are shorter in the copper complex than those in free sulfamethazine [11,12]. The stereochemistry about sulfur is a slightly distorted tetrahedral geometry with the bond lengths and angles involving sulfur lying within the range quoted in the literature [33][34][35].…”

“…Recently, the crystal structures of octahedral Cu(II) [19], Zn(II), and Cd(II) sulfamethazine [20] complexes, prepared from the acid form in presence of ammonia as a deprotonating agent, showed an important aspect in which the coordination sphere is formed from pyrimidine, and sulfonamidic nitrogen of two sulfa ligands, water, and the terminal amino of a third sulfa ligand.…”

Role of [FeOx(OH)y] surface sites on the adsorption of β-lactamic antibiotics on Al2O3 supported Fe oxide

“…Several reports in coordination biochemistry have shown that soluble iron and other transition metals can complex antibiotic molecules [24][25][26]. Amoxicillin, for example, is reported to form complexes with aqueous Fe(II), Fe(III), Co(II), Co(III), Ni(II), Cu(II) and Zn(II) [27], and La(III), Ce(III), Sm(III) and Y(III) [26,27].…”

Synthesis and Antimicrobial Activity of Novel Heterocyclic Sulfamoyl‐phenyl‐carboximidamides Derived from Clinically Applied Sulfonamides

“…In fact, they exhibit diverse pharmacological activities including carbonic anhydrase inhibitors [9], diabetes [10], antifungal [11], antiviral [12], anticancer and anti-inflammatory [13], and antibacterial activities. Such complexes exhibit interesting antibacterial and antifungal properties [14][15][16]. 1) belong to this chemical group.…”