Multi analyte sensing of amphiphilic tridentate bis(benzimidazolyl)pyridine incorporated in liposomes and potential application in enzyme assay

Cyanine dye‐based new amphiphilic compound NIR‐Amp has been synthesised. NIR‐Amp was embedded with phospholipids DOPC and DPPC to form liposomes based nanoscale chemical sensors NIR‐Lip1 and NIR‐Lip2. Here, two different phospholipids were used to demonstrate the influence of lipid structure, composition and fluidity on sensing of nanosensors. Both the probes show NIR absorption maximum at 790 nm and emission maximum at 815 nm. H2S‐triggered thiolation resulted a remarkable change in color from green to pale yellow. A decrease in UV‐Vis absorption and emission in the NIR region observed only with H2S. NIR‐Lip1 and NIR‐Lip2 are highly selective for H2S with a LOD of 0.57 µM and 1.24 µM, respectively. It was observed that in a solid‐like gel state, NIR‐Lip1 is slightly more sensitive towards H2S than fluid‐like NIR‐Lip2. The H2S sensing mechanism was confirmed by ESI‐mass and infrared (IR) spectroscopic analysis. Based on the high sensitivity and selectivity, NIR‐Lip1 was employed to detect H2S in vegetable samples. Further, the probes are found to be non‐toxic and established for H2S fluorescence imaging in live cells

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Liposome Based Near‐Infrared Sensors for the Selective Detection of Hydrogen Sulfide

Kumar

Sakla

Sharma

et al. 2023

ChemPlusChem

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Naphthalimide-based light-induced nitric oxide-releasing nanoscale vesicles with visual detection and cytotoxicity studies

Kumar,

Kanika,

Nitin

et al. 2024

iScience

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Aggregation-induced emission active multianalyte sensor: Detection of pH, carbonate, bi-carbonate and nitroaromatics in water

Gadiyaram,

Ghosh,

Ghule

et al. 2024

Microchemical Journal

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Multi analyte sensing of amphiphilic tridentate bis(benzimidazolyl)pyridine incorporated in liposomes and potential application in enzyme assay

Abstract: Liposome based nanosensor Lipo-1 for efficient detection of copper, cyanide (CNˉ) and ATP in pure aqueous medium has been described. Lipo-1 shows fluorescence ON-OFF response with copper. However, Lipo-1.Cu (Lipo-1...

Cited by 6 publications

References 40 publications

Liposome Based Near‐Infrared Sensors for the Selective Detection of Hydrogen Sulfide

Liposome Based Near‐Infrared Sensors for the Selective Detection of Hydrogen Sulfide

Naphthalimide-based light-induced nitric oxide-releasing nanoscale vesicles with visual detection and cytotoxicity studies

Aggregation-induced emission active multianalyte sensor: Detection of pH, carbonate, bi-carbonate and nitroaromatics in water

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