Müllerianosis of the urinary bladder: a rare and problematic bladder tumour

Patel, Amit; Desai, Pranali; Malczewski, Frances; Stephens, Daryl

doi:10.1136/bcr-2016-218772

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…However, lesions in a virgin abdomen or lesions containing multiple cell types are difficult to explain with this theory. 2,4 Oliva et al reviewed 13 patients with CCC of the urinary bladder in order to study the origin, and could not identify histopathological or immunohistochemical markers to distinguish Mullerian or transitional cell origin. 5 Our patient had a history of previous surgery, and so the theory of implantation might be a plausible explanation.…”

Section: Discussionmentioning

confidence: 99%

Clear cell carcinoma of Mullerian origin in the urinary bladder: A rare entity

Garg

Nayak

Nakra

et al. 2021

Journal of Clinical Urology

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Mullerian neoplasms of the urinary system are rare but complex tumor-like lesions. The identification of the Mullerian neoplasm is crucial for patient management owing to its etiology, natural history, and prognosis. We present a case of a 42-year-old female with a history of three lower segment cesarean sections presenting with complaints of dysmenorrhea and suprapubic pain with no history of hematuria or any urinary symptoms. Magnetic resonance imaging revealed a 2 cm×2 cm exophytic lesion suspicious of being either a bladder lesion or an endometrial lesion infiltrating the urinary bladder. Cystoscopy and transurethral biopsy of this suspicious bladder tumor revealed a malignant tumor with papillary and tubulocystic architecture. Based on the overall histomorphological and immunohistochemical features, a diagnosis of clear cell carcinoma of Mullerian origin was made, and the patient underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy and partial cystectomy. The patient was kept on regular surveillance and showed no signs of recurrence at the one-year follow-up. Clear cell carcinoma of the bladder of Mullerian origin is a rare entity and is established on histopathology. Prompt diagnosis and a multidisciplinary approach are indispensable for management. Level of evidence: Level 4.

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Section: Discussionmentioning

confidence: 99%

Clear cell carcinoma of Mullerian origin in the urinary bladder: A rare entity

Garg

Nayak

Nakra

et al. 2021

Journal of Clinical Urology

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“…Regardless of the lack of consensus on the choice of therapy, most physicians and patients chose the surgical intervention in the reported cases, and most of the patients had a favorable prognosis. Sixteen patients underwent TURBT, only five of whom required subsequent medical treatment, [12,13] or partial cystectomy [16,18,19] due to persistent symptoms or tumor recurrence. None of the four patients who underwent partial cystectomy had recurrence; by contrast, in two cases using gonadotropin-releasing hormone (GnRH) analogues to inhibit pituitary and gonadal function to reduce the tumor volume as medical treatment, cystoscopy showed smaller but persistent tumors at 3 months and 2 years of follow up.…”

Section: Discussionmentioning

confidence: 99%

Concurrent müllerianosis of the urinary bladder and the umbilicus presenting with umbilical bleeding: a rare case report and review of the literature

Jhang

Chen

2020

BMC Women's Health

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Background: Müllerianosis is a very rare neoplasm composed of two or three Müllerian derived tissues (endosalpinx, endometrium and endocervix). We report the first case of concurrent müllerianosis of the urinary bladder and the umbilicus presenting with umbilical bleeding. Case presentation: A 43-year-old Asian premesopausal female, gravida 1, para 1, presented with intermittent umbilical bleeding. An umbilical nodule and a bladder tumor on the posterior wall of the urinary bladder were identified. She underwent transurethral resection of the bladder tumor and excision of the umbilical nodule successively. Diagnosis of müllerianosis was confirmed by the histological and immunological features. No tumor recurrence was noted at 6 months of follow-up. Conclusions: Müllerianosis is extremely rare and mainly reported in the urinary bladder, and generally affects women of reproductive age. Despite the common presentations of müllerianosis of the urinary bladder including irritative voiding symptoms, abdominal/pelvic pain and gross hematuria, our rare case had no symptom except umbilical bleeding. The possibility of concurrent bladder müllerianosis should be considered when müllerianosis is found at other location. We suggest a surgical intervention to establish the correct pathological diagnosis because it is essential to exclude malignant neoplasms of the urinary bladder. The majority of patients have a favorable prognosis.

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“…Less than thirty cases of this entity are described in English literature till date. 1 The enigma of Mullerianosis is that it mimics a neoplastic bladder lesion clinically, cytologically and well as histologically. The rarity contributes to misdiagnosis.…”

Section: Introductionmentioning

confidence: 99%

Mullerianosis of Urinary Bladder: A Great Impersonator of Malignant Urinary Bladder Tumours

Darakh¹,

Patil²,

Mahajan³

2018

IJCMR

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Introduction: Mullerianosis of urinary bladder is an enigmatic entity that resembles carcinoma of bladder in many aspects. However, the management of this benign condition is entirely different. Case report: Herein we report a case of mullerianosis of urinary bladder with a brief review of literature to make the fellow urologist aware and more adept in dealing with this condition. Conclusion: An awareness of this rare entity is necessary for adequate treatment and to the spare the patient of the stigma of a malignant disease.

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Müllerianosis of the urinary bladder: a rare and problematic bladder tumour

Cited by 5 publications

References 28 publications

Clear cell carcinoma of Mullerian origin in the urinary bladder: A rare entity

Clear cell carcinoma of Mullerian origin in the urinary bladder: A rare entity

Concurrent müllerianosis of the urinary bladder and the umbilicus presenting with umbilical bleeding: a rare case report and review of the literature

Mullerianosis of Urinary Bladder: A Great Impersonator of Malignant Urinary Bladder Tumours

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