Mullerianosis of the urinary bladder: report of a case with suggested metaplastic origin

Kořen, Jan; Menšíková, Jana; Mukenšnábl, Petr; Zámečnı́k, Michal

doi:10.1007/s00428-006-0153-1

Cited by 42 publications

(35 citation statements)

References 5 publications

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“…a–d,i; Table ). The immunohistochemical endocervicosis results were consistent with those of previous reports (Table ). Most of the staining characteristics were similar between the endocervicosis and the adenocarcinoma.…”

Section: Pathological Findingssupporting

confidence: 92%

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Adenocarcinoma arising in urinary bladder endocervicosis

Nakaguro

Tsuzuki

Shimada

et al. 2016

Pathology International

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Endocervicosis is a rare benign condition characterized by the presence of endocervical-type mucinous glands. Urinary bladder endocervicosis forms an elevated lesion in the posterior wall of the urinary bladder and is sometimes misdiagnosed as a malignant tumor clinically and pathologically. Herein we describe the first case of adenocarcinoma arising in urinary bladder endocervicosis. The patient, a 58-year-old woman, presented with asymptomatic hematuria. Cystoscopy revealed a nodular mass measuring 4 cm in diameter in the posterior wall, and total cystectomy was performed. Histology revealed that the elevated lesion of the bladder wall was composed of haphazard proliferation of cystic glands lined by benign endocervical-type epithelium. An adenocarcinoma arose at the center of this endocervicosis. Mucin histochemistry revealed the presence of sulfomucin in both the endocervicosis and adenocarcinoma components. Immunohistochemically, the endocervicosis was positive for cytokeratin (CK) 7, AE1/ AE3, CAM5.2, HBME1, CA19-9, and estrogen receptor (ER), and negative for CK20, CDX2, progesterone receptor (PR), MUC5AC, and β-catenin. The adenocarcinoma showed similar immunohistochemical results, except for loss of ER expression and a slight increase in the ratio of Ki-67-positive cells. This case indicates that endocervicosis, known as a benign lesion, harbors the possibility of malignant transformation.

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Section: Pathological Findingssupporting

confidence: 92%

“…The pathogenesis of endocervicosis has been discussed, and two main origins have been proposed: an implantative origin and a metaplastic origin . The implantative origin was based on a high‐frequency pelvic surgical history.…”

Section: Discussionmentioning

confidence: 99%

Adenocarcinoma arising in urinary bladder endocervicosis

Nakaguro

Tsuzuki

Shimada

et al. 2016

Pathology International

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“…A report of Müllerianosis in continuity with glandular cystitis provides further evidence for this possibility. 3 The case reported here supports an implantative origin of the Müllerian cells. Although a history of bladder endometriosis was reported by the patient, no evidence of other Müllerian epithelium was seen within the lesion.…”

Section: Discussionsupporting

confidence: 74%

Endosalpingiosis of the Urinary Bladder: A Case of Probable Implantative Origin With Characterization of Benign Fallopian Tube Immunohistochemistry

et al. 2009

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Müllerianosis of the bladder is an infrequently described lesion consisting of multiple Müllerian-type tissues within the urinary bladder. Few previous cases of pure endosalpingiosis have been described. Here we present a 54-year-old post-menopausal female with a history of prior pelvic surgery with traumatic bladder injury, who was found to have a cystic lesion in the posterior wall of the bladder. Routine histology demonstrated cyst epithelium characteristic of endosalpingiosis. Three benign Fallopian tube specimens were obtained and stained with the relevant immunohistochemical markers for comparison. Results showed an identical immunohistochemical profile between the bladder cyst lining and the normal Fallopian tube controls. This case represents a rare instance of pure endosalpingiosis of the urinary bladder, with a likely implantative origin. This form of bladder Müllerianosis should therefore be considered within the differential diagnosis of cystic lesions of the bladder.

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“…[10][11][12] As for the other pathologic conditions including endometrial lesions, fewer than 20 cases of Müllerianosis of the bladder have been reported. [13][14][15] This rare entity is characterized by the presence of an admixture of at least 2 types of Müllerian tissue leading to endometriosis, endocervicosis, and endosalpingosis in the lamina propria and muscularis propria of the bladder. Müllerianosis can occur without any history of pelvic surgery and the histologic and immunohistochemical features support the idea of a metaplastic origin in embryonic duct remnants.…”

Section: Discussionmentioning

confidence: 99%

Scar Endometriosis in a Patient With Bladder Exstrophy

Kitajima

Inoue

Uchida

et al. 2013

International Surgery

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Endometriosis is an ectopic occurrence of tissue morphologically and functionally resembling endometrial tissue in regions outside the uterine cavity. Although scar endometriosis after surgery has been shown to be most common among all the extrapelvic forms of endometriosis, endometriosis after bladder exstrophy surgery has not been reported, and here we present the first known case. A 26-year-old woman with a history of bladder exstrophy was aware of a painful induration at the operative scar located in the left lower abdominal wall, and presented at our hospital. Although the symptoms resolved, recurring exacerbation was observed after 9 months. Abdominal magnetic resonance imaging showed a heterogeneous mass 16 mm in diameter in the left abdominal wall with high signal intensity on T1W1 and T2W1 images. She underwent excisional biopsy of the lesion under general anesthesia. Histopathology confirmed the diagnosis of endometriosis. Eighteen months after surgery, she was well and free from recurrence.

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Mullerianosis of the urinary bladder: report of a case with suggested metaplastic origin

Cited by 42 publications

References 5 publications

Adenocarcinoma arising in urinary bladder endocervicosis

Adenocarcinoma arising in urinary bladder endocervicosis

Endosalpingiosis of the Urinary Bladder: A Case of Probable Implantative Origin With Characterization of Benign Fallopian Tube Immunohistochemistry

Scar Endometriosis in a Patient With Bladder Exstrophy

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