Mullerian inhibiting substance, sex hormone binding globulin and sex hormone levels in stimulant-naïve, first-diagnosed prepubertal boys with attention-deficit/hyperactivity disorder: comparison with matched healthy controls as well as before and after oros-methylpenidate treatment

Gökçen, Cem; Erbağcı, Ahmet; Mutluer, Tuba; Örkmez, Mustafa; Correll, Christoph U.

doi:10.1080/13651501.2019.1602657

Cited by 4 publications

(1 citation statement)

References 36 publications

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“…An animal study has shown that the concentrations of progesterone were significantly elevated in 10-week-old hypertensive rats when compared to 10-week-old normotensive rats [24]. Compared to age-and sex-matched healthy control boys, prepubertal, stimulant-naïve boys with ADHD had significantly lower sex-hormone-binding globulin (SHBG) and higher free and bioavailable testosterone percentages [25]. One cross-sectional study revealed that free testosterone level did not have a significant correlation with ADHD clinical symptoms, but SHBG levels were found to be negatively correlated with ADHD behavior symptoms among boys [26].…”

Section: Introductionmentioning

confidence: 99%

Phthalates, Para-Hydroxybenzoic Acids, Bisphenol-A, and Gonadal Hormones’ Effects on Susceptibility to Attention-Deficit/Hyperactivity Disorder

Tsai

Chou

Lee

et al. 2020

Toxics

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This study aimed to examine whether endocrine-disrupting chemicals (EDCs), such as phthalates, para-hydroxybenzoic acids, and bisphenol-A (BPA), affect gonadal hormones and further link to the susceptibility to attention-deficit/hyperactivity disorder (ADHD). We recruited 98 boys with ADHD, 32 girls with ADHD, 42 boys without ADHD and any other psychiatric disorders, and 26 girls without ADHD and any other psychiatric disorders. Urine levels of EDCs, including mono-methyl phthalate (MMP), monoethyl phthalate (MEP), mono-n-butyl phthalate (MnBP), monobenzyl phthalate (MBzP), monoethylhexyl phthalate (MEHP), methylparaben (MP), ethylparaben (EP), propylparaben (PP), butylparaben (BP), and bisphenol A (BPA), were examined. Endocrine systems were evaluated by using the serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, free testosterone, estradiol, progesterone, sex hormone-binding globulin (SHBG), and prolactin. We found that boys with ADHD had higher levels of MnBP and EP than control boys. There were no significant differences regarding EDCs between the females with ADHD and control groups. No significant differences in testosterone, free testosterone, FSH, LH, estradiol, progesterone, or SHBG were found between the ADHD group and controls among either boys or girls. Among boys with ADHD, urine MBzP and MEHP levels were positively correlated with serum testosterone levels. Among girls, urine MEP levels were positively correlated with serum LH, testosterone, and free testosterone levels. The findings suggest that the possibility of an adverse impact of EDCs on gonadal hormones and neurodevelopment may exist. However, the results could be subject to potential selection bias, and the findings in this study should be interpreted with caution.

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Section: Introductionmentioning

confidence: 99%