Müllerian Adenosarcoma of the Cervix with Heterologous Elements: Report of a Case and Review of the Literature

Müllerian adenosarcoma of cervix in a young nulliparous woman

“…Recurrences may occur late. The role of chemotherapy and radiation is limited in the absence of extensive pelvic or residual disease [17]. Since the CT scan finding and intra-abdominal findings during surgery were suggestive of an extensive disease/involvement, which warranted radical surgery in our patient.…”

Mullerian adenosarcoma of the cervix: case report

“…6,24 Mean age of cases reported worldwide has been 33±18 years. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]24 Extensive literature review shows that the most common modes of clinical presentation are irregular menstrual bleeding (41%), painless mass in the introitus (41%), postmenstrual bleeding (7%), urinary retention (7%) and postcoital bleeding and vagina discharge (3% each). [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]24 Our patient presented with feeling of a mass in the introitus and irregular bleeding per vaginam.…”

“…The occurrence of heterologous differentiation, as seen in our case, has been about 69% and mostly as cartilage, bone and skeletal muscle. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Such heterologous elements, usually cartilaginous, as seen in this case, may also be seen in adenofibroma, carcinosarcoma and embryonal rhabdomyosarcoma (ERMS). Like ERMS MAs may show cambium-like disposition but phyllodes-like histology seen in MA is not present in ERMS.…”

“…Treatments given have included hysterectomy, with or without bilateral salpingo-oophorectomy, with or without pelvic lymph node clearance and with or without adjuvant chemo-and/ or radiotherapy. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] However, the underlying principle of management is to prevent recurrence and/or metastasis. In staging the disease it is our opinion that there may be need to carry out endometrial curettage, vaginal biopsy as well as exploratory laparotomy to exclude spread to other tissues because of their anatomical contiguity.…”

“…These tumours may affect any age group including children. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Mullerian adenosarcomas (MA) account for about 8% of all uterine sarcomas. 6 In Nigeria, even though Omoniyi-Esan et al 21 have reported 2 cases of pure sarcomas over a ten year period, our report, from available literature, is the first for MA in the country.…”