Müller cells and astrocytes in tractional macular disorders

Bringmann, Andreas; Unterlauft, Jan Darius; Barth, Thomas F.E.; Wiedemann, Renate; Rehák, Matúš; Wiedemann, Peter

doi:10.1016/j.preteyeres.2021.100977

Cited by 35 publications

(27 citation statements)

References 147 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, Müller cells might have a role as they transmit the traction forces from the inner to outer retina, leading to central photoreceptor layer defects and even neurosensorial retinal detachment. 13 …”

Section: Discussionmentioning

confidence: 99%

Asymptomatic Unilateral Full-Thickness Macular Hole in a Patient with Bietti Crystalline Dystrophy During 13-Year Follow-up with Optical Coherence Tomography

Saatçi

Kayabaşı

Avcı

2022

tjo

View full text Add to dashboard Cite

A 39-year-old woman with progressive bilateral visual decline was diagnosed as having Bietti crystalline dystrophy in 2008. The disease course was monitored with optical coherence tomography until 2021. During the last routine eye examination in 2021, a full-thickness, slightly eccentric, visually asymptomatic macular hole with an intact foveola was noted in the left eye. No surgical treatment was recommended. The pathogenesis of full-thickness macular hole remained unclear as there were only subtle signs of prior very mild macular edema and vitreomacular interface abnormality. A degenerative process was also possible.

show abstract

Section: Discussionmentioning

confidence: 99%

Asymptomatic Unilateral Full-Thickness Macular Hole in a Patient with Bietti Crystalline Dystrophy During 13-Year Follow-up with Optical Coherence Tomography

Saatçi

Kayabaşı

Avcı

2022

tjo

View full text Add to dashboard Cite

show abstract

“…Similarly, the hyperreflectivity of the Henle fiber bundles which surround the cystoid spaces in the HFL of eyes with high-grade foveal hypoplasia might be caused by an altered position of Henle fibers to the incident light. Gliosis of Müller cell processes, which surround the photoreceptor cell axons [ 34 ] and which is associated with cell process hypertrophy and upregulation of glial intermediate filaments [ 45 , 46 ] that both alter the optical properties of the cells, may contribute to the increased reflectivity of erected Henle fiber bundles.…”

Section: Discussionmentioning

confidence: 99%

“…The formation of cystoid spaces in the HFL may be supported by the histological feature of this layer. The HFL is a layer with a low mechanical cohesion because it is composed of Henle fibers which are not connected and which can be shifted or even erected, e.g., in eyes with anterior traction to the macula or due to intraretinal fluid accumulation resulting in foveoschisis or edematous cystoid spaces [ 46 – 48 ]. Erection of Henle fibers results in a thickening of the HFL and a large increase of the extracellular space volume within the HFL.…”

Section: Discussionmentioning

confidence: 99%

Morphology of foveal hypoplasia: Hyporeflective zones in the Henle fiber layer of eyes with high-grade foveal hypoplasia

2022

Self Cite

View full text Add to dashboard Cite

Background Foveal hypoplasia is characterized by the persistance of inner retinal layers at the macular center. We evaluated using spectral-domain optical coherence tomography (SD-OCT) morphological parameters of the macular center of eyes with foveal hypoplasia and describe the presence of hyporeflective zones in the Henle fiber layer (HFL) of eyes with high-grade foveal hypoplasia. Methods Eyes with foveal hypoplasia were classified into two groups: high-grade foveal hypoplasia with thick inner retinal layers at the macular center (thickness above 100 μm; 16 eyes of 9 subjects) and low-grade foveal hypoplasia with thinner inner retinal layers at the macular center (thickness below 100 μm; 25 eyes of 13 subjects). As comparison, SD-OCT images of normal control eyes (n = 75) were investigated. Results Eyes with foveal hypoplasia displayed shorter central photoreceptor outer segments (POS), a thinner central myoid zone, and a thicker central HFL compared to control eyes. Eyes with high-grade foveal hypoplasia also displayed a thinner central outer nuclear layer (ONL) compared to eyes with low-grade foveal hypoplasia and control eyes. There was a negative correlation between the thicknesses of the central ONL and HFL in eyes with foveal hypoplasia; however, the total thickness of both ONL and HFL was similar in all eye populations investigated. Visual acuity of subjects with foveal hypoplasia was negatively correlated to the thickness of the central inner retinal layers and positively correlated to the length of central POS. In contrast to central POS, the length of paracentral POS (0.5 and 1.0 mm nasal from the macular center) was not different between the three eye populations investigated. The paracentral ONL was thickest in eyes with high-grade foveal hypoplasia and thinnest in control eyes. Hyporeflective zones in the HFL were observed on SD-OCT images of eyes with high-grade foveal hypoplasia, but not of eyes with low-grade foveal hypoplasia and control eyes. OCT angiography images recorded at the level of the HFL of eyes with high-grade foveal hypoplasia showed concentric rings of different reflectivity around the macular center; such rings were not observed on images of eyes with low-grade foveal hypoplasia and control eyes. Conclusions It is suggested that the hyporeflective zones in the HFL of eyes with high-grade foveal hypoplasia represent cystoid spaces which are surrounded by Henle fiber bundles. Cystoid spaces are likely formed because there are fewer Henle fibers and a thinner central ONL despite an unchanged thickness of both ONL and HFL. Cystoid spaces may cause the concentric rings of different reflectivity around the macular center in the HFL of eyes with high-grade foveal hypoplasia.

show abstract

“…This is mediated by the outer processes of the Müller cells of the foveal walls and parafovea, which seal the outer fovea and thereby contribute to the regeneration of outer layers at the fovea. [ 18 ] Centripetal contraction of Muller cell processes also leads to central displacement of photoreceptor cell somata near and at ELM. [ 19 ]…”

Section: Discussionmentioning

confidence: 99%

Indistinct retinal outer layers in the walls of the idiopathic full-thickness macular hole - A potential predictive biomarker for surgical outcomes

Patel

Delhiwala

Khamar

2022

Indian Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose: To evaluate the absence of external limiting membrane (ELM) and ellipsoid zone (indistinct retinal outer layers, I-ROL) in the walls of idiopathic full-thickness macular holes (FTMHs) circumferentially on optical coherence tomography (OCT) and its correlation with surgical outcome. Methods: In this retrospective observational study, OCT images of patients undergoing vitrectomy for FTMHs with at least 3-months of postoperative follow-up were analyzed for preoperative circumferential extent of I-ROL. Derived macular hole indices such as hole form factor (HFF), macular hole index (MHI), tractional hole index (THI), and hole diameter ratio (HDR) were also calculated. The circumferential extent of I-ROL was correlated with derived hole indices as well as anatomical closure, foveal architecture, and restoration of ELM following surgery. Results: All nine eyes (eight patients) with FTMH (mean size: 610.11 ± 122.95 microns) in the study showed I-ROL in ≥1 quadrant. The mean HFF, MHI, THI, and HDR values were 0.72 ± 0.09, 0.35 ± 0.05, 0.71 ± 0.24, and 0.53 ± 0.14, respectively. All eyes achieved type-1 hole closure with improvement in best-corrected visual acuity to 0.58 ± 0.32 LogMAR from 0.81 ± 0.26 LogMAR. Regular foveal architecture was achieved in six eyes. Out of these, five eyes had I-ROL in ≥2 quadrants, and one eye had I-ROL in <2 quadrants ( P = 0.0476). Restoration of ELM was seen in aforementioned six eyes (complete = 5, partial = 1). Out of the five eyes with complete ELM restoration, four had a circumferential extent of I-ROL in ≥2 quadrants ( P = 0.0476). Complete restoration of ELM was associated with the complete restoration of the ellipsoid zone in three eyes. Conclusion: Preoperative circumferential extent of I-ROL in FTMH walls can be a potential predictive OCT marker for the type of closure, postoperative foveal architecture, and ELM restoration.

show abstract

Müller cells and astrocytes in tractional macular disorders

Cited by 35 publications

References 147 publications

Asymptomatic Unilateral Full-Thickness Macular Hole in a Patient with Bietti Crystalline Dystrophy During 13-Year Follow-up with Optical Coherence Tomography

Asymptomatic Unilateral Full-Thickness Macular Hole in a Patient with Bietti Crystalline Dystrophy During 13-Year Follow-up with Optical Coherence Tomography

Morphology of foveal hypoplasia: Hyporeflective zones in the Henle fiber layer of eyes with high-grade foveal hypoplasia

Indistinct retinal outer layers in the walls of the idiopathic full-thickness macular hole - A potential predictive biomarker for surgical outcomes

Contact Info

Product

Resources

About