Müller Cell Involvement in Methanol-Induced Retinal Toxicity

Garner, Charles D.; Lee, E W; Louis-Ferdinand, Robert T.

doi:10.1006/taap.1995.1014

Cited by 34 publications

(14 citation statements)

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“…CFF was also proven in this study to be influenced by alcohol abuse. This is in line with the findings of Kircheis et al 17 One possible explanation is that retinal changes in hepatic retinopathy are similar to changes caused by alcohol abuse as shown previously 27. In addition, alcohol abuse is accompanied by cortical dysfunction 28.…”

Section: Discussionsupporting

confidence: 90%

Comparison of the most favoured methods for the diagnosis of hepatic encephalopathy in liver transplantation candidates

Goldbecker

Weißenborn

Shahrezaei

et al. 2013

Gut

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Section: Discussionsupporting

confidence: 90%

Comparison of the most favoured methods for the diagnosis of hepatic encephalopathy in liver transplantation candidates

Goldbecker

Weißenborn

Shahrezaei

et al. 2013

Gut

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“…In addition to neurofunctional changes, bioenergetic and morphological alterations indicative of formate-induced disruption of retinal energy metabolism have been documented in experimental methanol intoxication (Murray et al, 1991;Eells et al, 1995;Gamer et al, 1995). Morphological studies, coupled with cytochrome oxidase histochemistry, revealed generalized retinal edema, photoreceptor and retinal pigment epithelium vacuolation, mitochondrial swelling, and a reduction in cytochrome oxidase activity in photoreceptor mitochondria from methanol-intoxicated rats (Murray et al, 1991;Eells et al, 1995Eells et al, , 1996b.…”

Section: Disruption Of Retinal Mitochondrial Function By Formate In Mmentioning

confidence: 99%

Mitochondria-Mediated Cell Injury

et al. 1997

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“…Histopathologic changes were apparent in photoreceptors and RPE cells, with evidence of inner segment swelling and mitochondrial disruption. 30,40,43,44 This study found no signifi cant changes in the ERG over time. MERG results corroborated this, indicating that even the isolation of retinal responses into regions did to establish the safety of calcium formate for the general population.…”

Section: Resultsmentioning

confidence: 79%

Ocular and Systemic Safety Evaluation of Calcium Formate as a Dietary Supplement

Altaweel

Hanzlik

Hoeve

et al. 2009

Journal of Ocular Pharmacology and Therapeutics

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Purpose: The objective of this study was to perform a preliminary evaluation of the ocular and systemic safety of calcium formate, a dietary calcium supplement for prevention and management of osteoporosis. Although formate is an endogenous product of metabolism, high concentrations are associated with toxicity during methanol overdose. Methods: In this prospective clinical trial, 12 healthy women ingested calcium formate (1,300 mg) three times a day for 14 days. Study evaluations included physical and ocular examination, extensive laboratory testing, serum calcium and formate levels, Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity, color vision, visual fi elds, visual evoked potential (VEP), and full-fi eld, pattern, and multifocal electroretinograms (MERG). Results: The mean baseline serum level of formate was 0.572 ± 0.06 mM. Peak serum levels and fi nal serum formate did not differ signifi cantly from baseline. The fi nal concentration was 0.582 ± 0.091 mM. Accumulation of serum formate did not occur. There was also no evidence of toxicity with calcium formate ingestion. All examinations and tests remained normal, including optic nerve and retinal function. Three subjects had mild transient symptoms attributable to any calcium formulation. Conclusions: Calcium formate is highly bioavailable and well-tolerated. Serum formate remained at basal levels and did not accumulate with repeated dosing. Systemic and ocular safety was demonstrated by objective testing. Given its high oral bioavailability, calcium formate may be a good choice for calcium supplementation in the prevention and management of osteoporosis. Further study will be needed to evaluate its long-term safety in a larger group of subjects representing more varied age, health, dietary, and nutritional status.

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Müller Cell Involvement in Methanol-Induced Retinal Toxicity

Cited by 34 publications

References 0 publications

Comparison of the most favoured methods for the diagnosis of hepatic encephalopathy in liver transplantation candidates

Comparison of the most favoured methods for the diagnosis of hepatic encephalopathy in liver transplantation candidates

Mitochondria-Mediated Cell Injury

Ocular and Systemic Safety Evaluation of Calcium Formate as a Dietary Supplement

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