Mulinane-type diterpenoids from Azorella compacta display antiplasmodial activity

Loyola, Luis A.; Bórquez, Jorge; Morales, Glauco; San-Martı́n, Aurelio; Dárias, José; Flores, Ninoska; Giménez, Alberto

doi:10.1016/j.phytochem.2004.06.011

Cited by 45 publications

(58 citation statements)

References 13 publications

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“…Azorellane diterpenoids have been demonstrated to have interesting biological activities such as antitubercular (Wachter et al, 1998), trichomonicidal (Loyola et al, 2001b), antiinflammatory (Delporte et al, 2003), contraceptive (Morales et al, 2003), anti-Trypanosoma cruzi (Araya et al, 2003), antiplasmodial (Loyola et al, 2004) and antihyperglycemic (Fuentes et al, 2005) effects. However, besides their high structural similarity to other anti-NF-κB sesquiterpenes lactones derived from the plant kingdom, the activity of these tetracyclic diterpenoids has never been investigated.…”

Section: Introductionmentioning

confidence: 99%

Azorellane diterpenoids from Laretia acaulis inhibit nuclear factor‐kappa B activity

Bórquez

Loyola

Morales

et al. 2007

Phytotherapy Research

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Transcription factor NF-kappaB plays a key role in the inducible expression of genes mediating proinflammatory effects, and is thus an important target for the development of antiinflammatory drugs. Laretia acaulis (Cav.) Gill et Hook (Apiaceae) is a medicinal plant used in the high Andes mountains for different ailments such as diabetes, inflammation and for general pain. In addition to the known azorellanol (2) and 7-deacetylazorellanol (4), 13-epiazorellanol (1) was also isolated from the aerial part of this plant. Its structure was based on spectroscopic comparison with azorellanol (2) and by chemical characterization. While compounds 2 and 4 showed potent anti-NF-kappaB activity by targeting the activity of the IkappaBalpha kinase, compound 1 was completely inactive highlighting the importance of position 13 in the biological activities of this class of tetracyclic diterpenoids.

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Section: Introductionmentioning

confidence: 99%

Azorellane diterpenoids from Laretia acaulis inhibit nuclear factor‐kappa B activity

Bórquez

Loyola

Morales

et al. 2007

Phytotherapy Research

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“…Another criterion for selection included species belonging to the family Asteraceae (E. buniifolium and B. spicata) with precedent of antiprotozoal activity (Chiari et al 1996) or species with potential bioactive antiprotozoal compounds such as mulinane-type diterpenoids, as is the case for M. spinosum (Araya et al 2003;Loyola et al 2004). …”

Section: Introductionmentioning

confidence: 99%

In vitro evaluation of trypanocidal activity in plants used in Argentine traditional medicine

et al. 2005

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Thirty-two organic and aqueous extracts, belonging to 12 Argentine medicinal plants were tested for their in vitro trypanocidal activity on epimastigote forms of Trypanosoma cruzi. Among the selected species, the organic extracts of Ambrosia scabra, Ambrosia tenuifolia, Baccharis spicata, Eupatorium buniifolium, Lippia integrifolia, Mulinum spinosum and Satureja parvifolia, and the aqueous extracts of E. buniifolium, L. integrifolia, M. spinosum and S. parvifolia showed trypanocidal activity with a percentage of growth inhibition higher than 70% at a concentration of 100 microg/ml.

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“…An interesting group of bioactive metabolites, such as triterpenoids and diterpenoids with azorellane and mulinane skeletons have been obtained from Azorella, and Mulinum genera (Borquez et al,2011;Chiaramello et al, 2003a;Colloca et al,2004;Molina-Salinas et al,2010;Morales et al, 2003;Areche et al, 2009). So, some authors demonstrated that these metabolites display a wide variety of biological activities, including antimycobacterial activity (Molina-Salinas et al, 2010), trichomonicidal activity (Loyola et al, 2001), trypanocidal activity (Araya et al, 2003) and antiplasmodial activity (Loyola et al, 2004). To our knowledge, there are few reports available in the literature on activity of organic extracts of M. echegarayii and Azorella trifurcata against pathogenic bacteria tested in this study.…”

Section: Resultsmentioning

confidence: 99%

Azorella trifurcata and Mulinum echegarayii obtained from central region of<br>Argentina: antibacterial activity of their organic extracts

Satorres

Chiaramello

Mattana

et al. 2013

Emir. J. Food Agric

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The natural products derived from medicinal plants have proven to be an abundant source of compounds with antibacterial activity. The antibacterial activity of extracts of Azorella trifurcata and M. echegarayii was evaluated against strains of Staphylococcus aureus ATCC 43300, Pseudomonas aeruginosa ATCC 27853, Listeria monocytogenes CLIP 74902 and Escherichia coli ATCC 35218. Organic extracts were prepared using n-hexane, mixtures of n-hexane and ethyl acetate of increasing polarity and a mixture of ethyl acetate and methanol on flash chromatography. All the extracts of A. trifurcata showed antibacterial effects against grampositive bacteria (CIM between 0.5 and 2 mg/ml). Four extracts (100% n-hexane, 40:60/50:50 acetate: nhexane, 70:30 ethyl acetate: n-hexane and 2:98 methanol: ethyl acetate) of A. trifurcata showed antibacterial activity against gram-negative bacteria. M. echegarayii 2:98 methanol: ethyl acetate was active against all gram-negative and gram-positive bacteria (CIM between 1 and 2 mg/ml). The values of MBC of the extracts assayed were one or two times higher than corresponding MIC values. The discovery of organics extracts with antibacterial properties could contribute to the treatment of bacterial infections.

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Mulinane-type diterpenoids from Azorella compacta display antiplasmodial activity

Cited by 45 publications

References 13 publications

Azorellane diterpenoids from Laretia acaulis inhibit nuclear factor‐kappa B activity

Azorellane diterpenoids from Laretia acaulis inhibit nuclear factor‐kappa B activity

In vitro evaluation of trypanocidal activity in plants used in Argentine traditional medicine

Azorella trifurcata and Mulinum echegarayii obtained from central region of<br>Argentina: antibacterial activity of their organic extracts

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