Mulberry Leaf and Neochlorogenic Acid Alleviates Glucolipotoxicity-Induced Oxidative Stress and Inhibits Proliferation/Migration via Downregulating Ras and FAK Signaling Pathway in Vascular Smooth Muscle Cell

Yang, Tsung‐Yuan; Wu, Yi-Liang; Yu, Meng-Hsun; Hung, Tung-Wei; Chan, Kuei-Chuan; Wang, Chau‐Jong

doi:10.3390/nu14153006

Cited by 7 publications

(7 citation statements)

References 37 publications

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“…Neochlorogenic acid is one of the effective components of QDT. Neochlorogenic acid inhibited migration and proliferation of vascular smooth muscle cells by inhibiting FAK/small GTPase protein, PI3K/Akt and ras related signals, thus playing an anti atherosclerosis role ( Yang et al, 2022 ). Lignans were the effective fraction of Duzhong for antihypertension.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of Qiangli Dingxuan tablet combined with amlodipine besylate for essential hypertension: a randomized, double-blind, placebo-controlled, parallel-group, multicenter trial

et al. 2023

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Background: Hypertension, a major cardiovascular risk factor, severely impacts patients’ quality of life. Qiangli Dingxuan tablet (QDT) is a formally approved Chinese patent medicine, which has been widely used as an adjunctive treatment for hypertension. This study aimed to investigate the antihypertensive efficacy and safety of QDT combined with amlodipine besylate in patients with essential hypertension.Methods: In this randomized, double-blind, placebo-controlled, parallel-group, multicenter trial conducted in China, patients diagnosed with grade 1 to 2 essential hypertension were randomly assigned in a 1:1 to the treatment of QDT or placebo for 12 weeks, alongside their ongoing treatment with amlodipine besylate. The primary outcome was the change in office blood pressure (BP) from baseline to 12 weeks. In addition, safety analysis included the assessment of vital signs and laboratory values.Results: At baseline, 269 patients were randomly assigned to the QDT group (n = 133) or the placebo group (n = 136), and there were no significant differences in baseline characteristics between the two groups. The primary outcome based on the full analysis set from baseline to 12 weeks showed that the mean difference in the change of office systolic BP reduction between the two groups was 6.86 mmHg (95%CI, 4.84 to 8.88, p < 0.0001), for office diastolic BP, the mean difference in the change of office diastolic BP reduction between the two groups was 4.64 mmHg (95%CI, 3.10 to 6.18, p < 0.0001). In addition, traditional Chinese medicine symptom scores were significantly decreased in the QDT group compared with the placebo group. No severe adverse events attributable to QDT were reported.Conclusion: The combination of QDT and amlodipine besylate demonstrates superior efficacy compared to amlodipine besylate monotherapy in the management of essential hypertension. QDT shows potential as an adjunctive treatment for essential hypertension. However, further rigorous clinical trials are warranted to validate these findings.Clinical Trial Registration: [https://clinicaltrials.gov/study/NCT05521282?cond=NCT05521282&rank=1]; Identifier: [NCT05521282]

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Section: Discussionmentioning

confidence: 99%

Efficacy and safety of Qiangli Dingxuan tablet combined with amlodipine besylate for essential hypertension: a randomized, double-blind, placebo-controlled, parallel-group, multicenter trial

et al. 2023

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“…In addition, mulberry leaves at 100, 200, and 400 mg/kg significantly and dose-dependently attenuated thrombus formation in the rat arteriovenous shunt model in vivo [12]. Mulberry leaves may also become a useful drug for the treatment of metabolic syndrome and its related atherosclerotic lesion formation [15]. Yang et al determined the consequence of mulberry leaf extract and its major component, neochlorogenic acid, on the proliferation and migration of rat aortic vascular smooth muscle cells (VSMCs, A7r5 cell line) under diabetic cultured conditions [15].…”

Section: White Mulberrymentioning

confidence: 99%

Health Benefits of White Mulberry, Sea–Buckthorn, Garlic, Lily of the Valley, Motherwort, and Hawthorn — Prevention and Treatment of Cardiovascular Disease

Witkowska,

Gryn–Rynko,

Syrkiewicz

et al. 2024

Preprint

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Cardiovascular diseases are a broadly understood concept focusing on vascular and heart dys-function. Lack of physical exercise, type 2 diabetes, obesity, hypertension, dyslipidemia, throm-boembolism, kidney, and lung diseases all contribute to the development of heart and blood vessel dysfunction. Although effective and important, traditional treatment with diuretics, statins, beta–blockers, calcium inhibitors, ACE inhibitors, and anti–platelet drugs remain a second–line treatment after dietary intervention and lifestyle changes. Scientists worldwide are still looking for an herbal product that would be quite effective and free from side effects, either taken together or before the standard pharmacological intervention. Such herbal–originated medication therapy may include Morus alba L. (white mulberry), Elaeagnus rhamnoides (L.) A. Nelson (sea–buckthorn), Allium sativum L. (garlic), Convallaria majalis L. (lily of the valley), Leonurus cardiaca L. (mother-wort), and Crataegus spp. (hawthorn). Valuable herbal raw materials include leaves, fruits, seeds, and even thorns. This short review focuses on six herbs that can constitute an interesting and po-tential therapeutic option in the management of cardiovascular disorders.

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“…Neochlorogenic acids (Ncg) make up a class of phenolic compounds found in mulberry leaves that have anti-inflammatory and antiaging properties. Ncgs can inhibit cellular inflammatory responses through the AMPK pathway and have a protective effect against lipopolysaccharide (LPS)-induced oxidative stress . Therefore, Ncg may be a potential drug for the treatment of disk degeneration.…”

Section: Introductionmentioning

confidence: 99%

“…Ncgs can inhibit cellular inflammatory responses through the AMPK pathway 14 and have a protective effect against lipopolysaccharide (LPS)-induced oxidative stress. 15 Therefore, Ncg may be a potential drug for the treatment of disk degeneration. Nrf2 is an important transcription factor involved in mediating cellular adaptive stimulation to oxidation.…”

Section: Introductionmentioning

confidence: 99%

Neochlorogenic Acid Combined with Bone Marrow Mesenchymal Stem Cells Encapsulated into GelMA Hydrogel for Transplantation to Repair Intervertebral Disk Degeneration

Fang,

Hu,

Zou

et al. 2024

Biomacromolecules

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Intervertebral disk degeneration is a common disease with an unknown etiology. Currently, tissue engineering is considered to be an important method for intervertebral disk repair. Although transplanted stem cells may disrupt the repair process because of apoptosis caused by the oxidative microenvironment. Herein, bone marrow mesenchymal stem cell (BMSC) and Neochlorogenic acid (Ncg) were encapsulated into a GelMA hydrogel as a carrier to protect transplanted stem cells. Ncg effectively inhibited the oxidative stress process and reduced the apoptosis rate. A 5% GelMA hydrogel had a large pore size and porosity that provided an enhanced survival space for cells. An in vivo assessment showed that treatment with GelMA + BMSC + Ncg produced greater repair of degenerated intervertebral disks than that found in other model groups. Thus, this study may help contribute to improving stem cell transplantation for treating intervertebral disk degeneration.

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Mulberry Leaf and Neochlorogenic Acid Alleviates Glucolipotoxicity-Induced Oxidative Stress and Inhibits Proliferation/Migration via Downregulating Ras and FAK Signaling Pathway in Vascular Smooth Muscle Cell

Cited by 7 publications

References 37 publications

Efficacy and safety of Qiangli Dingxuan tablet combined with amlodipine besylate for essential hypertension: a randomized, double-blind, placebo-controlled, parallel-group, multicenter trial

Efficacy and safety of Qiangli Dingxuan tablet combined with amlodipine besylate for essential hypertension: a randomized, double-blind, placebo-controlled, parallel-group, multicenter trial

Health Benefits of White Mulberry, Sea–Buckthorn, Garlic, Lily of the Valley, Motherwort, and Hawthorn — Prevention and Treatment of Cardiovascular Disease

Neochlorogenic Acid Combined with Bone Marrow Mesenchymal Stem Cells Encapsulated into GelMA Hydrogel for Transplantation to Repair Intervertebral Disk Degeneration

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