Muju Virus, Harbored by Myodes regulus in Korea,  Might Represent a Genetic Variant of Puumala Virus,  the Prototype Arvicolid Rodent-Borne Hantavirus

Lee, Jin Goo; Gu, Se Hun; Baek, Luck Ju; Shin, Ok Sarah; Park, Kwang Sook; Kim, Sang Hyun; Klein, Terry A.; Yanagihara, Richard; Song, Jin Won

doi:10.3390/v6041701

Cited by 13 publications

(14 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, geographic-specific genetic variants have been reported for Puumala virus in the bank vole (Myodes glareolus) (Garanina et al 2009), Tula virus in the European common vole (Microtus arvalis) (Song et al 2004), and Andes virus in the colilargo (Oligoryzomys longicaudus) (Torres-Perez et al 2011). Both Muju virus in the royal vole (Myodes regulus) (Lee et al 2014) and Hokkaido virus in the grey red-backed vole (Myodes rufocanus) and northern red-backed vole (Myodes rutilus) (Yashina et al 2015) may represent genotypes of Puumala virus. These examples point to the urgency of studying the phylogeographic variation of viruses and their hosts to provide an essential foundation for understanding their evolutionary histories and as a prelude to forecasting their future emergence under changing environmental conditions (Hope et al 2013, Campbell et al 2015.…”

Section: Resultsmentioning

confidence: 99%

Genetic Diversity of Artybash Virus in the Laxmann's Shrew (Sorex caecutiens)

Arai

Kang

et al. 2016

Vector-Borne and Zoonotic Diseases

Self Cite

View full text Add to dashboard Cite

Although based on very limited M and L segment sequences, Artybash virus (ARTV) was proposed previously as a unique hantavirus harbored by the Laxmann's shrew (Sorex caecutiens). To verify this conjecture, lung tissues from 68 Laxmann's shrews, captured during 2006 to 2014 in eastern Siberia, Russia, and Hokkaido, Japan, were analyzed for ARTV RNA using reverse transcription polymerase chain reaction (RT-PCR). ARTV RNA was detected in six Laxmann's shrews. Pairwise alignment and comparison of partial-and full-length S, M, and L segment sequences from these Laxmann's shrews, as well as phylogenetic analyses, using maximum likelihood and Bayesian methods indicated that ARTV was distinct from other soricine shrew-borne hantaviruses and representative hantaviruses harbored by rodents, moles, and bats. Taxonomic identity of the ARTVinfected Laxmann's shrews was confirmed by full-length cytochrome b mitochondrial DNA sequence analysis. Our data indicate that the hantavirus previously known as Amga virus (MGAV) represents genetic variants of ARTV. Thus, the previously proposed designation of ARTV/MGAV should be replaced by ARTV.

show abstract

Section: Resultsmentioning

confidence: 99%

Genetic Diversity of Artybash Virus in the Laxmann's Shrew (Sorex caecutiens)

Arai

Kang

et al. 2016

Vector-Borne and Zoonotic Diseases

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, the threat of hantaviruses is of major concern, as it has been detected in pet rats in the United Kingdom and in Sweden (McElhinney et al, 2016). Some recently discovered hantaviruses, such as the Muju virus (MUJV) detected in the royal vole (also known as the Korean red-backed vole; Myodes regulus), and the Imjin (MJNV) and Jeju viruses (JJUV) in the shrew and bat, have been reported in Korea (Lee et al, 2014). The hantavirus genome referred to as the Asama virus (ASAV) has been detected in the Japanese shrew mole (Urotrichus talpoides) (Arai et al, 2008).…”

Section: Nonpathogenic Hantaviruses and Their Reservoirsmentioning

confidence: 99%

Hantavirus infection: a global zoonotic challenge

et al. 2017

View full text Add to dashboard Cite

Hantaviruses are comprised of tri-segmented negative sense single-stranded RNA, and are members of the Bunyaviridae family. Hantaviruses are distributed worldwide and are important zoonotic pathogens that can have severe adverse effects in humans. They are naturally maintained in specific reservoir hosts without inducing symptomatic infection. In humans, however, hantaviruses often cause two acute febrile diseases, hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS). In this paper, we review the epidemiology and epizootiology of hantavirus infections worldwide.

show abstract

“…In the present study, genetic analysis of hantaviruses in M. rutilus, M. rufocanus and M. glareolus , sharing the same ecological habitats in the Western Siberia, indicates that both M. rutilus and M. rufocanus serve as reservoir hosts of HOKV. Based on whole genome sequence analysis of MUJV (Lee et al, 2014) and findings from this investigation, HOKV and MUJV appear to represent genetic variants, or genotypes, of PUUV, rather than distinct hantavirus species. We, therefore, tentatively propose that HOKV and MUJV be called the Hokkaido and Muju genotypes of PUUV.…”

Section: Introductionmentioning

confidence: 81%

“…Geographic-specific clustering within distinct genetic lineages has been recognized for arvicolid rodent-borne hantaviruses, such as PUUV (Plyusnin et al, 1995; Sironen et al, 2001), MUJV (Lee et al, 2014; Song et al, 2007) and TULV (Song et al, 2004; Tkachenko et al, 2015). Available data on PUUV support the hypothesis that the phylogeography of different lineages was formed by separate post-glacial migrations of M. glareolus (Asikainen et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…Subsequently, genetic evidence of a PUUV-like hantavirus, designated Hokkaido virus (HOKV), was demonstrated in M. rufocanus trapped in Hokkaido, Japan (Kariwa et al, 1995, 1999; Sanada et al, 2012), the Far East region and Buryatia Republic of Russia (Plyusnina et al, 2008; Yashina et al, 2004, 2013) and Jilin province, China (Zhang et al, 2007). Another PUUV-like virus, named Muju virus (MUJV), was detected in M. regulus , trapped at multiple sites in the Republic of Korea (Lee et al, 2014; Song et al, 2007). Both HOKV and MUJV share a common ancestry with PUUV.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hokkaido genotype of Puumala virus in the grey red-backed vole ( Myodes rufocanus ) and northern red-backed vole ( Myodes rutilus ) in Siberia

Yashina

Abramov

Дупал

et al. 2015

Infection, Genetics and Evolution

Self Cite

View full text Add to dashboard Cite

Three species of Myodes voles known to harbor hantaviruses include the bank vole (Myodes glareolus), which serves as the reservoir host of Puumala virus (PUUV), the prototype arvicolid rodent-borne hantavirus causing hemorrhagic fever with renal syndrome (HFRS) in Europe, and the grey red-backed vole (M. rufocanus) and royal vole (M. regulus) which carry two PUUV-like hantaviruses, designated Hokkaido virus (HOKV) and Muju virus (MUJV), respectively. To ascertain the hantavirus harbored by the northern red-backed vole (M. rutilus), we initially screened sera from 233 M. rutilus, as well as from 90 M. rufocanus and 110 M. glareolus, captured in Western and Eastern Siberia during June 2007 to October 2009, for anti-hantaviral antibodies. Thereafter, lung tissues from 44 seropositive voles were analyzed for hantavirus RNA by reverse transcription-polymerase chain reaction. Partial L-, M- and S-segment sequences, detected in M. rutilus and M. rufocanus, were closely related to HOKV, differing from previously published L-, M- and S-segment sequences of HOKV by 17.8–20.2%, 15.9–23.4% and 15.0–17.0% at the nucleotide level and 2.6–7.9%, 1.3–6.3% and 1.2–4.0% at the amino acid level, respectively. Alignment and comparison of hantavirus sequences from M. glareolus trapped in Tiumen Oblast showed very high sequence similarity to the Omsk lineage of PUUV. Phylogenetic analysis, using neighbor-joining, maximal likelihood and Bayesian methods, showed that HOKV strains shared a common ancestry with PUUV and exhibited geographic-specific clustering. This report provides the first molecular evidence that both M. rutilus and M. rufocanus harbor HOKV, which might represent a genetic variant of PUUV.

show abstract

Muju Virus, Harbored by Myodes regulus in Korea, Might Represent a Genetic Variant of Puumala Virus, the Prototype Arvicolid Rodent-Borne Hantavirus

Cited by 13 publications

References 43 publications

Genetic Diversity of Artybash Virus in the Laxmann's Shrew (Sorex caecutiens)

Genetic Diversity of Artybash Virus in the Laxmann's Shrew (Sorex caecutiens)

Hantavirus infection: a global zoonotic challenge

Hokkaido genotype of Puumala virus in the grey red-backed vole ( Myodes rufocanus ) and northern red-backed vole ( Myodes rutilus ) in Siberia

Contact Info

Product

Resources

About