Abstract:pleckstrin homology (PH) domains are an important class of membrane targeting domains that specifically bind target phosphoinositides present at the surface of inner cell membranes. Aside from target lipid headgrouprecognition, the other protein-lipid interactions that occurduring membrane docking are not well defined. Currently, high-resolution structural characterization of protein-membrane interfaces is difficult to achieve while this information is crucial to a physical chemical understanding of reversible… Show more
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