Mucus-penetrating PEGylated polysuccinimide-based nanocarrier for intravaginal delivery of siRNA battling sexually transmitted infections

Currie, Sarah; Kim, Seungil; Gu, Xiaochen; Ren, Xiaoou; Lin, Francis; Liu, Shangxi; Yang, Chengbo; Kim, Ji‐Heung; Liu, Song

doi:10.1016/j.colsurfb.2020.111287

Cited by 12 publications

(2 citation statements)

References 48 publications

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“…[ 14 ] The data confirmed that DMG‐PEG concentration in LNPs is positively related to their mucus penetration ability and shear resistance, suggesting that PEGylation is an attractive design concept in mucus‐penetrated drug delivery carrier development. Even though many other researchers have also reported similar effects of PEGylation in particle mucus crossing, [ 141 ] there are also different sounds. Conte et al.…”

Section: Advanced Delivery Strategies To Improve the Pulmonary Bioava...mentioning

confidence: 95%

Recent Progress in Nucleic Acid Pulmonary Delivery toward Overcoming Physiological Barriers and Improving Transfection Efficiency

Wang,

Bu,

Dai

et al. 2024

Advanced Science

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Pulmonary delivery of therapeutic agents has been considered the desirable administration route for local lung disease treatment. As the latest generation of therapeutic agents, nucleic acid has been gradually developed as gene therapy for local diseases such as asthma, chronic obstructive pulmonary diseases, and lung fibrosis. The features of nucleic acid, specific physiological structure, and pathophysiological barriers of the respiratory tract have strongly affected the delivery efficiency and pulmonary bioavailability of nucleic acid, directly related to the treatment outcomes. The development of pharmaceutics and material science provides the potential for highly effective pulmonary medicine delivery. In this review, the key factors and barriers are first introduced that affect the pulmonary delivery and bioavailability of nucleic acids. The advanced inhaled materials for nucleic acid delivery are further summarized. The recent progress of platform designs for improving the pulmonary delivery efficiency of nucleic acids and their therapeutic outcomes have been systematically analyzed, with the application and the perspectives of advanced vectors for pulmonary gene delivery.

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Section: Advanced Delivery Strategies To Improve the Pulmonary Bioava...mentioning

confidence: 95%

Recent Progress in Nucleic Acid Pulmonary Delivery toward Overcoming Physiological Barriers and Improving Transfection Efficiency

Wang,

Bu,

Dai

et al. 2024

Advanced Science

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“…Polysuccinimide (PSI) is a non-toxic aspartic acid (ASP) polycondensation product [27]. PSI is biodegradable and pH responsive [28].…”

Section: Introductionmentioning

confidence: 99%

Development of Efficient Sodium Alginate/Polysuccinimide-Based Hydrogels as Biodegradable Acetaminophen Delivery Systems

Trinh,

Lim,

Lee

et al. 2023

Gels

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Efficient drug delivery systems are essential for improving patient outcomes. Acetaminophen (AP), which is a kind of oral administration, is a commonly used pain reliever and fever reducer. However, oral administration carries various health risks, especially overdose and frequent use; for instance, AP is administered approximately 4 times per day. Therefore, the aim of this study is to develop an efficient delivery system for once-daily administration by combining sodium alginate and polysuccinimide (PSI) hydrogels to delay the release of analgesic AP. PSI is a biodegradable polymer that can be used safely and effectively in drug delivery systems because it is eliminated by hydrolysis in the intestine. The use of PSI also improves the mechanical properties of hydrogels and prolongs drug release. In this study, hydrogel characterizations such as mechanical properties, drug dissolution ability, and biodegradability were measured to evaluate the hydrolysis of PSI in the intestine. Based on the results, hydrogels could be designed to improve the structural mechanical properties and to allow the drug to be completely dissolved, and eliminated from the body through PSI hydrolysis in the intestines. In addition, the release profiles of AP in the hydrogels were evaluated, and the hydrogels provided continuous release of AP for 24 h. Our research suggests that sodium alginate/PSI hydrogels can potentially serve as biodegradable delivery systems for AP. These findings may have significant implications for developing efficient drug delivery systems for other classes of drugs.

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PEGylated Nanoparticles as a Versatile Drug Delivery System

Mohapatra

Singh

Sahoo

2021

Nanoengineering of Biomaterials

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Mucus-penetrating PEGylated polysuccinimide-based nanocarrier for intravaginal delivery of siRNA battling sexually transmitted infections

Cited by 12 publications

References 48 publications

Recent Progress in Nucleic Acid Pulmonary Delivery toward Overcoming Physiological Barriers and Improving Transfection Efficiency

Recent Progress in Nucleic Acid Pulmonary Delivery toward Overcoming Physiological Barriers and Improving Transfection Efficiency

Development of Efficient Sodium Alginate/Polysuccinimide-Based Hydrogels as Biodegradable Acetaminophen Delivery Systems

PEGylated Nanoparticles as a Versatile Drug Delivery System

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