Mucus-Inspired Supramolecular Adhesives with Oil-Regulated Molecular Configurations and Long-Lasting Antibacterial Properties

Abstract

Inspired by mucus, which provides an ideal supramolecular model and whose fluid-like (viscous) and solid-like (elastic) behaviors can be adjusted to meet different physiological requirements, we report oil-regulated supramolecular adhesives by the co-assembly of polyurea oligomers and carvacrol oils. The adhesive is crosslinked by weak but abundant hydrogen bonds, which can be regulated by the incorporated carvacrol oils through the competition of intermolecular hydrogen bonds, presenting a unique set of mucus-mimicking features including oil-regulated mechanics, processability, reusable adhesivity, and extreme longevity in both air and water. Owing to the intrinsic bactericidal effect of the carvacrol oils, the developed adhesives can serve as potent antibacterial coatings with both rapid contact killing (99.9% killing within 15 min) and long-term controlled release abilities (up to 70 days), enabling versatile antibacterial applications in diverse conditions. We envision that these adhesives will be useful in buildings and architectures, community and public facilities, food storage and packaging technologies, functional textiles, and practical biomedical fields.

Zn‐MOF Encapsulated Antibacterial and Degradable Microneedles Array for Promoting Wound Healing

“…These drawbacks have seriously restricted the development of MNs in the field of promoting wound healing. [12][13][14][15][16][17] Thus, new-type MNs arrays with diverse compositions and expected functions are still anticipated in clinical practice. [18][19][20][21][22] In this paper, we propose a novel Zn-MOF encapsulated MNs array with features of anti-bacterial activity and degradability for promoting wound healing, as schemed in Figure 1.…”

“…These drawbacks have seriously restricted the development of MNs in the field of promoting wound healing. [ 12–17 ] Thus, new‐type MNs arrays with diverse compositions and expected functions are still anticipated in clinical practice. [ 18–22 ]…”

Bioinspired Supramolecular Slippery Organogels for Controlling Pathogen Spread by Respiratory Droplets

“…The main reason was that the carvacrol served as a hydrogen‐bond competitor, contributing to the dissociation of the hydrogen bonds between the HP chains. [ 37 ] Meanwhile, the carvacrol also endowed the organogels with bactericidal activity, as demonstrated in the disk diffusion assay of Staphylococcus aureus and Escherichia coli (Figure 1d and Figure S4, Supporting Information). With a compromise of mechanical strength and bactericidal property, the carvacrol ratio was chosen with 5 wt%, and the resultant organogel S 100 C 5 could harvest desirable mechanical strength, damage‐healing, slipperiness, and bactericidal properties.…”

Cheerios Effect Inspired Microbubbles as Suspended and Adhered Oral Delivery Systems

“…[ 1–4 ] Insights regarding how to simplify the administration methods and enhance the bioavailability of drugs have been gained to reduce the frequency of administration, and thus relieving chronic disease patients from tedious operation and mental pressure. [ 5–10 ] To reach these goals, a host of approaches have been developed, such as invasive treatment, oral administration, transdermal administration, etc. [ 11–15 ] Among them, oral administration is strongly preferred because it does not require a professional skill that allows patients to self‐administer drugs conveniently without dependence on the doctor.…”