Mucus and bicarbonate secretion in the stomach and their possible role in mucosal protection.

Allen, Adrian; Garner, A.

doi:10.1136/gut.21.3.249

Cited by 342 publications

(85 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Indeed, topical administration of 16,16-dimethyl PGE2 to resting canine gastric mucosa does cause vasodilatation (Cheung, 1980). Another possibility is that PGE2 averts mucosal damage through the stimulation of mucus and/or bicarbonate secretion (Allen & Garner, 1980). Topical application of PGE2 to the rat gastric mucosa does stimulate mucus production (Bolton, Palmer & Cohen, 1978), but as discussed above, there was no evidence in the present study that topical PGE2 caused luminal alkalinization.…”

Section: Discussioncontrasting

confidence: 53%

RELATIONSHIP BETWEEN LESION FORMATION AND PERMEABILITY OF RAT GASTRIC MUCOSA TO H⁺ AND OTHER CATIONS

Bunce

McCarthy

Spraggs

et al. 1982

British J Pharmacology

View full text Add to dashboard Cite

1 The relationship between lesion formation and ionic permeability has been investigated in rat gastric mucosa in vivo. Changes in these parameters were measured in the mucosa treated topically with prostaglandins E2 and A2 and/or aspirin. Particular attention was paid to the net flux of H+ ions across the gastric mucosa. 2 The effect of aspirin concentrations of 5 mM, 20 mm and '40 mm' (the latter, a suspension in a saturated solution) was investigated. Aspirin concentrations of 20 mM and '40 mm' produced a marked increase in lesion formation and increased the net mucosal to serosal flux of H+ ions. Aspirin 5 mm produced a significant increase in lesion formation but did not cause a significant change in net H+ ion flux. This result suggests that aspirin can have a direct irritant effect on the gastric mucosa and that the back diffusion of H+ ions is not a pre-requisite for the development of overt mucosal ulceration. 3 The effect of topically applied prostaglandin E2 (PGE2) on aspirin-induced gastric mucosal damage was investigated. Concentrations of PGE2 of 105 M and 10 4M ameliorated aspirininduced damage, but these changes were not necessarily accompanied by a significant reduction in net H+ ion flux. Again, this result is not consistent with a direct relationship between lesion formation and mucosal permeability to H+ ions. 4 Since PGA2 did not ameliorate aspirin-induced mucosal damage, the protective effect of PGE2 could not be attributed to its conversion to PGA2 in the acidic environment of the gastric lumen.5 Changes in gastric mucosal potential difference (p.d.) and net fluxes of Na+ and K+ ions may occur without a concomitant change in the permeability of the gastric mucosa to acid back-diffusion. Thus, the assumption cannot be made that a change in the permeability of the gastric mucosa to one particular ion reflects a general increase in ionic permeability.

show abstract

Section: Discussioncontrasting

confidence: 53%

RELATIONSHIP BETWEEN LESION FORMATION AND PERMEABILITY OF RAT GASTRIC MUCOSA TO H⁺ AND OTHER CATIONS

Bunce

McCarthy

Spraggs

et al. 1982

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…Furthermore, the subcellular localization was essentially identical among the epithelial and glandular cells: the major site of localization was the basolateral or lateral membrane characterized by an aggregation of microvilli. Although physiological studies have demonstrated that the oxyntic, antral, and duodenal mucosae are capable of secreting HC03-under basal and stimulated conditions for cytoprotection against luminal gastric acid ( ALLEN and GARNER, 1980;KONTUREK et al, 1983), we failed to detect an intense immunoreactivity with OS-3 in the oxyntic mucosa of rats. The present immunohistochemical findings suggest that these HC03-secretory cells, except those in the oxyntic mucosa, have a common mechanism of HC03 production/secretion and that OS-3 recognizes a functional molecule involved in that mechanism.…”

Section: Substance Recognized By Os-3mentioning

confidence: 44%

Immunohistochemical Identification of Type B Intercalated Cells in the Rat Kidney by a Monoclonal Antibody.

Yanase

Orikasa

Shimizu

et al. 1998

Archives of Histology and Cytology

View full text Add to dashboard Cite

“…In addition, the ability of anise suspension to protect gastric mucosa against lesions induced by chemical irritants is likely by maintaining the structural integrity of gastric epithelium and balance of aggressive factors and inherent protective mechanisms [52] . Further more, the mucus gel and its bicarbonate gradient seem to be an important first-line defense against harmful stimuli [53] .In conclusion, anise suspension exhibits an anti-ulcer potential activity through at least one or more possible mechanisms including inhibition of basal gastric secretion, stimulation of mucus secretion, endogenous gastric mucosal prostaglandin synthesis and possible antioxidative activity. …”

mentioning

confidence: 99%

Aqueous suspension of anise “Pimpinella anisum” protects rats against chemically induced gastric ulcers

Mofleh

Alhaider²,

Mossa³

et al. 2007

WJG

View full text Add to dashboard Cite

INTRODUCTIONPeptic ulcer is one of the most common gastrointestinal diseases. Nowadays proton pump inhibitors and H2-recptor antagonists are the most widely used drugs to treat peptic ulcer disease. However, the use of these antisecretory drugs may be associated with adverse events and ulcer relapse [1] . Thus, there is a need for more effective, less toxic and cost-effective anti-ulcer agents. In recent years, a widespread search has been launched to identify new anti-ulcer drugs from natural sources. Spices comprising the most important products used for flavouring foods and medicinal herbs are considered nowadays as potential bioactive agents that can interfere positively or negatively with different cellular processes. They are extensively used in medicine, pharmaceuticals, perfumery and cosmetics. Additionally they possess antioxidant, antispasmodic, carminative, anti-inflammatory and other properties [2] . A number of spices, namely large cardamom [3] , black pepper [4] , caraway [5] , cardamom [6] , clove [7] , coriander [8] , ginger [9] , peppermint [10] , saffron [11] , turmeric [12] among others have been shown to possess significant gastroprotective activities. The fruits of anise plant, pimpinella anisum L. are locally known as aniseed and yansoon. The powder and concoction of anise in hot water are used as carminatives, antiseptics, diuretics, digestives, aphrodisiacs, and as a remedy for insomnia and constipation [13] . Furthermore, anise is used to promote digestion, improve appetite, alleviate cramps and nausea, and relieve flatulence and colic. In Unani and Arabian traditional medicine, anise fruit and its oil have been used for the treatment of various conditions including dyspepsia, nausea, abdominal colic, RAPID COMMUNICATIONAqueous suspension of anise "Pimpinella anisum " protects rats against chemically induced gastric ulcers Ibrahim Abstract AIM:To substantiate the claims of Unani and Arabian traditional medicine practitioners on the gastroprotective potential effect of a popular spice anise, "Pimpinella anisum L." on experimentally-induced gastric ulceration and secretion in rats. METHODS:Acute gastric ulceration in rats was produced by various noxious chemicals including 80% ethanol, 0.2 mol/L NaOH, 25% NaCl and indomethacin. Anti-secretory studies were undertaken using pylorusligated Shay rat technique. Levels of gastric non-protein sulfhydryls (NP-SH) and wall mucus were estimated and gastric tissue was also examined histologically. Anise aqueous suspension was used in two doses (250 and 500 mg/kg body weight) in all experiments. RESULTS:Anise significantly inhibited gastric mucosal damage induced by necrotizing agents and indomethacin. The anti-ulcer effect was further confirmed histologically. In pylorus-ligated Shay rats, anise suspension significantly reduced the basal gastric acid secretion, acidity and completely inhibited the rumenal ulceration. On the other hand, the suspension significantly replenished ethanol-induced depleted levels of gastric mucosal NP-SH a...

show abstract

Mucus and bicarbonate secretion in the stomach and their possible role in mucosal protection.

Cited by 342 publications

References 54 publications

RELATIONSHIP BETWEEN LESION FORMATION AND PERMEABILITY OF RAT GASTRIC MUCOSA TO H⁺ AND OTHER CATIONS

RELATIONSHIP BETWEEN LESION FORMATION AND PERMEABILITY OF RAT GASTRIC MUCOSA TO H⁺ AND OTHER CATIONS

Immunohistochemical Identification of Type B Intercalated Cells in the Rat Kidney by a Monoclonal Antibody.

Aqueous suspension of anise “Pimpinella anisum” protects rats against chemically induced gastric ulcers

Contact Info

Product

Resources

About

Mucus and bicarbonate secretion in the stomach and their possible role in mucosal protection.

Cited by 342 publications

References 54 publications

RELATIONSHIP BETWEEN LESION FORMATION AND PERMEABILITY OF RAT GASTRIC MUCOSA TO H+ AND OTHER CATIONS

RELATIONSHIP BETWEEN LESION FORMATION AND PERMEABILITY OF RAT GASTRIC MUCOSA TO H+ AND OTHER CATIONS

Immunohistochemical Identification of Type B Intercalated Cells in the Rat Kidney by a Monoclonal Antibody.

Aqueous suspension of anise “Pimpinella anisum” protects rats against chemically induced gastric ulcers

Contact Info

Product

Resources

About

RELATIONSHIP BETWEEN LESION FORMATION AND PERMEABILITY OF RAT GASTRIC MUCOSA TO H⁺ AND OTHER CATIONS

RELATIONSHIP BETWEEN LESION FORMATION AND PERMEABILITY OF RAT GASTRIC MUCOSA TO H⁺ AND OTHER CATIONS