Mucus

McShane, Abigail; Bath, Jade R.; Jaramillo, Ana M.; Ridley, Caroline; Walsh, Agnes A; Evans, Christopher M.; Thornton, David J.; Ribbeck, Katharina

doi:10.1016/j.cub.2021.06.093

Cited by 69 publications

(46 citation statements)

References 15 publications

(2 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The other major constituent of pulmonary fluids is mucus, as vital for lubricating the airways as surfactant, and also for entrapment and cilliary clearance of inhaled particles and microbes 97 . Additionally, mucus can be important for control of bacterial infection, regulation of hydration, resolution of inflammation, and modulation of immune and epithelial cell function 98 , 99 .…”

Section: Environmental Imprinting Of Lung Macrophagesmentioning

confidence: 99%

“…Additionally, mucus can be important for control of bacterial infection, regulation of hydration, resolution of inflammation, and modulation of immune and epithelial cell function 98 , 99 . The main mucins expressed in the lung are Muc5b and Muc5ac, with Muc5b being essential for maintenance of healthy airways 97 , 99 , while Muc5ac is up-regulated during inflammation 100 – 102 . Each of these mucins has different properties that determine their dominant function.…”

Section: Environmental Imprinting Of Lung Macrophagesmentioning

confidence: 99%

“…Each of these mucins has different properties that determine their dominant function. Mucus also provides a home for commensal lung microbes 97 , which can exert a dramatic effect over airway function, for example through invasion/colonisation, consumption of nutrients, and production of metabolites – all of which can influence pulmonary inflammation and macrophage activation and function. Although most is currently known about bacteria and their products in this context, more widespread metagenomic approaches will increase our understanding of the abundance and diversity of bacterial, viral and fungal commensals in the lung, and how this changes during inflammation and disease.…”

Section: Environmental Imprinting Of Lung Macrophagesmentioning

confidence: 99%

See 2 more Smart Citations

The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity

2022

View full text Add to dashboard Cite

The last decade has been somewhat of a renaissance period for the field of macrophage biology. This renewed interest, combined with the advent of new technologies and development of novel model systems to assess different facets of macrophage biology, has led to major advances in our understanding of the diverse roles macrophages play in health, inflammation, infection and repair, and the dominance of tissue environments in influencing all of these areas. Here, we discuss recent developments in our understanding of lung macrophage heterogeneity, ontogeny, metabolism and function in the context of health and disease, and highlight core conceptual advances and key unanswered questions that we believe should be focus of work in the coming years.

show abstract

Section: Environmental Imprinting Of Lung Macrophagesmentioning

confidence: 99%

Section: Environmental Imprinting Of Lung Macrophagesmentioning

confidence: 99%

Section: Environmental Imprinting Of Lung Macrophagesmentioning

confidence: 99%

See 1 more Smart Citation

The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity

2022

View full text Add to dashboard Cite

show abstract

“…We previously evaluated the effect of the mucosal layer on drug permeation in the rat small intestine using DTT, resulting in the involvement of acidic mucins, such as Muc5ac, in the limitation of intestinal lipophilic drug absorption [15]. Mucins are the main structural protein components of the mucosal layer [17][18][19], composing gel-like networks with viscoelastic properties and acting as dynamic barriers to limit intestinal lipophilic drug absorption [20,21]. DTT can remove mucus from the epithelium by breaking disulfide bonds, which compose the basic structure of mucus [15], whereas SNP is known to interact with sulfhydryl (SH) groups of certain proteins to produce NO [12].…”

Section: Discussionmentioning

confidence: 99%

Utilization of Sodium Nitroprusside as an Intestinal Permeation Enhancer for Lipophilic Drug Absorption Improvement in the Rat Proximal Intestine

et al. 2021

View full text Add to dashboard Cite

As advanced synthetic technology has enabled drug candidate development with complex structure, resulting in low solubility and membrane permeability, the strategies to improve poorly absorbed drug bioavailability have attracted the attention of pharmaceutical companies. It has been demonstrated that nitric oxide (NO), a vital signaling molecule that plays an important role in various physiological systems, affects intestinal drug absorption. However, NO and its oxidants are directly toxic to the gastrointestinal tract, thereby limiting their potential clinical application as absorption enhancers. In this study, we show that sodium nitroprusside (SNP), an FDA-approved vasodilator, enhances the intestinal absorption of lipophilic drugs in the proximal parts of the small intestine in rats. The SNP pretreatment of the rat gastrointestinal sacs significantly increased griseofulvin and flurbiprofen permeation in the duodenum and jejunum but not in the ileum and colon. These SNP-related enhancement effects were attenuated by the co-pretreatment with dithiothreitol or c-PTIO, an NO scavenger. The permeation-enhancing effects were not observed in the case of antipyrine, theophylline, and propranolol in the duodenum and jejunum. Furthermore, the SNP treatment significantly increased acidic glycoprotein release from the mucosal layers specifically in the duodenum and jejunum but not in the ileum and colon. These results suggest that SNP increases lipophilic drug membrane permeability specifically in the proximal region of the small intestine through disruption of the mucosal layer.

show abstract

“…The human nasal cavity is nutritionally poor. However, mucosal cells display and secrete several high-molecular-weight glycosylated proteins such as sialylated glycans, or glycosylated proteins such as mucins [43][44][45][46]. These serve as nutrient sources for microbial communities via the secretion of degradative enzymes.…”

Section: Host Cells As a Source Of Nutrientsmentioning

confidence: 99%

Nutritional Interactions between Bacterial Species Colonising the Human Nasal Cavity: Current Knowledge and Future Prospects

Adolf

Heilbronner

2022

Metabolites

View full text Add to dashboard Cite

The human nasal microbiome can be a reservoir for several pathogens, including Staphylococcus aureus. However, certain harmless nasal commensals can interfere with pathogen colonisation, an ability that could be exploited to prevent infection. Although attractive as a prophylactic strategy, manipulation of nasal microbiomes to prevent pathogen colonisation requires a better understanding of the molecular mechanisms of interaction that occur between nasal commensals as well as between commensals and pathogens. Our knowledge concerning the mechanisms of pathogen exclusion and how stable community structures are established is patchy and incomplete. Nutrients are scarce in nasal cavities, which makes competitive or mutualistic traits in nutrient acquisition very likely. In this review, we focus on nutritional interactions that have been shown to or might occur between nasal microbiome members. We summarise concepts of nutrient release from complex host molecules and host cells as well as of intracommunity exchange of energy-rich fermentation products and siderophores. Finally, we discuss the potential of genome-based metabolic models to predict complex nutritional interactions between members of the nasal microbiome.

show abstract

Mucus

Cited by 69 publications

References 15 publications

The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity

The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity

Utilization of Sodium Nitroprusside as an Intestinal Permeation Enhancer for Lipophilic Drug Absorption Improvement in the Rat Proximal Intestine

Nutritional Interactions between Bacterial Species Colonising the Human Nasal Cavity: Current Knowledge and Future Prospects

Contact Info

Product

Resources

About