Mucous membrane plasmacytosis: A case report and review of the literature

Bharti, Rakesh; Smith, Dave

doi:10.5070/d30bn022pz

Cited by 42 publications

(18 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Polyclonal plasma cell infiltration with mixed population of kappa and lambda light chains and various heavy chains are seen in immune-peroxidase staining. 4,8 In this study, focal ulceration of lining stratified squamous epithelium with ulcer bed formed by acute on chronic inflammatory granulation tissue was seen. There was predominance of plasma cells with admixed neutrophils and lymphocytes.…”

Section: Discussionsupporting

confidence: 49%

Plasma cell mucositis masquerading as squamous cell carcinoma- a surgical dilemma: a rare case report and review of literature

Gopal

Singh

et al. 2022

Int J Otorhinolaryngol Head Neck Surg

View full text Add to dashboard Cite

<p>Plasma cell mucositis is a rare, idiopathic, multifocal, benign proliferative disorder affecting upper aerodigestive tract. It is a very rare condition and less than 50 cases reported in literature. A 62 years old female patient reported with complaints of oral discomfort, superficial erosive ulceration on the tongue, and burning sensation on eating food for last 2 years. Initially, Incisional biopsy of the involved mucosal area confirmed the diagnosis of well differentiated squamous cell carcinoma for which hemi-glossectomy was done. However histopathological examination submitted revealed a hyperplastic epithelium with a dense infiltrate of mature polyclonal plasma cells in the superficial layer of lamina propria, for which plasma cell mucositis was made a diagnosis. Plasma cell mucositis is a diagnosis of exclusion, to be differentiated from other infective, reactive, autoimmune, allergic and neoplastic disorders with plasma cell infiltrates. Management includes topical, intralesional, systemic corticosteroids and debulking procedures. Regular follow-up is essential due to the possibility of its clinical persistence and chances of malignant transformation.</p>

show abstract

Section: Discussionsupporting

confidence: 49%

Plasma cell mucositis masquerading as squamous cell carcinoma- a surgical dilemma: a rare case report and review of literature

Gopal

Singh

et al. 2022

Int J Otorhinolaryngol Head Neck Surg

View full text Add to dashboard Cite

show abstract

“…Plasm acanthoma is a subset of reactive plasma cell proliferation disorders characterized by benign dermal infiltration of polyclonal mature plasma cells (1). The etiology of reactive plasmacytosis, including plasm acanthoma, is obscure while it has been suggested to be a nonspecific reactive inflammatory response to allergens or exogenous agents, including insect bite, trauma, chronic irritation, Candi dial infection, subclinical infections secondary to low levels of serum and secretory IgA, poor hygiene and moisture (6,7). In addition, the influence of T cells and macrophages on B cell growth and differentiation has been reported to be associated with plasma cell cheilitis (8).…”

Section: Discussionmentioning

confidence: 99%

“…The long-term prognosis of patients with reactive plasma cell proliferation disorders is generally good. There is no report of progression to a malignancy up to date (7). There is also one report of spontaneous improvement of plasmoacanthoma; however, it has recurred after 7 years (19).…”

Section: Discussionmentioning

confidence: 99%

Perianal Plasmoacanthoma After BCG-Immunotherapy: Case Report and Review of Literature

Roohaninasab¹,

Goodarzi²,

Chalangari³

et al. 2022

ACTA

View full text Add to dashboard Cite

Plasmoacanthoma is a rare verrucous tumor classified as a form of reactive plasmacytosis. We present the first reported case of plasmoacanthoma following exposure to bacillus Calmette-Guérin (BCG) and a comprehensive review of the literature to better illustrate the patients’ characteristics and proposed risk factors, clinical features, diagnosis, treatment, and outcome of current reports. A 64-year-old female presented with a perianal hyperkeratotic plaque and diffused inflammatory macerated erosions in the intergluteal cleft and adjacent to the plaque after intravesical BCG immunotherapy. Laboratory studies disclosed systemic abnormalities and local infection or malignancies. Biopsy showed intradermal polyclonal plasma cell infiltration with acanthosis. The lesions were successfully treated with carbon dioxide laser ablation followed by the combination of pulsed dye laser and intralesional corticosteroid. Diagnosis of cutaneous reactive plasmacytosis should be confirmed by excluding the systemic causes of plasmacytosis and malignancies. It responds well to intralesional corticosteroids; however, in severe cases and large sizes, other treatments such as carbon dioxide laser ablation and pulsed dye laser should be considered as a combined therapy. Identification of causative factors is impractical while skin irritants with subsequent inflammation seem to be involved; as in the current report, BCG contact with skin initialized the pathologic process.

show abstract

“…The etiology of laryngeal plasmacytosis remains largely unknown and has been rarely reported except in conjunction with oral plasma cell gingivitis. 2 Associating with immune-mediated disease, long-term denture wear, and smoking has been suggested. 1,4 It is notable, however, that the patient in this case has no known history of these suggested risk factors.…”

Section: Discussionmentioning

confidence: 99%

“…2 Diagnosis of MMP can be challenging due to similarities in mucosal changes to other inflammatory conditions including fungal infection, lichen planus, and sarcoidosis. 2 Variations in mucosal changes include papillomatous and nodular presentations that can mimic squamous cell carcinoma. 1 Histologic features specific to MMP include epithelial hyperplasia and subepithelial infiltration of polytypic plasma cells with positivity for kappa and lambda light chains.…”

Section: Introductionmentioning

confidence: 99%

Laryngeal Plasmacytosis Responsive to Inhaled Budesonide

McLennan

Jeffery

2022

The Laryngoscope

View full text Add to dashboard Cite

Mucous membrane plasmacytosis (MMP) is rare condition characterized by diffuse plasma cell infiltration of upper aerodigestive tract mucosa. It results in epithelial hyperplasia that has a classic papillary appearance. We describe a case of MMP primarily affect laryngeal and oropharyngeal mucosa resulting in progressive airway obstruction. We highlight airway management and histopathology. The patient had near complete clinical response with inhaled budesonide, which has not yet been described as a treatment option in the literature.

show abstract

Mucous membrane plasmacytosis: A case report and review of the literature

Cited by 42 publications

References 0 publications

Plasma cell mucositis masquerading as squamous cell carcinoma- a surgical dilemma: a rare case report and review of literature

Plasma cell mucositis masquerading as squamous cell carcinoma- a surgical dilemma: a rare case report and review of literature

Perianal Plasmoacanthoma After BCG-Immunotherapy: Case Report and Review of Literature

Laryngeal Plasmacytosis Responsive to Inhaled Budesonide

Contact Info

Product

Resources

About