Mucous membrane pemphigoid–otorhinolaryngological manifestations: a retrospective cohort study

Madgar, Ory; Baniel, Alain; Yarom, Noam; Glikson, Eran; Zeeli, Tal; Sprecher, Eli; Alon, Eran E.

doi:10.1007/s00405-020-05812-3

Cited by 8 publications

(9 citation statements)

References 13 publications

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“…The first case of MMP was reported by Wickmann in 1794, in a female patient (9). MMP is more commonly observed in women than men with a male to female ratio of nearly 2:1 (1,4). The elderly population is most commonly affected by the disease, the majority of patients were in the age range of 60 to 80 years (5).…”

Section: Discussionmentioning

confidence: 99%

“…Cutaneous lesions on the head and upper trunk can be seen in a quarter of patients with MMP (1). The oral and conjunctival mucosa are most frequently affected in MMP, followed by involvement of nasal, oropharyngeal, laryngeal, esophageal and anogenital mucosa (1). The gingiva is generally one of the oral 7 sites with the greatest incidence after the palate and the buccal mucosa (10).…”

Section: Discussionmentioning

confidence: 99%

“…Mucous membrane pemphigoid (MMP) is a rare autoimmune, chronic inflammatory disease which affects mucous membranes, most commonly the oral and conjunctival, but also nasal, oropharyngeal, laryngeal, esophageal and anogenital, with or without skin involvement (1,2,3). MMP lesions are prone to infection causing fibrosis and granulation tissue formation, they often heal with scars which can cause permanent disfigurement and complications such as dysphagia and blindness (1,4). That is the reason why synonyms for MMP in the literature include benign mucous membrane pemphigoid, but also cicatricial (scarring) pemphigoid and ocular cicatricial pemphigoid.…”

Section: Introductionmentioning

confidence: 99%

“…That is the reason why synonyms for MMP in the literature include benign mucous membrane pemphigoid, but also cicatricial (scarring) pemphigoid and ocular cicatricial pemphigoid. The incidence is 1-5 cases per million individuals (1). Elderly females are commonly affected.…”

Section: Introductionmentioning

confidence: 99%

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Mucous membrane pemphigoid - a report of four cases

et al. 2023

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Introduction. Mucous membrane pemphigoid (MMP) is a rare autoimmune, chronic inflammatory disease which affects mucous membranes, most commonly the eyes and 3 mouth, with or without skin involvement. It is a complex disease with several complications including scarring, especially on conjunctival mucosa that can lead to visual loss. Case report. We report four patients (two men and two women) with MMP. In all patients the disease started in their seventies. The diagnosis was confirmed on the basis of clinical appearance, histology, direct and indirect immunofluorescence studies, indirect split skin technique and ELISA test. The majority of lesions were on the gums and buccal mucosa, one patient had laryngeal involvement and a lesion on the umbilicus. No ocular involvement and no malignancy were detected. Direct immunofluorescence tests revealed continuous linear IgG deposition in the basal membrane zone in two patients, and they were treated with oral nicotinamide and tetracycline hydrochloride. In two patients we detected IgG along with IgA linear deposition; they received treatement with methylprednisolone. Complete remission was achieved in all patients. Conclusion. Early diagnosis as well as a multidisciplinary therapeutic approach is necessary for the MMP treatment in long term disease control and reduction of the disease-related complications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mucous membrane pemphigoid - a report of four cases

et al. 2023

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“…Most patients have oral involvement only, but skin, genital, ocular, laryngeal, or nasal lesions can be present. Patients with extraoral manifestations are considered "high risk" patients and may require more aggressive treatment [7]. Oral lesions are frequently the first manifestation and precede other systemic manifestations [8].…”

Section: Introductionmentioning

confidence: 99%

Oral Pemphigoid Recalcitrant Lesion Treated with PRGF Infiltration. Case Report

et al. 2021

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Mucous membrane pemphigoid (MMP) is a heterogeneous group of chronic autoimmune subepithelial blistering diseases. Oral involvement is present in almost all patients, may represent the onset of the disease, and causes different degrees of pain, dysphagia, soreness, and bleeding. Treatment is based on systemic and/or oral corticoids, or other immunosuppressants. Occasionally, oral lesions can show a poor response to standard treatments. We present the case of a 61-year-old female patient with a painful extensive MMP oral ulcerative lesion recalcitrant to previous systemic azathioprine and local triamcinolone treatment, which was successfully treated in a novel way using PRGF infiltrations as adjuvant. After four weekly infiltrations, pain was reduced from 10 to 0 in a VAS and the lesion was completely healed. The patient continued with a low dose maintenance immunosuppressive treatment (prednisone 5 mg/day PO), and after 13 months of follow-up, there was no relapse of the lesion and no side effects. Although future research is necessary to confirm these observations, PRGF could be a useful adjuvant for the management of extensive mucous membrane pemphigoid oral lesions.

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Immunosuppresants/dapsone/rituximab

2020

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Mucous membrane pemphigoid–otorhinolaryngological manifestations: a retrospective cohort study

Cited by 8 publications

References 13 publications

Mucous membrane pemphigoid - a report of four cases

Mucous membrane pemphigoid - a report of four cases

Oral Pemphigoid Recalcitrant Lesion Treated with PRGF Infiltration. Case Report

Immunosuppresants/dapsone/rituximab

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