Mucous membrane pemphigoid: are laminin 5 antibodies a risk factor for laryngeal involvement?

Abstract

MMP have marked laryngeal involvement. Therefore, we would suggest that clinicians should be aware that laryngeal involvement is not a rare complication of lam332 MMP and to monitor it carefully as it can be life-threatening. In addition, larger studies are called for on the use of mitomycin C in lam332 laryngeal disease.

Immunofluorescence serration pattern analysis as a diagnostic criterion in antilaminin‐332 mucous membrane pemphigoid: immunopathological findings and clinical experience in 10 Dutch patients

“…Airway obstruction due to pharyngeal and laryngeal involvement is a serious complication that is seen more in anti-LN-332 MMP than in other forms of MMP. 28,29 First manifestations are aphonia (loss of voice) due to oedema, erosions and ulcerations of the supraglottic area. This is followed by scarring of the larynx, and acute upper airway obstruction due to initial laryngeal oedema may occur, necessitating tracheotomy.…”

“…Airway obstruction due to pharyngeal and laryngeal involvement is a serious complication that is seen more in anti‐LN‐332 MMP than in other forms of MMP 28,29 . First manifestations are aphonia (loss of voice) due to oedema, erosions and ulcerations of the supraglottic area.…”

Immunological methods for the diagnosis of oral mucosal diseases

“…IgG autoantibodies against laminin 332 are significantly associated with more severe MMP, such as MMP with pharyngolaryngeal and oropharyngolaryngeal involvement, which may be life-threatening. 47,92,93 Laminin 332 may have a correlation with tumours; patients with MMP with autoantibodies against laminin 332 showed a high mortality and only a minority go into remission. 94 For detecting anti-laminin 332 antibodies, the most sensitive method is IP; nevertheless, IB of human keratinocyte extracellular matrix is a practical alternative.…”

Exploring beyond the oral mucosa in patients affected with autoimmune blistering diseases: the importance of endoscopic procedures

“…d,e). The most aggressive involvement of the larynx in MMP is associated with the presence of circulating laminin 5 (laminin 332) autoantibodies, severe ocular lesions, and/or multifocal disease (more than three affected sites other than NT) . Therefore, the frequency and morbidity in NT involvement is different in PV and MMP (Table ).…”