Mucosal vitamin D signaling in inflammatory bowel disease

Kellermann, Lauge; Jensen, Kim B.; Bergenheim, Fredrik; Gubatan, John; Chou, Naomi D.; Moss, Alan C.; Nielsen, Ole Haagen

doi:10.1016/j.autrev.2020.102672

Cited by 35 publications

(27 citation statements)

References 166 publications

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“…Other factors that may contribute to the depletion of vitamin D in PLE patients include: ongoing systemic inflammation, reduced dietary intake of vitamin D and increased vitamin D metabolism. Additionally, 1,25(OH) 2 D has immunomodulatory effects which may support mucosal health (Kellermann et al 2020). Due to this immunomodulatory role, it is also possible that patients with PLE develop this disease in part due to their 25(OH)D deficiency (Ananthakrishnan 2016).…”

Section: Gastrointestinal Diseasesmentioning

confidence: 99%

Vitamin D metabolism and disorders in dogs and cats

Clarke

Hurst

Mellanby

2021

J of Small Animal Practice

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Vitamin D plays an important role in regulating calcium metabolism and in the development and maintenance of skeletal health of companion animals. There is also a growing interest in understanding the role vitamin D plays in non-skeletal health in both human and veterinary patients. This review provides an update of our current understanding of vitamin D biology in dogs and cats and gives an overview of how vitamin D metabolism can be assessed in companion animals. Congenital and acquired vitamin D disorders are then summarised before the review concludes with a summary of recent studies which have explored the role of vitamin D in the development and outcomes of non-skeletal diseases of dogs and cats.

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Section: Gastrointestinal Diseasesmentioning

confidence: 99%

Vitamin D metabolism and disorders in dogs and cats

Clarke

Hurst

Mellanby

2021

J of Small Animal Practice

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“…It has been found that the induction of antimicrobial peptide genes’ expression by vitamin D [ 9 ] explores the ‘antibiotic’ effect of vitamin D. Increasing research projects have unraveled the important role of vitamin D in the regulation of innate and adaptive immunity [ 10 , 11 , 12 ]. 1,25-dihydroxyvitamin D3 (1,25D3), the active form of vitamin D, induced the expression of two AMPs, hBD-2 and cathelicidin [ 13 , 14 ], in several cultured cells in response to bacterial pathogens.…”

Section: Introductionmentioning

confidence: 99%

The Cooperation of Bifidobacterium longum and Active Vitamin D3 on Innate Immunity in Salmonella Colitis Mice via Vitamin D Receptor

Huang

2021

Microorganisms

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Salmonella spp. remains a major public health problem for the whole world. Intestinal epithelial cells serve as an essential component of the mucosal innate immune system to defend against Salmonella infection. Our in vitro studies showed probiotics and active vitamin D have similar effects on innate immunity in Salmonella-infected intestinal epithelial cells, including antimicrobial peptide and inflammatory responses, to protect the host against infection while downregulating detrimental overwhelming inflammation. Hence, we investigated the synergistic effects of probiotics and active vitamin D on Salmonella colitis and translocation to liver and spleen by in vitro and in vivo studies. The Salmonella colitis model is conducted with 6–8 w/o male C57BL/6 mice: Streptomycin (20 mg/mouse p.o.)-pretreated C57BL/6 mice are mock infected with sterile PBS or infected orally with 1 × 108 CFU of a S. Typhimurium wild-type strain SL1344 for 48 h. The mice in the treated groups received 1, 25D daily (0.2 ug/25 g/d) and/or 1 × 108 CFU of probiotics, Lactobacillus rhamnosus GG (LGG) and Bifidobacterium longum (BL) by intragastric administration for 14 days. The in vivo study demonstrated the combination of probiotic Bifidobacterium longum and active vitamin D3 had the synergistic effects on reducing the severity of Salmonella colitis and body weight loss in C57BL/6 mice by reducing cecal inflammatory mIL-6, mIL-8, mTNF-α and mIL-1β mRNA responses, blocking the translocation of bacteria while enhancing the antimicrobial peptide mhBD-3 mRNA in comparison to the infection only group. However, LGG did not have the same synergistic effects. It suggests the synergistic effects of Bifidobacterium longum and active vitamin D on the antibacterial and anti-inflammatory responses in Salmonella colitis. Therefore, our in vivo studies demonstrated that the combination of probiotic Bifidobacterium longum and active vitamin D3 has the synergistic effects on reducing the severity of Salmonella colitis via the suppression of inflammatory responses, and blocking the translocation of bacteria through the enhancement of antimicrobial peptides.

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“…In view of the above, it is not surprising that dysregulation in these components, such as defective expression of defensins, upregulation of claudin-2, or increased apoptosis of epithelial cells, can contribute to the disruption of the mucosal barrier, as reported in IBD and SpA patients [34][35][36][37][38]. In particular, it has been hypothesized that, in SpA patients, the increased intestinal permeability, probably induced by genetic factors (HLA-B27), could induce a disruption of the basal membrane, hyperplasia of goblet cells, and activation of Paneth cells producing high levels of anti-microbial peptides (AMPs) and IL-23, leading to exaggerated antigenic stimulation and activation of effector T-cells of the intestinal mucosa [27,[39][40][41][42][43].…”

Section: Vitamin D and Intestinal Permeabilitymentioning

confidence: 99%

“…Deficits in the autophagy mechanism can alter Paneth cell function and contribute to gut inflammation and dysbiosis. Low levels of intestinal epithelial VDR correlate with a reduced expression of the autophagy gene ATG16L1 and impaired antimicrobial function of Paneth cells [47,60] and can induce gut dysbiosis in patients with IBD [34].…”

Section: Vitamin D Mucosal Immunity and Immunomodulationmentioning

confidence: 99%

Vitamin D Signaling in Gastro-Rheumatology: From Immuno-Modulation to Potential Clinical Applications

Pagnini

Picchianti-Diamanti

Bruzzese

et al. 2021

IJMS

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In the last decades, the comprehension of the pathophysiology of bone metabolism and its interconnections with multiple homeostatic processes has been consistently expanded. The branch of osteoimmunology specifically investigating the link between bone and immune system has been developed. Among molecular mediators potentially relevant in this field, vitamin D has been recently pointed out, and abnormalities of the vitamin D axis have been described in both in vitro and in vivo models of inflammatory bowel diseases (IBD) and arthritis. Furthermore, vitamin D deficiency has been reported in patients affected by IBD and chronic inflammatory arthritis, thus suggesting the intriguing possibility of impacting the disease activity by the administration vitamin D supplements. In the present review, the complex interwoven link between vitamin D signaling, gut barrier integrity, microbiota composition, and the immune system was examined. Potential clinical application exploiting vitamin D pathway in the context of IBD and arthritis is presented and critically discussed. A more detailed comprehension of the vitamin D effects and interactions at molecular level would allow one to achieve a novel therapeutic approach in gastro-rheumatologic inflammatory diseases through the design of specific trials and the optimization of treatment protocols.

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Mucosal vitamin D signaling in inflammatory bowel disease

Cited by 35 publications

References 166 publications

Vitamin D metabolism and disorders in dogs and cats

Vitamin D metabolism and disorders in dogs and cats

The Cooperation of Bifidobacterium longum and Active Vitamin D3 on Innate Immunity in Salmonella Colitis Mice via Vitamin D Receptor

Vitamin D Signaling in Gastro-Rheumatology: From Immuno-Modulation to Potential Clinical Applications

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