Mucosal Schwann cell hamartoma: a benign and little-known entity

Barreiro, Violeta Mauriz; Alonso, Marta Ramos; López, Martín Fernández; Castillo, Diana Alejandra Rivera; Tonder, Cristina Durana; Cibreiro, Carmen Pradera

doi:10.17235/reed.2023.9652/2023

Cited by 1 publication

(1 citation statement)

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“…Surveillance colonoscopy intervals have yet to be widely studied in the literature, and this entity has limited guidelines for surveillance colonoscopy. Reports have discussed intervals ranging from one to five years in a few cases [17,18]. To date, no complications have been documented with this entity.…”

Section: Discussionmentioning

confidence: 99%

Schwann Cell Hamartoma Presenting as a Colonic Polyp: A Rare Case Report With a Literature Review

Altaf,

Javed,

Ghazanfar

et al. 2024

Cureus

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Mucosal Schwann cell hamartomas (MSCHs) are non-common noncancerous growths derived from Schwann cells in the peripheral nervous system, often found unexpectedly during routine colonoscopy examinations. These growths primarily occur in the colon, although they can also appear in the esophagus and are not linked to familial cancer syndromes. Diagnosis relies on specific histological characteristics and staining patterns. It is essential to distinguish MSCHs accurately since their appearance can closely resemble that of malignant tumors. Characteristically, these hamartomas test positive for S-100 protein but do not exhibit markers typical of other gastrointestinal growths, such as gastrointestinal stromal tumors (negative for KIT), leiomyomas (negative for smooth muscle actin), neurofibromas (negative for CD34), and perineuromas (negative for epithelial membrane antigen or claudin-1). This report discusses the case of a 48-year-old woman who was diagnosed with MSCH during a screening colonoscopy.

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Section: Discussionmentioning

confidence: 99%