Mucosal melanoma of nasal cavity and paranasal sinus

Dwivedi, Raghav C.; Dwivedi, Ravi C.; Kazi, Rehan; Kumar, Sumit; Agarwal, Saurabh

doi:10.4103/0973-1482.44293

Cited by 10 publications

(20 citation statements)

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“…Recent literature has suggested, however, that there may be a 50 to 75% initial response rate when radiotherapy alone is used. 1 It has not been shown definitively that there is a survival advantage with the addition of radio-or chemotherapy to surgery. One of our primary aims was to determine whether there is a statistically significant increase in survival with combined therapy versus single modality therapy.…”

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confidence: 99%

Survival in Sinonasal Melanoma: A Meta-analysis

Gore

Zanation

2012

J Neurol Surg B

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Sinonasal melanoma is an uncommon tumor which carries a poor prognosis and high rates of local and regional recurrence and distant metastasis. While surgical resection is the mainstay of treatment, the utility of multimodality therapy has not been well studied or established. We sought to better evaluate the optimal treatment modality for sinonasal melanoma. We reviewed 39 case reports involving 423 patients with sinonasal melanoma and present a meta-analysis comparing survival by treatment modality. The two-tailed p-value for survival by treatment modality was determined. The number of primary site/local, regional, and distant recurrences was determined where data was available. There was a nonsignificant increase in survival for patients treated with surgery?+?radiotherapy versus surgery alone. There was a statistically significant increase in survival for surgery?+?chemotherapy versus chemotherapy alone and versus surgery alone. Patients treated with combined surgery, radiation, and chemotherapy had a statistically shorter survival interval than patients treated with surgery?+?chemotherapy, which may reflect more advanced disease in patients treated with triple therapy. There was no statistically significant increase in survival found for the addition of radiation to surgery. This meta-analysis demonstrates that multimodality therapy, particularly the addition of chemo-or immunotherapy to surgery, may increase survival in a subset of patients. Radiation therapy did not appear to increase survival. There may be a significant increase in overall survival with combined modality therapy with surgery and chemo/immunotherapy versus single modality therapy. Level of evidence: III. Grade of recommendation: C.

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confidence: 99%

Survival in Sinonasal Melanoma: A Meta-analysis

Gore

Zanation

2012

J Neurol Surg B

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“…(Sanderson and Gaylis, 2007). Nose bleeding & blockage are 2 signs of this disease that are found in majority of the patients (Dwivedi et al, 2008;Dauer et al, 2008). A clinically evident mucosal malignant melanoma is based on its location & remote metastases are common if metastasis of the lymphatic node in neck occurs close later.…”

Section: Resultsmentioning

confidence: 99%

Malignant melanoma of the nasal mucosa

Anand¹,

Swain²

2020

ijrps

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Nose's Paranasal sinus & malignant melanoma are rarely seen, bold tumor with a prevalence rates of 0.68 percent across every malignant tumor. The neuroectodermal cells which are termed as Melanomas are found in skin's base layer, iris’s vascular intraocular coat, skin adnexa, & infrequently into outer covering of mucous. Blockage feeling of nose & bleeding from the nose are the symptoms which are most commonly reported, however patient may have symptoms that are nonspecific, leading to a delay in diagnosis which results in appropriate prediction of treatment's outcome. This study defines a 70 years female with the history of nose blockage feeling. Physicians suggest performing Nose’s CT scan, in which they came to know that large polypoidal portion in right nostril, extending to the nasopharynx, and eroded part of the sinus wall, septum and right medial pterygoid plate. Immunochemical study done revealed positive results for S100, vimentin, & HMB-45, which made the outcome suitable for tumor. An individual suffering from this will have no recurrence.

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“…Incidence of regional lymph node metastasis on presentation is about 5 to 15% with submandibular nodes being most commonly affected. About 10% of the patients may have distant metastasis on presentation [3].…”

Section: Discussionmentioning

confidence: 99%

Mucosal Malignant Melanoma of Nasal Cavity

Ghate¹,

Thomas²,

Shah³

et al. 2013

JCR

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Abstract:Mucosal malignant melanoma of the nasal cavity and paranasal sinuses is a rare entity. It is an unusual cause of nasal obstruction and epistaxis seen especially in elderly. This tends to be an aggressive tumor with poor prognosis because of distant metastasis and loco-regional recurrence. Surgical excision is the preferred treatment modality with adjuvant radiotherapy for selected cases with large bulky primary disease or regional lymph node metastasis. Immunotherapy is showing some promise and chemotherapy at present has a role only in palliation. Here we present a case of mucosal malignant melanoma in a 62 years old female that was treated by wide local excision after ruling out distant and local metastasis.

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Mucosal melanoma of nasal cavity and paranasal sinus

Cited by 10 publications

References 10 publications

Survival in Sinonasal Melanoma: A Meta-analysis

Survival in Sinonasal Melanoma: A Meta-analysis

Malignant melanoma of the nasal mucosa

Mucosal Malignant Melanoma of Nasal Cavity

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