Mucosal Immunity*

López, Marı́a C.

doi:10.1016/b978-0-08-046884-6.00611-4

Cited by 1 publication

(1 citation statement)

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“…28 In contrast, the lamina propria lymphocytes, which are scattered throughout the lamina propria underneath the epithelial layer, are more diverse in their cellular composition and resemble more those of other lymphatic organs. 29 iNKT cells can be detected in the mouse intestine at frequencies only slightly lower than in other peripheral organs, like the spleen and lymph nodes (stomach, 30 small intestine, [31][32][33] large intestine [33][34][35][36][37] ). Approximately 65% (BALB/c mice) to 85% (C57BL/6 mice) of intestinal iNKT cells are NKT1 cells, with the rest largely being NKT2 cells, and no differences in this distribution were noted for IELs versus lamina propria lymphocytes.…”

Section: (3) Mucus Production and Glycosylationmentioning

confidence: 99%

The interaction between invariant Natural Killer T cells and the mucosal microbiota

Hapil¹,

Wingender

2018

Immunology

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SummaryThe surface of mammalian bodies is colonized by a multitude of microbial organisms, which under normal conditions support the host and are considered beneficial commensals. This requires, however, that the composition of the commensal microbiota is tightly controlled and regulated. The host immune system plays an important role in the maintenance of this microbiota composition. Here we focus on the contribution of one particular immune cell type, invariant Natural Killer T (iNKT) cells, in this process. The iNKT cells are a unique subset of T cells characterized by two main features. First, they express an invariant T-cell receptor that recognizes glycolipid antigens presented by CD1d, a non-polymorphic major histocompatibility complex class I-like molecule. Second, iNKT cells develop as effector/memory cells and swiftly exert effector functions, like cytokine production and cytotoxicity, after activation. We outline the influence that the mucosal microbiota can have on iNKT cells, and how iNKT cells contribute to the maintenance of the microbiota composition.

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