Mucosal Immunity and the Onset of Allergic Disease

Ohshima, Yusei

doi:10.2332/allergolint.13-rai-0585

Cited by 7 publications

(4 citation statements)

References 118 publications

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“…To gain insights into the mechanisms induced by a cocoa diet, we focused on the composition and some functional aspects of MLN cells, due to their important role in oral tolerance [ 39 , 40 ]. The transport of the antigen captured by antigen-presenting cells from lamina propria into MLN is a key point in the induction of oral tolerance [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Cocoa Diet Prevents Antibody Synthesis and Modifies Lymph Node Composition and Functionality in a Rat Oral Sensitization Model

et al. 2016

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Cocoa powder, a rich source of polyphenols, has shown immunomodulatory properties in both the intestinal and systemic immune compartments of rats. The aim of the current study was to establish the effect of a cocoa diet in a rat oral sensitization model and also to gain insight into the mesenteric lymph nodes (MLN) activities induced by this diet. To achieve this, three-week-old Lewis rats were fed either a standard diet or a diet with 10% cocoa and were orally sensitized with ovalbumin (OVA) and with cholera toxin as a mucosal adjuvant. Specific antibodies were quantified, and lymphocyte composition, gene expression, and cytokine release were established in MLN. The development of anti-OVA antibodies was almost totally prevented in cocoa-fed rats. In addition, this diet increased the proportion of TCRγδ+ and CD103+CD8+ cells and decreased the proportion of CD62L+CD4+ and CD62L+CD8+ cells in MLN, whereas it upregulated the gene expression of OX40L, CD11c, and IL-1β and downregulated the gene expression of IL-17α. In conclusion, the cocoa diet induced tolerance in an oral sensitization model accompanied by changes in MLN that could contribute to this effect, suggesting its potential implication in the prevention of food allergies.

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Section: Discussionmentioning

confidence: 99%

Cocoa Diet Prevents Antibody Synthesis and Modifies Lymph Node Composition and Functionality in a Rat Oral Sensitization Model

et al. 2016

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“…It is now commonly accepted that its constitutive impairment leading to increased antigen delivery from the intestinal lumen to the gut submucosa is one of the processes preceding the induction of autoimmune diseases targeting extraintestinal organs (48,49) whose prevalence is increasing in prosperous urban populations (19,20,50) and is related to microbial encounters (33). Interestingly, favorable socioeconomic factors, such as enriched dietary habits or increased levels of hygiene are presumably the main factors driving the E. coli population shift from phylogenetic group A to phylogenetic group B2, including colibactin-producing strains (51).…”

Section: Discussionmentioning

confidence: 99%

Oral Tolerance Failure upon Neonatal Gut Colonization with Escherichia coli Producing the Genotoxin Colibactin

et al. 2015

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fThe intestinal barrier controls the balance between tolerance and immunity to luminal antigens. When this finely tuned equilibrium is deregulated, inflammatory disorders can occur. There is a concomitant increase, in urban populations of developed countries, of immune-mediated diseases along with a shift in Escherichia coli population from the declining phylogenetic group A to the newly dominant group B2, including commensal strains producing a genotoxin called colibactin that massively colonized the gut of neonates. Here, we showed that mother-to-offspring early gut colonization by colibactin-producing E. coli impairs intestinal permeability and enhances the transepithelial passage of luminal antigen, leading to an increased immune activation. Functionally, this was accompanied by a dramatic increase in local and systemic immune responses against a fed antigen, decreased regulatory T cell population, tolerogenic dendritic cells, and enhanced mucosal delayed-type hypersensitivity response. Conversely, the abolition of colibactin expression by mutagenesis abrogates the alteration of oral tolerance induced by neonatal colonization by E. coli. In conclusion, the vertical colonization by E. coli producing the genotoxin colibactin enhances intestinal translocation and subsequently alters oral tolerance. Thus, early colonization by E. coli from the newly dominant phylogenetic group B2, which produces colibactin, may represent a risk factor for the development of immune-mediated diseases.

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“…Various studies have shown that equilibrium of microbiota in epithelial barrier is vital for protection against allergic sensitization and disease development ( Iweala and Nagler, 2019 ; Ohshima, 2013 ). Studies have demonstrated that shifting of a usual diet towards high fat, low fiber, highly processed food, and indiscriminate use of antibiotics can cause microbiome dysbiosis ( Weissis and Hennet, 2017 ; Wypych and Marsland, 2018 ).…”

Section: Host and Tick Factors Contributing To Agsmentioning

confidence: 99%

Tick Saliva and the Alpha-Gal Syndrome: Finding a Needle in a Haystack

Sharma

Karim

2021

Front. Cell. Infect. Microbiol.

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Ticks and tick-borne diseases are significant public health concerns. Bioactive molecules in tick saliva facilitate prolonged blood-feeding and transmission of tick-borne pathogens to the vertebrate host. Alpha-gal syndrome (AGS), a newly reported food allergy, is believed to be induced by saliva proteins decorated with a sugar molecule, the oligosaccharide galactose-⍺-1,3-galactose (α-gal). This syndrome is characterized by an IgE antibody-directed hypersensitivity against α-gal. The α-gal antigen was discovered in the salivary glands and saliva of various tick species including, the Lone Star tick (Amblyomma americanum). The underlying immune mechanisms linking tick bites with α-gal-specific IgE production are poorly understood and are crucial to identify and establish novel treatments for this disease. This article reviews the current understanding of AGS and its involvement with tick species.

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Mucosal Immunity and the Onset of Allergic Disease

Cited by 7 publications

References 118 publications

Cocoa Diet Prevents Antibody Synthesis and Modifies Lymph Node Composition and Functionality in a Rat Oral Sensitization Model

Cocoa Diet Prevents Antibody Synthesis and Modifies Lymph Node Composition and Functionality in a Rat Oral Sensitization Model

Oral Tolerance Failure upon Neonatal Gut Colonization with Escherichia coli Producing the Genotoxin Colibactin

Tick Saliva and the Alpha-Gal Syndrome: Finding a Needle in a Haystack

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