Mucosal Disorders with Oral Epithelial Dysplasia risk – Development of a simple screening tool for general health care setting

Thomas, Valsa; Devi, Swami; Jeyaseelan, Visalakshi; Jeyseelan, L.

doi:10.1016/j.oraloncology.2012.02.011

Cited by 12 publications

(14 citation statements)

References 22 publications

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“…Majority of oral cancers develop from oral premalignancies or are associated with it. [ 1 ] The concept of “early diagnosis leads to improved prognosis” is based on the fact that carcinoma develops over a long period of time, going through intermediate stages of different biological significance and the treatment at the pre-invasive stage offers the best prognosis. [ 2 ]…”

Section: Introductionmentioning

confidence: 99%

Acetic acid as an adjunct vital stain in diagnosis of tobacco-associated oral lesions: A pilot study

Vinuth

Agarwal

Kale

et al. 2015

J Oral Maxillofac Pathol

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Background:One of the most important risk factors for oral precancer and cancer in India is the use of tobacco. In chronic tobacco users, the mucosa may appear clinically healthy, however, changes are observed histologically. Screening of such tobacco users for an early diagnosis is, therefore, of paramount importance. Several adjunctive diagnostic modalities have been used in the past, but none has been conclusively validated as confirmative and cost-effective screening methodology. The aim of this study was to evaluate the use of 5% acetic acid as a vital staining agent in tobacco-associated oral lesions.Materials and Methods:The study subjects were divided into two groups. Group I (n = 40) subjects with a history of chronic tobacco use and clinically apparent normal mucosa. Group II (n = 40) subjects suspected of having oral cancer, 5% acetic acid was applied to the mucosa/lesions, followed by incisional biopsy for confirmatory diagnosis.Results:The sensitivity and specificity for Groups I and II were 97%, 50% and 95%, 60%, respectively. Positive predictive value (PPV) and negative predictive value (NPV) of Group I were 0.95 and 0.66. Group II showed PPV and NPV of 0.95 and 0.60.Conclusion:The results of this study suggest that acetic acid holds promise for future. Hence, further studies are needed to be undertaken on a large scale to assess its potential as a screening tool for high-risk individuals and oral cancer.

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Section: Introductionmentioning

confidence: 99%

Acetic acid as an adjunct vital stain in diagnosis of tobacco-associated oral lesions: A pilot study

Vinuth

Agarwal

Kale

et al. 2015

J Oral Maxillofac Pathol

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“…O câncer de mucosa oral é considerado um problema de saúde pública em todo o mundo (Thomas et al, 2012). As estimativas recentes apontam para a ocorrência de cerca de 300 mil casos novos e 145 mil óbitos no mundo, no ano de 2012 (Brasil, 2014).…”

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“…O câncer da mucosa oral é geralmente precedido por alterações visíveis da mucosa oral, o que permite aos clínicos detectar e tratar precocemente ainda nos estágios precoces da sua evolução (Thomas et al, 2012).…”

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“…O câncer da mucosa oral é um problema de saúde pública (Lee et al, 2001;Warnakulasuriya, 2009;Thomas et al, 2012). Segundo a literatura, esta doença acomete mais comumente homens que mulheres, com idade acima de 50 anos (Warnakulasuriya, 2009;Bagan, 2009;Eisenberg, 2011;Mishra, 2012;Brasil, 2014).…”

Section: Análise Histopatológicaunclassified

“…Portanto, o câncer da mucosa oral é uma doença letal para mais de 50% dos casos diagnosticados anualmente. Isto ocorre principalmente porque estes casos se encontram em estágio avançado no momento do diagnóstico devido à falta de sensibilização do paciente para os sinais e sintomas da doença e consequentemente ao atraso do paciente em buscar o profissional no primeiro sinal ou sintoma da doença ou até devido à dificuldade em se diagnosticar as lesões em seu estágio inicial, o que requer a implantação de mais programas de prevenção e detecção precoce por parte dos serviços de saúde (Warnakulasuriya, 2009;Thomas et al, 2012).…”

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Análise histopatológica de lesões leucoqueratósicas da mucosa oral avaliadas pelos exames de luminescência, cromoscopia e microscopia confocal reflectante

Bezerra¹

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Screening tool could help oral cancer detection

2012

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Mucosal Disorders with Oral Epithelial Dysplasia risk – Development of a simple screening tool for general health care setting

Cited by 12 publications

References 22 publications

Acetic acid as an adjunct vital stain in diagnosis of tobacco-associated oral lesions: A pilot study

Acetic acid as an adjunct vital stain in diagnosis of tobacco-associated oral lesions: A pilot study

Análise histopatológica de lesões leucoqueratósicas da mucosa oral avaliadas pelos exames de luminescência, cromoscopia e microscopia confocal reflectante

Screening tool could help oral cancer detection

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