Mucosal biomarkers for endometrial receptivity: A promising yet underexplored aspect of reproductive medicine

Jain, Mark; Samokhodskaya, L М; Mladova, Elena; Панина, О.Б.

doi:10.1080/19396368.2021.1985186

Cited by 9 publications

(5 citation statements)

References 72 publications

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“…A review summarizing evidence regarding endometrial expression originating from the same patient in different endometrial phases reported that only two genes, namely osteopontin (SPP1) and interleukin 15 (IL-15), were differentially expressed [ 34 ]. A recent study reviewed numerous possible mucosal biomarkers, highlighting the importance of urocortin, activin A, interleukin 1beta (IL-1β), tumor necrosis factor alpha (TNF-α), interferon gamma-induced protein 10 (IP-10), and monocyte chemoattractant protein 1 (MCP-1), as well as oxidative stress biomarkers [ 39 ]. Furthermore, numerous genetic variations, as well as differential expression levels of genes or of non-coding RNAs, have been investigated as biomarkers of endometrial receptivity.…”

Section: Resultsmentioning

confidence: 99%

Commercially Available Molecular Approaches to Evaluate Endometrial Receptivity: A Systematic Review and Critical Analysis of the Literature

Maziotis

Kalampokas

Giannelou³

et al. 2022

Diagnostics

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Despite the advances in the field of reproductive medicine, implantation failure represents a challenging condition affecting 10–30% of patients subjected to in vitro fertilization (IVF). Research has focused on the identification of molecules playing crucial roles in endometrial receptivity, with the aim of designing predictive tools for efficient detection of the implantation window. To that end, novel molecular genomic and transcriptomic approaches have been introduced as promising tools to enable personalized approaches with the aim of optimizing embryo transfer dating. However, the clinical value of these approaches remains unclear. The aim of this study is to provide a systematic review and critical analysis of the existing evidence regarding the employment of commercially available novel approaches to evaluate endometrial receptivity. An Embase and PubMed/Medline search was performed on 1 February 2022. From the 475 articles yielded, only 27 were included and analyzed. The considerable heterogeneity of the included articles indicates the uniqueness of the implantation window, showcasing that the optimal time for embryo transfer varies significantly between women. Moreover, this study provides information regarding the technical aspects of these advanced molecular tools, as well as an analysis of novel possible biomarkers for endometrial receptivity, providing a basis for future research in the field.

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Section: Resultsmentioning

confidence: 99%

Commercially Available Molecular Approaches to Evaluate Endometrial Receptivity: A Systematic Review and Critical Analysis of the Literature

Maziotis

Kalampokas

Giannelou³

et al. 2022

Diagnostics

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“…Moreover, it is speculated that the decrease in LIF levels may be one of the underlying pathogenetic pathways [41]. Even if in current practice it is accepted that normal receptivity cannot be characterized by a single factor, changes in LIF levels remain a visible marker of an important impairment at this level [44].…”

Section: Discussionmentioning

confidence: 99%

Killer Cell Immunoglobulin-like Receptor Genotypes and Reproductive Outcomes in a Group of Infertile Women: A Romanian Study

Surcel,

Neamtiu,

Muresan

et al. 2023

Diagnostics

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A growing body of evidence suggests that endometrial immune disorders may be responsible for endometrial dysfunctions that can lead to gynecological and obstetrical pathology. The aim of this study was to explore the potential relationship between different killer cell immunoglobulin-like receptor (KIR) genotypes and reproductive outcomes. We conducted a prospective cohort study that included 104 infertile patients undergoing an in vitro fertilization procedure. All participants underwent clinical and ultrasound examination, genetic evaluation (KIR genotyping), endometrial washing fluid sampling for cytokine determination, endometrial tissue sampling for histologic assessment and hysteroscopic evaluation. Our analysis showed statistically significant lower levels of uterine cytokines TNF-α (p = 0.001) and IL-1beta (p = 0.000) in the KIR AA genotype group as compared to KIR AB and BB among study participants with chronic endometritis. The study results suggest that the KIR AA genotype population subgroups may be more susceptible to developing endometrial disorders such as chronic endometritis. The changes in the behavior of NK cells seem to be subtle and expressed as an altered regulatory pattern.

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“…The imbalance of inflammatory factors and immune cell profiles is a notable phenomenon in patients with adverse pregnancy history [119,120]. Such abnormalities could significantly impact pregnancy outcomes by damaging ovarian function [121], inhibiting endometrial receptivity [122], hindering trophoblast development, and interfering with immune tolerance at the maternal-fetal interface [65].…”

Section: Low-grade Inflammatory Activationmentioning

confidence: 99%

Connecting the dots: the role of fatigue in female infertility

Li,

Huang,

Wei

et al. 2024

Reprod Biol Endocrinol

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Fatigue, an increasingly acknowledged symptom in various chronic diseases, has garnered heightened attention, during the medical era of bio-psycho-social model. Its persistence not only significantly compromises an individual’s quality of life but also correlates with chronic organ damage. Surprisingly, the intricate relationship between fatigue and female reproductive health, specifically infertility, remains largely unexplored. Our exploration into the existing body of evidence establishes a compelling link between fatigue with uterine and ovarian diseases, as well as conditions associated with infertility, such as rheumatism. This observation suggests a potentially pivotal role of fatigue in influencing overall female fertility. Furthermore, we propose a hypothetical mechanism elucidating the impact of fatigue on infertility from multiple perspectives, postulating that neuroendocrine, neurotransmitter, inflammatory immune, and mitochondrial dysfunction resulting from fatigue and its co-factors may further contribute to endocrine disorders, menstrual irregularities, and sexual dysfunction, ultimately leading to infertility. In addition to providing this comprehensive theoretical framework, we summarize anti-fatigue strategies and accentuate current knowledge gaps. By doing so, our aim is to offer novel insights, stimulate further research, and advance our understanding of the crucial interplay between fatigue and female reproductive health.

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Mucosal biomarkers for endometrial receptivity: A promising yet underexplored aspect of reproductive medicine

Cited by 9 publications

References 72 publications

Commercially Available Molecular Approaches to Evaluate Endometrial Receptivity: A Systematic Review and Critical Analysis of the Literature

Commercially Available Molecular Approaches to Evaluate Endometrial Receptivity: A Systematic Review and Critical Analysis of the Literature

Killer Cell Immunoglobulin-like Receptor Genotypes and Reproductive Outcomes in a Group of Infertile Women: A Romanian Study

Connecting the dots: the role of fatigue in female infertility

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