Mucosal Barrier Injury Central-Line–Associated Bloodstream Infections: What is the Impact of Standard Prevention Bundles?

Prospective Initiative to Reduce Mucosal Barrier Injuries and Bloodstream Infections in Patients With Hematologic Malignancy Receiving Inpatient Chemotherapy

“…After a period of unit education, post-test assessments noted that 89% of RNs felt confident in assessment and management of patients with MBI (Appendix Figs A2A and A2B, online only). 10,11 Nurses were also trained on WHO grading of mucositis and appropriate documentation in the electronic medical record (EMR). The incidence of MBI during the first PDSA remained stable.…”

“…Interventions to reduce MBI-LCBI are not standardized, and literature supporting interventions to mitigate these events is limited. Vaughan et al 11 retrospectively examined their CLABSI events to determine whether standard bundle protocols for central line care would reduce MBI-LCBI events and found a reduction in both MBI-and non-MBI-related events. Furthermore, Kemp et al 12 recently published their attempts to reduce CLABSI events through oral care and hygiene.…”

Levofloxacin prophylaxis for pediatric leukemia patients: Longitudinal follow‐up for impact on health care‐associated infections

“…2 Implementation of these strategies reduce the incidence of CLABSI among hospitalized patients, though to a lesser degree in pediatric patients with leukemia. [3][4][5] Many episodes of bacteremia in oncology patients occur with chemotherapy-associated neutropenia, mucositis, and translocation of organisms from oral or gastrointestinal mucosa, thus additional prevention measures have been investigated. [2][3][4][5][6] Studies of adult oncology patients have demonstrated that the use of prophylactic antibiotics during chemotherapy-induced neutropenia is effective in reducing infections, including bacteremia.…”

“…[3][4][5] Many episodes of bacteremia in oncology patients occur with chemotherapy-associated neutropenia, mucositis, and translocation of organisms from oral or gastrointestinal mucosa, thus additional prevention measures have been investigated. [2][3][4][5][6] Studies of adult oncology patients have demonstrated that the use of prophylactic antibiotics during chemotherapy-induced neutropenia is effective in reducing infections, including bacteremia. [7][8][9] Until recently, similar studies in pediatrics were limited to single-center or nonrandomized trials that yielded conflicting results.…”

Impacto da utilização do critério de infecção da corrente sanguínea associada a lesão da barreira mucosa em pacientes com tumores sólidos e neoplasias hematológicas

“…Estudos publicados, com populações oncológicas, sobre o impacto do uso do critério de ICS-LBM Lesão de Barreira MucosaApesar da evidente importância da utilização do critério de ICS-LBM para as definições de medidas preventivas mais específicas, é importante considerar que esta definição utiliza critérios epidemiológicos. Uma parcela destes casos pode, na verdade, tratar-se de infecção cuja fonte seja o CVC 72,68. Para avaliar esta possibilidade, Kamboj et al, em 2014, descreveram em seu estudo a possibilidade das ICS-LBM terem o foco da infecção no cateter.…”