Mucosal adjuvanticity and mucosal booster effect of colibactin-depleted probiotic
Escherichia coli
membrane vesicles
Hiroki Uchiyama,
Toshifumi Kudo,
Takehiro Yamaguchi
et al.
Abstract:There is a growing interest in development of novel vaccines against respiratory tract infections, due to COVID-19 pandemic. Here, we examined mucosal adjuvanticity and the mucosal booster effect of membrane vesicles (MVs) of a novel probiotic
E. coli
derivative lacking both flagella and potentially carcinogenic colibactin (Δ
flhD
Δ
clbP
). Δ
flhD
Δ
clbP
-derived MVs showed rather strong mucosal a… Show more
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