Mucosa-Associated Lymphoid Tissue Lymphoma Involving the Kidney and Renal Pelvis

Abstract

Mucosa-associated lymphoid tissue (MALT) lymphomas are a distinctive group of B-cell lymphomas. These lymphomas arise from various anatomic sites and are mainly seen in the gastrointestinal tract, but the primary involvement of the kidney is extremely rare. We report a case of a MALT lymphoma involving the kidney and the renal pelvis. A 56-year-old man presented with a history of hematuria and left flank pain. A computed tomography scan showed a marked tissue densification in the renal sinus, suggesting marked thickening of the urothelium, conditioning deformity of the renal pelvis and calyces. A cystoscopy confirmed a 2-cm papillary lesion on the left lateral aspect of the bladder. The patient underwent laparoscopic radical nephoureterectomy and transurethral bladder resection. The pathological diagnosis was MALT lymphoma in the kidney and urothelial carcinoma of the bladder. The patient was referred to a hematologist and was free of disease at 20 months of follow up without additional treatment.

Renal mucosa-associated lymphoid tissue lymphoma: a case report and literature review

“…(10) MALT lymphomas can affect several anatomical sites and the appearance is usually preceded by an inflammatory process, mainly observed in the gastrointestinal tract, respiratory system, salivary glands, head and neck, thyroid, breast, gallbladder, cervix, and ocular adnexa. (3)(4)(5)(7)(8)(9)11,12) Revista Mexicana de URología ISSN: 2007-4085, Vol. 83, núm.…”

“…However, transformation to high-grade in the late course of the disease was reported in 8% of the patients. (5,13) Radiographic presentations may vary, as well as their clinical presentation. (14) There are no differences in terms of imaging diagnosis since it debuts as a renal mass.…”

“…(1,2) Renal involvement represents less than 1% of prevalence of MALT lymphomas. (3)(4)(5)(6) Pelstring et al reported the first case of renal MALT lymphoma in 1991 and Colovic first described primary renal MALT lymphoma in 1999. (7) They are one of the less aggressive lymphomas and often present as an indolent, localized disease and the treatment of these cases was heterogeneous, from surgical, chemotherapy, immunotherapy, to radiotherapy.…”