Mucormycosis: Ten-Year Experience at a Tertiary-Care Center in Greece

Petrikkos, George; Skiada, Anna; Sambatakou, Helen; Toskas, Aggelos; Vaiopoulos, G; Giannopoulou, Myrto; Katsilambros, Nicholas

doi:10.1007/s10096-003-1035-y

Cited by 122 publications

(116 citation statements)

References 16 publications

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“…Mucormycosis virtually always occurs in patients with defects in host defense and/or with increased available serum iron, although rare cases have been reported in apparently normal hosts (83,85,119). In most cases, the infection is relentlessly progressive and results in death unless treatment with a combination of surgical debridement and antifungal therapy is initiated promptly.…”

Section: General Principlesmentioning

confidence: 99%

Novel Perspectives on Mucormycosis: Pathophysiology, Presentation, and Management

2005

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Mucormycosis is a life-threatening fungal infection that occurs in immunocompromised patients. These infections are becoming increasingly common, yet survival remains very poor. A greater understanding of the pathogenesis of the disease may lead to future therapies. For example, it is now clear that iron metabolism plays a central role in regulating mucormycosis infections and that deferoxamine predisposes patients to mucormycosis by inappropriately supplying the fungus with iron. These findings raise the possibility that iron chelator therapy may be useful to treat the infection as long as the chelator does not inappropriately supply the fungus with iron. Recent data support the concept that high-dose liposomal amphotericin is the preferred monotherapy for mucormycosis. However, several novel therapeutic strategies are available. These options include combination therapy using lipid-based amphotericin with an echinocandin or with an azole (largely itraconazole or posaconazole) or with all three. The underlying principles of therapy for this disease remain rapid diagnosis, reversal of underlying predisposition, and urgent surgical debridement

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Section: General Principlesmentioning

confidence: 99%

Novel Perspectives on Mucormycosis: Pathophysiology, Presentation, and Management

2005

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“…Cutaneous disease may lead to necrotizing fasciitis, which has a mortality rate of 80%. However, isolated cutaneous zygomycosis has a favorable prognosis and low mortality rate if surgical debridement is done (19,26). The present cutaneous case had no predisposing factors other than trauma.…”

Section: Discussionmentioning

confidence: 66%

Evaluation of patients with zygomycosis

Kaya¹,

Çavuş²,

Turhan³

et al. 2014

Turk J Med Sci

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Conspicuous vegetation entities of pedogenic soils rich in cadmium and their diethylene triamine pentaacetic acid (DTPA)extractable Cd content (DCd) under the temperate continental and Mediterranean climatic conditions of western Anatolia were determined. Foliage of herbaceous plants and nearby soil samples was collected from 51 zinc mining areas. DCd content was found to reach 11.6%-16.2% of the total Cd content, indicating more extractability than in many other heavy metals. Growth chamber and nursery experiments were conducted with the seeds collected. Dactylis glomerata and Galium tenuissimum subsp. tenuissimum, both common in grazing lands, were found to be accumulating 23.5 mg Cd kg -1 and 22.3 mg Cd kg -1 dry matter, respectively, which are highly phytotoxic levels. Thlaspi praecox, known as a Cd-hyperaccumulating plant species, could not be successfully introduced into the Cd-rich mining soils under controlled conditions, suggesting genetic variation or inability to adapt. Volunteer species under controlled conditions included Poa bulbosa and Plantago lanceolata, both of which were potential Cd-hyperaccumulating candidates. Silene aegyptiaca and Silene vulgaris were other species commonly found around zinc mines and they were grown under controlled conditions without difficulty. However, Cd concentrations in the above-ground tissues of all species mentioned above were not over the 100 mg kg -1 dry matter threshold value for hyperaccumulating cadmium.

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“…The infected lesion fi rst appears as a erythematous patch which turns into a voilaceous patch followed by a black necrotic eschar due to ischaemic necrosis produced by angioinvasive property of mucormycosis. The infection results from inhalation of fungal spores through the nose which then spreads from the sinuses into the mouth and produces painful, necrotic ulceration of the hard palate [5,16]. The reported patient had nasal pain and congestion, pain in the right maxillary sinus area followed by an erythematous tender patch at the hard palate which subsequently led to development of a perforation with a black necrotic plug of tissue.…”

Section: Discussionmentioning

confidence: 99%

Hard palate perforation in acute lymphoblastic leukemia due to mucormycosis — a case report

Samanta

Senapati

Kumar

et al. 2009

Indian J Hematol Blood Transfus

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Palatal perforation can occur due to trauma, infection and malignancy. Mucormycosis is a rare opportunistic fungal infection caused by an organism of class zygomycetes. Rhinocerebral mucormycosis is the most common type of mucormycosis that typically starts in maxillary antrum in immunocompromised patients. Invasion of surrounding structures leads to necrotizing ulcer of the hard palate and ultimately leads to perforation. Here, we report a case of perforation of the hard palate due to mucormycosis in a eight years child having acute lymphoblastic leukemia (ALL), who was on prolonged chemotherapy and corticosteroid therapy. This case is being reported for its rarity. The aim of presenting this case report is to emphasize that the infection due to mucomycosis should be included in the differential diagnosis of hard palate perforation in ALL patients who are immunocompromised.

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Mucormycosis: Ten-Year Experience at a Tertiary-Care Center in Greece

Cited by 122 publications

References 16 publications

Novel Perspectives on Mucormycosis: Pathophysiology, Presentation, and Management

Novel Perspectives on Mucormycosis: Pathophysiology, Presentation, and Management

Evaluation of patients with zygomycosis

Hard palate perforation in acute lymphoblastic leukemia due to mucormycosis — a case report

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