Mucormycosis in hospitalized patients at a tertiary care center in Lebanon: a case series

Zein, Saeed El; El‐Cheikh, Jean; Zakhem, Aline El; Ibrahim, Dima; Bazarbachi, Ali; Kanj, Souha S.

doi:10.1007/s15010-018-1195-4

Cited by 15 publications

(9 citation statements)

References 27 publications

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“…Despite concordant studies showing an increase in mucormycosis around the world ( 8 – 13 ), it is still a relatively rare disease. Therefore, any commercially viable therapy must target all Mucorales especially in the absence of a reliable rapid assay to identify the species of the infecting fungus in patients with mucormycosis.…”

Section: Discussionmentioning

confidence: 99%

“…Notably, a study reviewing cases in India for the past five decades predicted a prevalence of 0.14 cases per 1000 population, which equates to ~200,000 cases per year ( 12 ). Most recently, the number of mucormycosis patients per 10,000 hospital admissions increased substantially between 2008 and 2017 from 0.47 to 1.18 in a hospital in Lebanon ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

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Anti-CotH3 antibodies protect mice from mucormycosis by prevention of invasion and augmenting opsonophagocytosis

et al. 2019

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Mucorales are fungal pathogens that cause mucormycosis, a lethal angioinvasive disease. Previously, we demonstrated that Rhizopus, the most common cause of mucormycosis, invades endothelial cells by binding of its CotH proteins to the host receptor GRP78. Loss of CotH3 renders the fungus noninvasive and attenuates Rhizopus virulence in mice. Here, we demonstrate that polyclonal antibodies raised against peptides of CotH3 protected diabetic ketoacidotic (DKA) and neutropenic mice from mucormycosis compared to mice treated with control preimmune serum. Passive immunization with anti-CotH3 antibodies enhanced neutrophil inlfux and triggered Fc receptor-mediated enhanced opsonophagocytosis killing of Rhizopus delemar. Monoclonal antibodies raised against the CotH3 peptide also protected immunosuppressed mice from mucormycosis caused by R. delemar and other Mucorales and acted synergistically with antifungal drugs in protecting DKA mice from R. delemar infection. These data identify anti-CotH3 antibodies as a promising adjunctive immunotherapeutic option against a deadly disease that often poses a therapeutic challenge.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-CotH3 antibodies protect mice from mucormycosis by prevention of invasion and augmenting opsonophagocytosis

et al. 2019

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“…More recently, mucormycosis has emerged as an important and deadly co-infection in India and some countries of the Americas [ 67 ]. Although reports on mucormycosis were published from some countries of the Arab region in the pre-COVID-19 era [ 68 ], there are no new reports since the beginning of the pandemic.…”

Section: The Covid-19 Pandemic: What Do We Know?mentioning

confidence: 99%

Challenges to Antimicrobial Stewardship in the Countries of the Arab League: Concerns of Worsening Resistance during the COVID-19 Pandemic and Proposed Solutions

et al. 2021

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The COVID-19 pandemic is expected to worsen the global problem of antimicrobial resistance (AMR). There is a heightened interest in understanding this effect and to develop antimicrobial stewardship (AMS) interventions accordingly to curb this threat. Our paper aims to evaluate the potential magnitude of COVID-19 on AMR and AMS with a focus on the countries of the Arab league, given the social, political, and economic environments. We also evaluate obstacles in applying the rational use of antibiotics, monitoring resistance trends in the midst of the pandemic, and evaluating the impact of the economic crisis in some countries. We aim to raise awareness about the potential effects of antibiotic overuse during the pandemic and to propose practical approaches to tackle this issue.

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“…The highest estimated rate was in Iran at 9.2 per 100,000 population [17], then in Iraq and Algeria at 0.2 per 100,000 [20,77]. In Lebanon, an average incidence of 0.83 cases/10,000 admissions (range 0-2.22) was seen over a 10-year period in hospitalized patients, in addition to 20% mucormycosis-related deaths [115]. As for Turkey, 223 cases occurred in hematological malignancies patients and 214 cases in patients with diabetic ketoacidosis [21].…”

Section: Mucormycosismentioning

confidence: 99%

Update on invasive fungal infections in the Middle Eastern and North African region

et al. 2020

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In the recent years, the epidemiology of invasive fungal infections (IFIs) has changed worldwide. This is remarkably noticed with the significant increase in high-risk populations. Although surveillance of such infections is essential, data in the Middle Eastern and North African (MENA) region remain scarce. In this paper, we reviewed the existing data on the epidemiology of different IFIs in the MENA region. Epidemiological surveillance is crucial to guide optimal healthcare practices. This study can help to guide appropriate interventions and to implement antimicrobial stewardship and infection prevention and control programs in countries.

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Mucormycosis in hospitalized patients at a tertiary care center in Lebanon: a case series

Abstract: The incidence of MCM has significantly increased over the past 10 years at our institution, most likely due to the increasing patient population at risk. Understanding the epidemiology of MCM in our setting would help guide antifungal therapy.

Cited by 15 publications

References 27 publications

Anti-CotH3 antibodies protect mice from mucormycosis by prevention of invasion and augmenting opsonophagocytosis

Anti-CotH3 antibodies protect mice from mucormycosis by prevention of invasion and augmenting opsonophagocytosis

Challenges to Antimicrobial Stewardship in the Countries of the Arab League: Concerns of Worsening Resistance during the COVID-19 Pandemic and Proposed Solutions

Update on invasive fungal infections in the Middle Eastern and North African region

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