Mucormycosis in a diabetic ketoacidosis patient

Vijayabala, G. Sree; Annigeri, Rajeshwari G; Sudarshan, Ramachandran

doi:10.1016/s2221-1691(13)60164-1

Cited by 28 publications

(30 citation statements)

References 9 publications

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“…Unfortunately, the nature of this relationship is unclear. Diabetics have been known to be more susceptible to infection; however, this is classically thought of in relation to uncontrolled blood glucose levels or ketoacidotic states that create a milieu for bacteria or fungi to proliferate . Hyperglycemia of ≥11.1 mmol/L (≥200 mg/dL) has been closely associated with reduced neutrophil activity .…”

Section: Discussionmentioning

confidence: 99%

Chronic invasive fungal sinusitis: characterization and shift in management of a rare disease

D’Anza

Stokken

Greene

et al. 2016

Int Forum Allergy Rhinol

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Section: Discussionmentioning

confidence: 99%

Chronic invasive fungal sinusitis: characterization and shift in management of a rare disease

D’Anza

Stokken

Greene

et al. 2016

Int Forum Allergy Rhinol

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“…As seen in case report of Vijaybala GS et al, fatal cases are encountered rarely caused by massive haemoptysis [5]. The mucorales cause necrosis of the bronchial wall from where they invade the pulmonary vessel wall causing rupture of these vessels into the necrotic bronchi causing asphyxiation [6].…”

Section: Resultsmentioning

confidence: 99%

Mucormycosis in a Diabetic Ketoacidosis Patient: A Case Report

Biradar

Patil

Kadeli

2016

JCDR

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A 55-year-old male presented to the hospital with fever and cough since the past one week. The fever was on and off with intermittent headache. He had been diagnosed with diabetes mellitus (DM) five years back for which he had taken oral hypoglycaemic which he discontinued after four months and has been on herbal therapy since.On admission the patient was afebrile (36.4degree), his pulse rate was 100 beats per minute and BP of 120/70 mmHg. Physical examination was normal, on auscultation of chest occasional coarse crepitations were found and rest of the systems was normal. Laboratory investigations revealed haemoglobin of 16.8 g/dL, total white blood cell of 28000 cells per cumm (80% neutrophil) and ESR of 50mm in first hour. Serum biochemistry showed creatinine 2.3mg/dL, blood glucose level was 374 mg/ dL, sodium 131 mmol/L, potassium 4.7 mmol/L. Urine analysis revealed a 1.5% glucose, ketone bodies, and albumin 2+. Chest radiograph showed left upper lobe homogenous opacity suggesting consolidation [Table/ Fig-1]. He was empirically started on ceftriaxone.His sputum was sent for analysis which showed fungal elements on KOH mount. Diagnostic nasal endoscopy showed extensive crests filling left nasal cavity and maxillary sinus which was suggestive of mucormycosis.The patient was started on insulin therapy and amphotericin B intravenously at 1.5mg/kg body weight for 21 days with oral fluconazole of 150mg daily for six weeks. Renal profile was ABSTRACTMucormycosis is the name given to several different diseases caused by fungi of the order mucorales. It is commonly seen in patients with decreased immunity like patients with chronic renal failure, organ transplantation, neutropenia and most commonly in those with poorly controlled diabetes. We present a case of 55-year-old diabetic man who presented with headache and fever diagnosed with pulmonary and maxillary sinus mucormycosis presenting as diabetic ketoacidosis.

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“…Early and prompt diagnosis of fungal orbital cellulitis is a matter of vital importance since this condition accounts for very high mortality in immunocompromised individuals, such as diabetic patients. In diabetic patients, the hyperglycemic state of the body favors fungal proliferation and decreases chemotaxis and phagocytic activity, thereby permitting the opportunistic fungi to thrive in an acid-rich environment [10][11][12]. Zygomycosis group of fungi, particularly Mucor, is more common in diabetic patients.…”

Section: Discussionmentioning

confidence: 99%

Curvularia lunata causing orbital cellulitis in a diabetic patient: An old fungus in a new territory

Narula¹,

Meena²,

Jha³

et al. 2020

CMM

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Background and Purpose: Rhinocerebral mycosis is a rapidly invasive infection in diabetic patients with an unfavorable course. Herein, we report a rare case of orbital cellulitis caused by Curvularia lunata following fungal rhinosinusitis in a diabetic male patient. Case report: A 35-year-old male with uncontrolled diabetes presented to the emergency department of our center with high-grade fever accompanied by chills and rigors, severe diffuse headache, and projectile vomiting with swelling and loss of vision in the right eye. The tissue sample from surgical debridement showed pigmented hyphae; in addition, Curvularia lunata was isolated in culture. Imaging was indicative of orbital extension. Therefore, the patient was diagnosed with fungal rhinosinusitis with orbital cellulitis. The patient was subjected to extensive surgical debridement, along with antifungals. Rhinosinusitis resolved; however, the loss of vision was irreversible. Conclusion: Orbital cellulitis is a very rare but life-threatening complication of fungal rhinosinusitis. Very few cases of orbital cellulitis following fungal rhinosinusitis have been reported in the literature. Early and prompt diagnosis can save the life of a patient.

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Mucormycosis in a diabetic ketoacidosis patient

Cited by 28 publications

References 9 publications

Chronic invasive fungal sinusitis: characterization and shift in management of a rare disease

Chronic invasive fungal sinusitis: characterization and shift in management of a rare disease

Mucormycosis in a Diabetic Ketoacidosis Patient: A Case Report

Curvularia lunata causing orbital cellulitis in a diabetic patient: An old fungus in a new territory

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