Mucormycosis following burn injuries: A systematic review

Dang, Justin; Goel, Pedram; Choi, Kyu-Myung; Massenzio, Erik; Landau, Mark J.; Pham, Christopher H; Huang, Scott C.-H.; Yenikomshian, Haig A; Spellberg, Brad; Gillenwater, T Justin

doi:10.1016/j.burns.2022.05.012

Cited by 4 publications

(14 citation statements)

References 53 publications

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“…In their 2022 systematic review of mucormycosis in burns patients, which included 46 studies totaling 114 patients, Dang et al . found that on average survivors had a TBSA of 46%, while non‐survivors had a TBSA of 65% ( P < 0.001) 3 …”

Section: Figmentioning

confidence: 96%

“…Effective treatment relies on prompt diagnosis and extensive serial debridements, combined with intravenous amphotericin B 4 . This is due to the angioinvasive nature of the disease, which leads to vessel thrombosis and impedance of antifungal penetrance, such that antifungal therapy alone is ineffective 3,4 . Mortality rates for burns patients with cutaneous zygomycosis range from 29% to 67%, depending on the location of disease, TBSA and fungal species 5 .…”

Section: Figmentioning

confidence: 99%

“…2 In their 2022 systematic review of mucormycosis in burns patients, which included 46 studies totaling 114 patients, Dang et al found that on average survivors had a TBSA of 46%, while non-survivors had a TBSA of 65% (P < 0.001). 3 Effective treatment relies on prompt diagnosis and extensive serial debridements, combined with intravenous amphotericin B. 4 This is due to the angioinvasive nature of the disease, which leads to vessel thrombosis and impedance of antifungal penetrance, such that antifungal therapy alone is ineffective.…”

mentioning

confidence: 99%

“…4 This is due to the angioinvasive nature of the disease, which leads to vessel thrombosis and impedance of antifungal penetrance, such that antifungal therapy alone is ineffective. 3,4 Mortality rates for burns patients with cutaneous zygomycosis range from 29% to 67%, depending on the location of disease, TBSA and fungal species. 5 There is a significant increase in mortality with axial disease (32%) as opposed to peripheral disease (15.5%), where only the extremities are involved.…”

mentioning

confidence: 99%

“…6 Peripheral disease often requires amputation as a life-saving procedure. 3,6 In patients with systemic disease, palliation may need to be considered. 6 In both our cases, cutaneous zygomycosis presented as patches of necrosis, which could easily be mistaken for dried blood.…”

mentioning

confidence: 99%

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Cutaneous zygomycosis: a poor prognostic indicator in burns patients

Bishay

Yeap

Wijewardana

et al. 2023

ANZ Journal of Surgery

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Section: Figmentioning

confidence: 96%

Section: Figmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Cutaneous zygomycosis: a poor prognostic indicator in burns patients

Bishay

Yeap

Wijewardana

et al. 2023

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Severe Fungal and Parasitic Infections in the Intensive Care Unit

Lakbar,

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2023

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Mucormycosis in a Severe Trauma Patient Treated with a Combination of Systemic Posaconazole and Topical Amphotericin B—Case Report

Keller,

Antoni,

Minarcikova

et al. 2023

Antibiotics

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Mucormycosis is an opportunistic infection affecting mainly immunocompromised hosts. Infection in immunocompetent patients is rare, but may occur typically in trauma or burn victims. We report on a previously healthy young man suffering devastating trauma from an agricultural accident with the subsequent development of a multifocal mucormycosis. Diagnosis was achieved by cultures obtained from non-healing wounds, some of them even covered by a macroscopic mold formation. Specific treatment was initiated soon after the preliminary results indicated mucormycosis. Aggressive surgical therapy, with concomitant use of systemic posaconazole and topical amphotericin B in a combination treatment, led to the elimination of the fungal infection. The remaining deep tissue defects were consequently reconstructed by a muscle flap and skin graft autotransplantation with a good overall outcome, which would not have been possible without the complete remission of mucormycosis. This case study presents the successful use of a combination treatment with systemic posaconazole and topical amphotericin B and underlines the importance of timely and aggressive surgical therapy.

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Mucormycosis following burn injuries: A systematic review

Cited by 4 publications

References 53 publications

Cutaneous zygomycosis: a poor prognostic indicator in burns patients

Cutaneous zygomycosis: a poor prognostic indicator in burns patients

Severe Fungal and Parasitic Infections in the Intensive Care Unit

Mucormycosis in a Severe Trauma Patient Treated with a Combination of Systemic Posaconazole and Topical Amphotericin B—Case Report

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