Mucormycosis: an unusual masquerader of an endobronchial tumour

Jaganathan, Venugopal; Madesh, Vijaya Prakash; Subramanian, Santhakumar; Muthusamy, Rajeshwari K; Mehta, Sarah

doi:10.1002/rcr2.488

Cited by 3 publications

(5 citation statements)

References 11 publications

(17 reference statements)

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“…Infection primarily occurs by inhalation of its spores and inoculation into the respiratory tract [7] . The spores of mucorales show minimal pathogenicity in immunocompetent hosts because the macrophages can kill spores by phagocytosis and oxidative killing mechanisms.…”

Section: Discussionmentioning

confidence: 99%

“…Diabetes mellitus, steroid therapy and renal insufficiency has been reported as major risk factors. Involvement of the primary bronchus was the most frequently involved location [2] , [4] , [7] , [8] , [9] , [11] . Bronchoscopically, they mimic a malignant lesion findings a with a gray-white mucoid material and surrounding mucosal edema and necrosis [12] .…”

Section: Discussionmentioning

confidence: 99%

“…Surgical treatment in the form of wedge resection, lobectomy, and pneumonectomy, in combination with antifungal therapy, has been associated with lower mortality rates and better outcomes [2] , [7] . Surgical resection should be done as soon as feasible to prevent dissemination and erosion into the vessels, resulting in potentially fatal massive hemoptysis [2] .…”

Section: Discussionmentioning

confidence: 99%

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Endobronchial mucormycosis diagnosed by fiberoptic bronchoscopy

Assal

Hussein

Mostafa

et al. 2023

IDCases

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Endobronchial mucormycosis diagnosed by fiberoptic bronchoscopy

Assal

Hussein

Mostafa

et al. 2023

IDCases

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“…Occasional mucormycosis cases have been reported in the literature that masquerades a tumor and thus raises awareness of the varied presentation of this infection. 12,13 Yang et al 14 reported a case of pulmonary mucormycosis in a 45-year-old immunocompetent man mimicking lung carcinoma. Similarly, Malek et al 15 also reported a case of fatal disseminated mucormycosis mimicking malignancy.…”

Section: Discussionmentioning

confidence: 99%

Isolated cerebral mucormycosis masquerading as a tumor in an immunocompetent patient

et al. 2020

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Mucormycosis is an opportunistic fungal disease that commonly presents as cutaneous or rhinocerebral infections associated with immunocompromised states. It may exceptionally present as isolated involvement of the brain with a varied clinical presentation, which may be difficult to diagnose early, leading to increased mortality. Herein, we report the case of a 42-yearold immunocompetent female with left-sided limb weakness and a history of recurrent vomiting and headache for the last two years. Clinically, glioma was suspected, but histopathological examination revealed a few broad aseptate fungal hyphae. As no other organ was involved, the diagnosis of isolated cerebral mucormycosis was rendered. Reporting this case, we show an unusual presentation of a central nervous system mucormycosis masquerading a tumor in an immunocompetent patient. The case also highlights the importance of a careful histopathological examination to avoid missing the presence of occasional fungal hyphae. Ideally, recognition of fungal hyphae in the brain, during intraoperative consultation, can prompt brain tissue culture for definitive diagnosis and early empirical antifungal therapy, which may prove life-saving.

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“…2 Some unusual sites like colon-mucormycosis of colon mimicking carcinoma colon bronchus-mimicking as endobronchial tumour have been seen. 3,4 However, isolated mucormycosis of upper lip (labium superius oris) without any bony invasion has not been reported in literature to the best of our knowledge. Hence this poses a diagnostic challenge.…”

Section: Introductionmentioning

confidence: 99%

Labium superius oris mucormycosis: an enigma

Praveena

Mallineni

2023

Int J Otorhinolaryngol Head Neck Surg

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Mucormycosis is an aggressive opportunistic fungal infection affecting immunocompromised patients. It has six manifestations: rhinocerebral, pulmonary, cutaneous, gastrointestinal, disseminated and localized infection. However, isolated mucormycosis of upper lip (labium superius oris) without any bony invasion has not been reported in literature to the best of our knowledge. Hence this poses a diagnostic challenge. A 50-year-old male came with left sided nasal pain and left sided nasal obstruction associated with very mild uniform swelling of upper lip of 24 months duration. He underwent FESS in a local hospital and was misdiagnosed as granulomatous origin probably Tuberculosis. Even on ATT the symptoms didn’t subside and hence presented to our hospital. On incisional biopsy deep fungal infection probably mucor was reported and he was put on tab Posaconazole 300 mg OD. On recurrent upper lip swelling, excision biopsy was done. HPE was reported as fibrocollagenous stroma interspersed by multiple non-caseating epitheloid granulomas with plenty of foreign body type of giant cells. PAS showed broad aseptate acute angled hyphal forms suggestive of mucor. The follow up clinical presentation of the patient was very satisfactory with complete regression of upper lip swelling and no damage to surrounding structures. The case report highlights the existence of localized form of mucormycosis without bony necrosis in immunocompetent patients which require minimal surgical intervention along with oral medical therapy rather than extensive debridement.

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Mucormycosis: an unusual masquerader of an endobronchial tumour

Cited by 3 publications

References 11 publications

Endobronchial mucormycosis diagnosed by fiberoptic bronchoscopy

Endobronchial mucormycosis diagnosed by fiberoptic bronchoscopy

Isolated cerebral mucormycosis masquerading as a tumor in an immunocompetent patient

Labium superius oris mucormycosis: an enigma

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