Mucormycosis an added burden to Covid-19 Patients: An in-depth systematic review

Shah, Naveed Nazir; Khan, Zaid; Ahad, Hashim; Elderdery, Abozer Y.; Alomary, Mohammad N.; Atwah, Banan; Alhindi, Zain; Alsugoor, Mahdi H; Elkhalifa, Ahmed M. E.; Nabi, Showket; Bashir, Showkeen Muzamil; Yaqub, Tahir; Rather, Gulzar Ahmed; Ansari, Mohammad Azam

doi:10.1016/j.jiph.2022.10.011

Cited by 12 publications

(11 citation statements)

References 149 publications

(199 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mucormycosis is a lethal fungal infection caused by the filamentous fungi classified under subphylum Mucoromycotina; Class Glomeromycetes; order mucorales (previously classified under class zygomycetes) [2]. Spores of these filamentous fungi are found in the air, dust, organic garbage and food.…”

Section: Discussionmentioning

confidence: 99%

“…Fungi of mucorales are well known about their angioinvasiveness causing tissue thrombosis and necrotic damage. In a recently systematic review contacted by Shah et al [2], it is claimed that mucormycosis is an added burden to COVID-19 patients. COVID-19 -associated Mucormycosis (CAM) is becoming more common over the world, but it is most prevalent among diabetics in India and China [3].…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, the culture of the sent tissue was negative for mucorales identification. Reportedly, tissue culture is susceptible to damage from shear stress lowering the sensitivity of this method, with false negative results in up to 50% of mucormycosis patients [2]. Brain T2weighted MRI image in Rhino-Orbito-Cerebral Mucormycosis, usually reveals CNS involvement which occurs most frequently (70%) due to contiguous spread from the paranasal sinuses and orbits [8].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A Diabetic Man in the Era of COVID-19

2023

Ann Case Report

View full text Add to dashboard Cite

A 71-year-old man with medical history of uncontrolled diabetes mellitus, admitted to COVID-19 clinic with SARS-CoV-2 PCR test positive and dyspnea. After a few days of hospitalization he had an abrupt deterioration with decreased consciousness, facial enema with purple blue discoloration, ptosis, proptosis, facial palsy and necrotic eschars in the oral cavity. Brain MRI and necrotic tissue sample biopsy were conducted. Although MRI images were suspicious of Rhino-Orbito-Cerebral-Mucormycosis, the diagnosis was set from histopathology findings with dermis subcutaneous fat tissue infiltration of the filaments fungi "mucor". The risk assessment of COVID-19 mucormycosis co-infection is a worrisome scenario for patients suffering from uncontrolled co-morbidities, such as diabetes mellitus.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Diabetic Man in the Era of COVID-19

2023

Ann Case Report

View full text Add to dashboard Cite

show abstract

“…The implications for mucormycosis are unclear, and the DPP9 ' s impact on COVID-19 severity could indirectly affect susceptibility. Further research is needed to understand its role in the immune response to Mucorales and its potential for treating mucormycosis [38] [Figure 3].…”

Section: Intersection Of Genetic Factors In Covid-19 and Mucormycosismentioning

confidence: 99%

Genetic Basis for Mucormycosis Progression in COVID-19 Patients: From Susceptibility to Severity

Muruganantham,

Veerabathiran

2024

Infect Dis Immun

View full text Add to dashboard Cite

The dynamics of COVID-19 and mucormycosis reveal a complex interplay of genetic factors that influence the susceptibility, severity, and immune responses. COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), exhibits an increased incidence of mucormycosis, particularly in individuals with comorbidities or corticosteroid therapy. Mucormycosis is a fungal infection that affects the sinuses, orbits, and lungs and demands timely intervention with antifungal medications and surgery because of its life-threatening nature. Research on the genetic underpinnings of this intersection has unveiled key insights into the pathogenicity of Mucorales. Breakthroughs in genetic tools have exposed virulence factors, such as the CotH protein family and high-affinity iron-uptake mechanisms. Genetic susceptibility is a pivotal element in identifying individuals at risk of developing COVID-19, facilitating early detection, and allowing for personalized treatment strategies. DPP9, MIF, and TYK2 are among the genes implicated in COVID-19 severity, emphasizing the intricate relationship between genetic makeup and viral response. The genetic landscape extends to viral entry mechanisms, thereby affecting infection efficiency. Specific polymorphisms in genes such as IFNAR2, OAS3, and TYK2 are associated with COVID-19 severity, indicating shared genetic bases between severe and hospitalized cases. Mucormycosis is genetically predisposed, particularly in immunocompromised individuals. The challenge lies in understanding the genetic factors influencing susceptibility and offering insights into pathogenesis and potential therapeutic avenues. Organ transplantation adds another layer, increasing susceptibility to infections such as COVID-19 and mucormycosis. The impact of immunosuppression on COVID-19 severity remains elusive, necessitating ongoing research on the immunological mechanisms. Despite the challenges posed by emerging SARS-CoV-2 variants, the intricate connection between genetic factors and the interplay of COVID-19 and mucormycosis presents an opportunity for personalized treatment, targeted interventions, and refined public health strategies.

show abstract

“…Mucormycosis is a severe opportunistic fungal infection that results in increased hospitalization and mortality in vulnerable population groups, such as immunocompromised and elderly individuals over the age of 65 years. The prevalence of mucormycosis has rapidly increased throughout the world, especially among people with COVID-19 [ 36 ]. Studies reveal that during the second wave of COVID-19 infection, India reported the maximum incidences of mucormycosis because the country has the maximum cases of diabetes mellitus, hypertension, and other metabolic deficiencies in aged populations compared to the world [ 37 ].…”

Section: Fungal Infections In Covid-19 Patientsmentioning

confidence: 99%

Post-COVID-19 Fungal Infection in the Aged Population

et al. 2023

View full text Add to dashboard Cite

Coronavirus disease 2019 (COVID-19) infection is currently a great cause of concern for the healthcare sector around the globe. SARS-CoV-2 is an RNA virus that causes a serious infection that is associated with numerous adverse effects and multiple complications associated with different organs and systems during its pathogenic cycle in humans. Individuals affected by COVID-19, especially elderly populations and immunocompromised people, are greatly vulnerable to opportunistic fungal pathogens. Aspergillosis, invasive candidiasis, and mucormycosis are widespread fungal coinfections in COVID-19 patients. Other fungal infections that are rare but are exhibiting increased incidence in the current scenario include infections caused by Pneumocystis jirovecii, Histoplasma sp., Cryptococcus sp., etc. By producing virulent spores, these pathogens increase the severity of the disease and increase the morbidity and fatality rates in COVID-19 patients globally. These infections generally occur in patients recovering from COVID-19 infection, resulting in rehospitalization. Older and immunocompromised individuals are at higher risk of developing opportunistic fungal infections. This review focuses on understanding the opportunistic fungal infections prevalent in COVID-19 patients, especially elderly people. We have also highlighted the important preventive methods, diagnostic approaches, and prophylactic measures for fungal infections.

show abstract

Mucormycosis an added burden to Covid-19 Patients: An in-depth systematic review

Cited by 12 publications

References 149 publications

A Diabetic Man in the Era of COVID-19

A Diabetic Man in the Era of COVID-19

Genetic Basis for Mucormycosis Progression in COVID-19 Patients: From Susceptibility to Severity

Post-COVID-19 Fungal Infection in the Aged Population

Contact Info

Product

Resources

About