Mucormicosis rinoorbitocerebral, un estudio retrospectivo de 7 casos

Gorjón, Pablo Santos; Pérez, Pedro Blanco; Caletrío, Alfredo Batuecas; Herrera, Ángel Muñoz; González, Fernando Sánchez; Cañibano, Rebeca de la Fuente

doi:10.1016/j.otorri.2009.07.001

Cited by 11 publications

(7 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The underlying illness, the time between the onset of the disease and the establishment of treatment, and the occurrence of cerebral ischemic events play a role in worse survival rates. 6 Factors favouring rapid recovery in our patients were early diagnosis and prompt commencement of treatment.…”

Section: Discussionmentioning

confidence: 62%

“…In the recent cases reported it was found to be due to suppurative parotitis or other parotid lesions but rarely as a result of parotid involvement due to mucormycosis. 6 In few patients we observed the involvement of parotid gland with mucormycosis that was proven by aspiration of fluid from the gland and found positive for fungal stains and culture. As a result of gland involvement facial nerve paralysis occurred.…”

Section: Discussionmentioning

confidence: 93%

“…If this happens, the dose should be decreased until kidney function recovers. 6 In our case we started the patients on amphotericin B conventional treatment due to the constraints of affordability. Patients improved considerably after the commencement of treatment.…”

Section: Discussionmentioning

confidence: 98%

“…The invasive form has high affinity for the arteries and grows along the internal elastic lamina, eventually penetrating the endothelium and cause thrombosis, stroke and extensive tissue necrosis. 6 Risk factors for the development of mucormycosis include DM with or without ketoacidosis, neutropenia, protein-calorie malnutrition, and iron overload with or without the use of deferoxamine. 2 There are two predisposing factors for the disease: metabolic acidosis and a deficit in the function of neutrophils and monocytes.…”

Section: Discussionmentioning

confidence: 99%

“…The pathogenesis of this disease is arterial invasion by the fungi themselves, causing thrombosis and tissue infarction. 6 Clinically rhino-orbito-cerebral mucor mycosis can be described as acute fulminating infection. Patients are usually present with nasal discharge, orbital cellulitis, facial pain, headache, fever, ophthalmoplegia, ptosis and proptosis.…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Institutional experience of mucormycosis over a period of 10 years - retrospective case series

Menezes

et al. 2014

Int J Adv Med

View full text Add to dashboard Cite

Mucormycosis is a group of destructive opportunistic mycosis caused by filamentous fungi of order mucorales. Mucormycosis is the 3 rd most common invasive mycosis in order of importance after candidiasis and aspergillosis in hematological and Allogeneic Stem Cell Transplantation (ASCT) patients. 1 These fungi will cause lethal infections in immunecompromised patients especially those with uncontrolled diabetes accompanied with keto-acidosis. 2 Invasive mucormycosis is characterized by the rapid development of tissue necrosis due to vascular invasion and subsequent thrombosis. Disease may manifest as rhino-orbital-cerebral, pulmonary, cutaneous, gastrointestinal, or disseminated forms. 3 In this retrospective study we evaluated the clinical characteristics and treatment outcome for mucormycosis cases. METHODS Charts of 60 patients with histopathologically confirmed diagnosis of mucormycosis treated at St. John's medical ABSTRACT Background: Mucormycosis is an invasive fungal infection seen in immunocompromised patients. Most common presentation is face or orbital pain, headache, lethargy, visual loss, proptosis, or palatal ulcer. Because of its angioinvasive properties, it can rapidly spread to intracranial tissues and orbit. It can lead to fatal complications such as blindness, intracranial infections, convulsions and even death. Aim of current study was to diagnose this condition; a high index of suspicion is required. Blackish crusts are characteristically seen and Potassium hydroxide (KOH) staining of these crusts can give a rapid diagnosis. Methods: Study Design was retrospective review of the charts. We reviewed the charts between January 2001 and December 2010 and compiled together 60 cases of mucormycosis. Results: The most common presentation was orbital cellulitis. Some patients presented with features of acute sinusitis. The most common cause of immunosuppression was diabetes mellitus. Patients were started on amphotericin. The prognosis was bad in 7 patients who lost vision and 8 patients died. Conclusion: Diagnosis in the early stage needs a high degree of suspicion. The underlying illness, the time between the onset of the disease and the establishment of treatment, and the occurrence of cerebral ischemic events play a role in worse survival rates.

show abstract

Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Institutional experience of mucormycosis over a period of 10 years - retrospective case series

Menezes

et al. 2014

Int J Adv Med

View full text Add to dashboard Cite

show abstract

A Case of Rhinoorbital Mucormycosis in a Leukemic Patient with a Literature Review from Turkey

et al. 2011

View full text Add to dashboard Cite

Mucormycosis (Zygomycosis) is a rare, invasive, opportunistic fungal infection of the paranasal sinuses, caused by a fungus of the order Mucorales. We report a case of rhinoorbital mucormycosis caused by Rhizopus oryzae in an acute lymphoblastic leukemia patient and review the 79 Mucormycosis cases reported in the last decade from Turkey. In our case, the diagnosis was made with endoscopic appearance, computerized tomography of the paranasal sinuses, and culture of the surgical materials. Following aggressive surgical debridement and parenteral amphotericin B therapy, the patient recovered completely. In Turkish literature, rhinocerebral manifestations were the most common form of the mucormycosis (64 cases), followed by pulmonary form (6 cases). The most common risk factor was hematologic malignancies (32 cases) and diabetes mellitus (32 cases), similar to those reported from the rest of the world. The etiologic agents responsible for the review cases were Rhizopus sp., Mucor spp., Rhizomucor spp., Rhizopus oryzae, Mucor circinelloides, and Lichtheimia corymbifera. Although various treatment modalities were used, amphotericin B was the mainstay of therapy. Mortality rate was found to be 49.4% in review cases. It seems that strong clinical suspicion and early diagnosis, along with aggressive antifungal therapy and endoscopic sinus surgery, have great importance for better prognosis in mucormycosis.

show abstract