Mucolytics for bronchiectasis

Crockett, Alan; Cranston, Josephine M; Alpers, J. H.; Latiner, Karen M

doi:10.1002/14651858.cd001289

Cited by 41 publications

(23 citation statements)

References 4 publications

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“…Compared with placebo, recombinant human DNase also showed no preventive effect against LRTI in bronchiectasis patients. Influenza-like symptoms were more common in the group receiving recombinant human DNase [252].…”

Section: Recommendationmentioning

confidence: 94%

“…The same is largely true for patients with bronchiectasis, where a systematic review included three trials, but could not aggregate their data in a meta-analysis [252]. Compared with placebo, high doses of bromhexine with antibiotics eased difficulty in expectoration (WMD -0.53; 95% CI -0.81--0.25) and reduced sputum production by day 16 (WMD -21.5%; 95% CI -38.9--4.1).…”

Section: Recommendationmentioning

confidence: 99%

See 1 more Smart Citation

Guidelines for the management of adult lower respiratory tract infections

Woodhead¹

2005

European Respiratory Journal

682

555

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Section: Recommendationmentioning

confidence: 94%

Section: Recommendationmentioning

confidence: 99%

Guidelines for the management of adult lower respiratory tract infections

Woodhead¹

2005

European Respiratory Journal

682

555

View full text Add to dashboard Cite

“…Hypertonic saline may provide an useful adjunct to physiotherapy [24]. The potential for recombinant human DNase to favorably influence symptoms in NCFB has not been tested in children [25], but it has been well studied in adults and there is no evidence of benefit [26]. The Cochrane database suggests that bromhexine is the only mucolytic so far shown to be beneficial in the treatment of NCFB exacerbations [25].…”

Section: Airway Pharmacotherapymentioning

confidence: 99%

Non-cystic fibrosis bronchiectasis

Neves

Guerra

Ponce

et al. 2011

Interactive CardioVascular and Thoracic Surgery

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Bronchiectasis is characterized by irreversible widening of the medium-sized airways, with inflammation, chronic bacterial infection and destruction of the bronchial walls. Exercise or inspiratory muscle training may improve quality of life and exercise endurance in people with non-cystic fibrosis bronchiectasis. Prolonged-use antibiotics improve clinical response rates, but may not reduce exacerbation rates or lung function. Surgery is often considered for people with extreme damage to one or two lobes of the lung who are at risk for severe infection or bleeding. In this review, the authors will focus on non-cystic fibrosis bronchiectasis, pointing out the differences in management when compared with the cystic fibrosis context, with special emphasis on surgical management.

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“…In addition, a recent systematic review failed to clearly establish any effects of these drugs on secretion transport. (30) Studies of bronchiectasis, principally those conducted in developing countries, represent attempts to gain a better understanding of…”

Section: Discussionmentioning

confidence: 99%

Adesividade e purulência de secreções respiratórias: implicações no transporte mucociliar em pacientes com bronquiectasias

et al. 2010

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Objective: To analyze and compare the transport properties of respiratory secretions, classified by selected parameters, in individuals with bronchiectasis unrelated to cystic fibrosis. Methods: We collected mucus samples from 35 individuals with bronchiectasis unrelated to cystic fibrosis. The samples were first classified by their surface properties (adhesive or nonadhesive), as well as by their aspect (mucoid or purulent). We then tested the samples regarding relative transport velocity (RTV), displacement in a simulated cough machine (SCM), and contact angle (CA). For the proposed comparisons, we used ANOVA models, with a level of significance set at 5%. Results: In comparison with nonadhesive samples, adhesive samples showed significantly less displacement in the SCM, as well as a significantly higher CA (6.52 ± 1.88 cm vs. 8.93 ± 2.81 cm and 27.08 ± 6.13° vs. 22.53 ± 5.92°, respectively; p < 0.05 for both). The same was true in the comparison between purulent and mucoid samples (7.57 ± 0.22 cm vs. 9.04 ± 2.48 cm and 25.61 ± 6.12° vs. 21.71 ± 5.89°; p < 0.05 for both). There were no significant differences in RTV among the groups of samples, although the values were low regardless of the surface properties (adhesive: 0.81 ± 0.20; nonadhesive: 0.68 ± 0.24) or the aspect (purulent: 0.74 ± 0.22; mucoid: 0.82 ± 0.22). Conclusions: The respiratory secretions of patients with bronchiectasis showed decreased mucociliary transport. Increased adhesiveness and purulence cause the worsening of transport properties, as demonstrated by the lesser displacement in the SCM and the higher CA.Keywords: Bronchiectasis; Mucus; Mucociliary clearance; Adhesiveness. ResumoObjetivo: Analisar e comparar as propriedades de transporte de secreções respiratórias, classificadas através de parâmetros selecionados, de indivíduos com bronquiectasias não secundárias à fibrose cística. Métodos: Foram avaliadas amostras de muco respiratório, classificadas como com propriedades de superfície adesivas ou não adesivas, assim como com aspecto mucoide ou purulento, de 35 participantes com bronquiectasias não secundárias à fibrose cística, quanto a velocidade relativa de transporte (VRT), deslocamento em máquina simuladora de tosse (MST) e ângulo de contato (AC). Para as comparações propostas, foram utilizados modelos de ANOVA, com nível de significância estabelecido em 5%. Resultados: Houve uma diminuição significativa no deslocamento em MST, assim como um aumento significativo no AC, das amostras adesivas quando comparadas às não adesivas (6,52 ± 1,88 cm vs. 8,93 ± 2,81 cm e 27,08 ± 6,13° vs. 22,53 ± 5,92°, respectivamente; p < 0,05 para ambos). O mesmo ocorreu na comparação entre as amostras purulentas e mucoides (7,57 ± 0,22 cm vs. 9,04 ± 2,48 cm e 25,61 ± 6,12° vs. 21,71 ± 5,89°; p < 0,05 para ambos). Não houve diferença na VRT entre os grupos, embora os valores estivessem diminuídos, independentemente da adesividade (adesivas: 0,81 ± 0,20; não adesivas: 0,68 ± 0,24) ou do aspecto (purulentas: 0,74 ± 0,22; mucoides: 0,82 ± 0,22) das a...

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Mucolytics for bronchiectasis

Cited by 41 publications

References 4 publications

Guidelines for the management of adult lower respiratory tract infections

Guidelines for the management of adult lower respiratory tract infections

Non-cystic fibrosis bronchiectasis

Adesividade e purulência de secreções respiratórias: implicações no transporte mucociliar em pacientes com bronquiectasias

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