Mucoepidermoid carcinoma of the bronchus: A case report and review of the literature

Granata, Claudio; Battistini, Elena; Tomà, Paolo; Balducci, T.; Mattioli, Girolamo; Fregonese, B; Gambini, Claudio; Rossi, Giovanni

doi:10.1002/(sici)1099-0496(199703)23:3<226::aid-ppul10>3.0.co;2-9

Cited by 52 publications

(51 citation statements)

References 32 publications

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“…The remainder arise in minor salivary glands of the buccal mucosa, lips, retromolar region, tongue, and lung. Primary pulmonary variants are very rare in adults, whereas in children, they constitute approximately 9% of all primary malignant lung neoplasms, hence representing the third most frequent primary malignancy of the lung in this age group [3,4].…”

Section: Index Wordsmentioning

confidence: 99%

t(11;19)(q21;p12∼p13.11) and MECT1-MAML2 fusion transcript expression as a prognostic marker in infantile lung mucoepidermoid carcinoma

Serra

Schackert

Mohr

et al. 2007

Journal of Pediatric Surgery

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Section: Index Wordsmentioning

confidence: 99%

t(11;19)(q21;p12∼p13.11) and MECT1-MAML2 fusion transcript expression as a prognostic marker in infantile lung mucoepidermoid carcinoma

Serra

Schackert

Mohr

et al. 2007

Journal of Pediatric Surgery

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“…Mucoepidermal carcinoma of the lung is a very rare malignant tumor that accounts for 0.1% to 0.5% of all pulmonary neoplasms, occurring even less frequently in infants and children [1,2]. Although mucoepidermal carcinoma is assumed to be a low-grade malignancy, some cases with fatal outcomes have been reported [3][4][5].…”

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confidence: 99%

Mucoepidermal carcinoma of the lung detected by positron emission tomography in a 5-year-old girl

Kinoshita

Shimotake

Furukawa

et al. 2005

Journal of Pediatric Surgery

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“…The tumour was believed to arise from excretory ducts of submucosal bronchial glands with a common origin of the salivary glands [7]. A recent cytogenetic study indicates that the t(11;19) may be associated with the mucoepidermoid phenotype [8].…”

Section: Discussionmentioning

confidence: 99%

“…Mucoepidermoid tumours of the lung are usually located in the main or segmental bronchi [2,4,6,8,9], with some cases occurring in central airways such as the trachea [7,10] or carina [1]. Histologically, MEC are classified as low-grade to high-grade carcinomas.…”

Section: Discussionmentioning

confidence: 99%

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An 11-yr-old male with pneumonia and persistent airway obstruction

Niggemann

Gerstner²,

Guschmann³

et al. 2002

European Respiratory Journal

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Case reportAt the age of 4 yrs the male child suffered from a Wilms-tumour of the right kidney treated by polychemotherapy (SIOP No. 9 for stage 1 using actinomycin and vincristin) and surgical removal. A year later, abdominal pain occurred and a local relapse of the Wilms-tumour was diagnosed. Further diagnostics revealed infiltration into the liver, diaphragm, and the thoracic wall. In addition, three lung metastases were found. The child received polychemotherapy again (according to protocol SIOP 93/01 for stage 4 using adriamycin, etoposide, carboplatin, ifosphamide) and radiotherapy of the lung, abdomen (15 Gray) and of the tumour site (35 Gray). The tumour could be resected. All follow-ups during the next 6 yrs showed remission and the child was healthy.At the age of 11 yrs, he presented with fever and cough. The chest radiograph showed an opacity of the left upper field ( fig. 1). Under the suspicion of pneumonia, antibiotic treatment was started. Due to bronchial obstruction, the child received low-dose inhaled steroids and b-adrenergic agents. Nonetheless, he still suffered from bronchial obstruction and intermittent fever. Pulmonary function measurement revealed a mixed restrictive and obstructive ventilation disorder (forced vital capacity 52%, forced expiratory volume in one second 49% and flow at 25% vital capacity 13% predicted). Computed tomography (CT) scan of the thorax (including radioopaque material) was performed ( fig. 2).For further diagnosis flexible bronchoscopy was performed, revealing a ball-shaped, soft, solid tumour deriving from the left upper lobe bronchus and bulging into the ostium of the left main bronchus ( fig. 3). In order to obtain a thorough diagnosis of the tumour, thoracic surgical intervention was performed. The histology of the tumour revealed typical findings ( fig. 4).

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Mucoepidermoid carcinoma of the bronchus: A case report and review of the literature

Cited by 52 publications

References 32 publications

t(11;19)(q21;p12∼p13.11) and MECT1-MAML2 fusion transcript expression as a prognostic marker in infantile lung mucoepidermoid carcinoma

t(11;19)(q21;p12∼p13.11) and MECT1-MAML2 fusion transcript expression as a prognostic marker in infantile lung mucoepidermoid carcinoma

Mucoepidermal carcinoma of the lung detected by positron emission tomography in a 5-year-old girl

An 11-yr-old male with pneumonia and persistent airway obstruction

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