Mucoepidermoid carcinoma of salivary gland origin.Classification, clinical-pathologic correlation, and results of treatment

Healey, William V.; Perzin, Karl H.; Smith, L. C.

doi:10.1002/1097-0142(197008)26:2<368::aid-cncr2820260219>3.0.co;2-k

Cited by 239 publications

(71 citation statements)

References 6 publications

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“…The modified Healey system is based on certain qualitative histological parameters. 14,15 In our study, we applied AFIP grading system and nine out of 13 MEC were reported as low grade, three cases as high grade and one case as intermediate grade. In the three cases of MEC of high grade, the consistent features were minimal intracystic component, presence of cellular atypia, necrosis and invasion by nests of tumour cell and they would be designated as high grade lesions in both AFIP and Brandwein systems.…”

Section: Mucoepidermoid Carcinomamentioning

confidence: 87%

The dynamics of diagnosis of salivary gland tumours: histopathology matters

et al. 2016

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INTRODUCTIONTumours of salivary glands are rare constituting less than one percent of all tumours and 3% to 10% of the neoplasms of head and neck region.1,2 They are a heterogeneous group of tumours and present distinct clinicopathological features. Parotid gland accounts for 80% of salivary gland tumors followed by submandibular gland (10-15%).3 Majority of the primary tumours of salivary glands are benign but diagnosis of malignant tumours pose many difficulties in routine practice due to a wide spectrum of entities with overlapping in morphology.The histopathological features are intricate and differences between different types are very subtle and as such many challenges are encountered in establishing histological diagnosis, classification and grading of salivary gland neoplasms. The present work is taken up to study the incidence of salivary gland tumours in our ABSTRACT Background: Tumours of salivary glands are rare neoplasms of head and neck region accounting for less than one percent of all tumours. Parotid gland accounts for majority of tumors followed by submandibular gland. As such many challenges are encountered in establishing histological diagnosis, classification, grading and management of salivary gland neoplasms. This study is taken up to study the incidence of salivary gland tumours in our institution and analyse histological criteria for diagnosis and grading systems in vogue for common malignant lesions.

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Section: Mucoepidermoid Carcinomamentioning

confidence: 87%

The dynamics of diagnosis of salivary gland tumours: histopathology matters

et al. 2016

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“…The clinical behavior of MEC has proved to be difficult to predict but correlations to tumor grade and stage have been reported [30][31][32][33].The histologic features that are most useful in predicting the aggressive nature of these tumors are: 1) a minor cystic component (less than 20%); 2) tumor necrosis; 3) neural invasion; 4) cellular anaplasia; and 5) brisk mitotic activity [29]. Based on the presence or absence of these features and the clinical behavior, MEC are classified as low, intermediate, and high grade.…”

Section: Mucoepidermoid Carcinomamentioning

confidence: 99%

Current Thinking on Malignant Salivary Gland Neoplasms

Arrangoiz¹

2013

JCTR

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Abstract:Malignant salivary gland neoplasms are rare, representing approximately 3% to 7% of all head and neck cancers. Contrasting from the more common mucosal head and neck cancers, which, in general, are ascribed to excessive tobacco, alcohol use, and more recently to viral infection, specific carcinogenic factors for malignant salivary gland growths have not been as clearly identified. Histologically, they represent a heterogeneous group of tumors. Forty histologic types of epithelial tumors of the salivary glands have been reported; some are exceedingly rare and may be the topic of only a few case reports. Salivary tumors can arise in the major salivary glands or in one of the minor salivary glands (predominantly mucus secreting glands), which are distributed throughout the upper aerodigestive. Most patients who develop malignant salivary gland tumors are in the sixth or seventh decade of life. FNA should be considered as part of the diagnostic evaluation but due to its varying sensitivities and specificities imaging modalities such as ultrasound, CT scans, and MRI should also be used as diagnostic adjuncts. Surgery is the primary modality for management of these tumors, nontraditional surgical approaches and instrumentation, as well as facial nerve monitoring, can be selectively utilized to try and decrease the morbidity associated with these surgical procedures. Adjuvant treatment is primarily achieved with radiation therapy. Chemotherapy continues to have a palliative role in the management of salivary gland tumors; however, research in this field is trying to identify a therapeutic role for chemotherapy in order to improve overall survival.

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“…The grading of MEC has evolved from a two-tiered system to a three-tiered system (6,(20)(21)(22)(23)(24).…”

Section: Mucoepidermoid Carcinomamentioning

confidence: 99%