Mucoepidermoid carcinoma of salivary gland origin: classification, clinical-pathological correlation, treatment results and long-term follow-up in 55 patients

Plambeck, K.; Friedrich, Reinhard E; Schmelzle, R.

doi:10.1016/s1010-5182(96)80045-x

Cited by 58 publications

(35 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Patients with a pathologic solid type of ACC are more likely to develop distant metastases and die of their disease should they live a long period of time after treatment [19]. There is a high rate of metastases associated with ACC of the submandibular gland, tongue and maxillary antrum with a rate of 47.1, 50 and 40% respectively; metastases of the palate region is associated with the lowest rate of distant metastases [17,21].…”

Section: Adenoid Cystic Carcinomamentioning

confidence: 99%

Distant Metastases from Salivary Glands Cancer

Bradley

2001

ORL

View full text Add to dashboard Cite

Patients who present with malignant salivary glands should at their initial assessment have an X-ray of the chest to exclude the possibility of distant metastases. Patients who have other symptoms, bone pain etc., should be appropriately investigated. The likelihood of patients developing distant metastases is associated with high-grade tumors, most commonly adenoid cystic carcinoma, high-grade mucoepidermoid carcinoma, salivary duct carcinoma and tumors sited in the submandibular gland, posterior tongue and pharyngeal tumors. Patients who have had a high-grade tumor treated and survived without locoregional recurrence have the same risk of developing distant metastases as those patients who have locoregional recurrence. Other histological types of salivary tumors are associated with a lower risk of developing distant metastases but a real risk remains lifelong. It is recommended that all patients who have a malignant salivary gland tumor treated, any histology, should be followed up and clinically assessed at least once every 12 months for life.

show abstract

Section: Adenoid Cystic Carcinomamentioning

confidence: 99%

Distant Metastases from Salivary Glands Cancer

Bradley

2001

ORL

View full text Add to dashboard Cite

show abstract

“…The prognostic significance of the N-stage has also been highlighted in many previous reports. 3,4,[6][7][8][9][10]15 In contrast, the T-stage, its a-and …”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3]6,7,9,11 Even acinic cell carcinomas, which are considered as being 'low grade' can behave rather unpredictably and can have significant rates of regional metastasis and relapse. 10 The cases of LELC have been conventionally classified as being 'high grade' because of their poor histological differentiation.…”

Section: Histological Typementioning

confidence: 99%

“…Postoperative radiotherapy is indicated when the resection margin is positive or close, 3,4 the tumour is high grade, 3,4 there is tumour infiltration of adjacent organs, or regional metastasis is extensive. 5,6 The prognosis depends on the stage [5][6][7][8] and grade 3,4,9 of the cancer, the completeness of surgical resection, and, when the resection is incomplete, whether or not postoperative radiotherapy is administered. [1][2][3]6,10 Unlike other high-grade salivary gland carcinomas, lymphoepithelioma-like carcinomas (LELCs) are very radiosensitive, [11][12][13] and radiotherapy has been used instead of surgery as the primary treatment of LELC.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Salivary Gland Carcinoma

Mehanna¹,

Ang²

2012

Head and Neck Cancer Recurrence

View full text Add to dashboard Cite

Objectives. To investigate the failure patterns and the prognostic factors following postoperative radiotherapy for salivary gland carcinoma. Design. Retrospective study. Setting. University teaching hospital, Hong Kong. Patients. Fifty patients who had non-disseminated salivary gland carcinoma and who received primary treatment from 1984 through 1993. Main outcome measures. Demographic data, cancer T-and N-stages, histological type, site of origin, completeness of surgery, whether postoperative radiotherapy was given, and the clinical outcome. Results. Two (4%) patients had been treated with radiotherapy alone, six (12%) had undergone radical resection alone, and 42 (84%) had been radically treated by using both modalities. The 5-year overall survival and relapse-free survival rates were 78.4% and 63.1%, respectively. The free from local failure and free from distant metastasis rates at 5 years were 77.2% and 72.8%, respectively. The N-stage was a significant prognostic factor. The site of the primary tumour, T-stage, completeness of surgery, and use of postoperative radiotherapy were not significant independent prognosticators; however, among the T-stage tumours, the b-substage carcinomas had significantly fewer local failures (P=0.040) and better survival rates (P=0.038) than the a-substage carcinomas. There were seven (14%) locoregional failures without distant metastasis, seven (14%) cases of distant metastasis without locoregional failures, and four (8%) locoregional failures preceding distant metastasis; isolated regional relapse was rare (1/50; 2%). All regional failures (5/50; 10%) occurred ipsilateral to the primary lesion. There were no deaths due to lymphoepithelioma-like carcinoma or acinic cell carcinoma. Conclusions. The N-stage is the main prognostic factor of overall survival, relapse-and metastasis-free recovery, and success of treatment for salivary gland carcinoma. Optimal locoregional treatment can help reduce distant metastasis, and the maximal use of postoperative radiotherapy may contribute to improved locoregional control. Elective ipsilateral neck radiotherapy is indicated for lymphoepithelioma-like carcinoma.

show abstract

“…12,16,19,20 Radiographically the breast mass was suspicious for a primary lesion. It was the cytologic findings that led to the history rather than the reverse, which, in practice, is the more common scenario.…”

Section: Discussionmentioning

confidence: 99%