Mucoepidermoid carcinoma arising from a preexisting cyst of the liver

Hayashi, Itsuro; Tomoda, Hirotsugu; Tanimoto, Masanori; Furusawa, Motonosuke; Katsuda, Yasaburo; Shirai, Shigeo; Morimatsu, Minoru

doi:10.1002/jso.2930360210

Cited by 29 publications

(36 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some authors observed the remarkable neoplastic transformation of the normal duct lining epithelium, which suggested a possible of bile duct origination [16]. Some authors proposed that mucoepidermoid carcinoma of the liver might originate from a congenital cyst because the main tumors were located in the vicinity of multiple seromucinous cysts lined with columnar, cuboidal glandular epithelium with no connection to the biliary system and no bile content [8,11]. The electron micrographs revealed tonofilaments and confirmed the squamous nature of the tumor cells.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Unusual mucoepidermoid carcinoma of the liver misdiagnosed as squamous cell carcinoma by intraoperative histological examination

Guo

Yang

et al. 2014

Diagn Pathol

View full text Add to dashboard Cite

As rare condition, mucoepidermoid carcinoma may occur in liver although its etiology and pathogenesis is still unclear. We report here a case of intrahepatic mucoepidermoid carcinoma misdiagnosed as cholangiocarcinoma and squamous cell carcinoma by preoperative radiologic and intraoperative histological examinations, respectively. A 60-year-old woman presented with a 1-month history of progressive jaundice, epigastric discomfort, and weight loss with slightly increased carbohydrate antigen 19-9 (CA19-9). Computed tomography (CT) showed a large tumor, 8.0 cm in diameter, in the left lobe of the liver. A preliminary diagnosis of a cholangiocarcinoma of the liver was made. In the intraoperative histological examination, a diagnosis of squamous cell carcinoma was made based on predominantly invasive epidermoid cells with abundant keratinization and absence of mucin-producing cell component. However, postoperative histological diagnosis of the lesion was mucoepidermiod carcinoma of liver by thoroughly microscopical inspection and the presence of mucin-producing cells confirmed by Alcian blue staining. Despite surgical excision and chemotherapy, the tumor showed very aggressive malignancy with tumor recurrence. The patient died shortly afterward, surviving 6 months after surgery. Due to its rarity and distinct morphological features, mucoepidermoid carcinoma might be erroneously interpreted as squamous cell carcinoma by those who were not familiar with this condition in unusual locations. Therefore, removal of sufficient tissue from different portions of the lesion is essential for the surgeons and pathologists to make a precise diagnosis in the intraoperative histological examination.Virtual slideThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/4956311271136060

show abstract

Section: Discussionmentioning

confidence: 99%

“…Because of its relative rarity in liver, its etiology has not yet been elucidated. Terminal intrahepatic bile ducts or biliary congenital cysts have been proposed as a possible origin [5,7,8,11]. Histologically, mucoepidermoid carcinoma is characterized by squamoid (epidermoid), mucus producing and cells of intermediate type.…”

Section: Introductionmentioning

confidence: 99%

Unusual mucoepidermoid carcinoma of the liver misdiagnosed as squamous cell carcinoma by intraoperative histological examination

Guo

Yang

et al. 2014

Diagn Pathol

View full text Add to dashboard Cite

show abstract

“…It has been also reported that MEC may arise from preexisting congenital cysts [6, 7] in which the epithelium may transform into pluripotent intermediate cells, capable of differentiating into both mucin-secreting and squamous cells [6]. Similarly, Onoda et al demonstrated by electron microscopy that undifferentiated cells of the pancreatic duct showed multipotency [3].…”

Section: Discussionmentioning

confidence: 99%

Mucoepidermoid Carcinoma of the Intrapancreatic Common Bile Duct: Immunohistochemical Profile, Prognosis, and Review of the Literature

Moul

Bejarano

Casillas

et al. 2013

Case Reports in Pathology

View full text Add to dashboard Cite

Mucoepidermoid carcinoma of the bile duct is a rare entity. Only one mucoepidermoid carcinoma from the common bile duct has been reported in the Korean literature. Herein, we present the first in the English literature. The tumor arose in the intrapancreatic (distal) common bile duct in an 83-year-old woman who presented with obstructive jaundice and elevated liver enzymes. The tumor invaded the underlying pancreas and peripancreatic adipose tissue and showed pagetoid spread into the extrapancreatic common bile duct and cystic duct. The tumor exhibited nests of malignant cells with diffuse CK7 and MUC1 positivity. The basal cells were p63 and CK5/6 positive. The luminal cells were stained with carcinoembryonic antigen, MUC5, and mucicarmine and were focally positive for CK20. There was focal MUC4 staining on the apical luminal border. The neoplastic cells were negative for MUC2 and HER2-neu. We discuss the clinical presentation, diagnostic features, immunohistochemical profile, and prognosis of mucoepidermoid carcinoma of the common bile duct. The features of this neoplasm are further compared with mucoepidermoid carcinoma of the hepatobiliary system, adenosquamous carcinoma, and mucoepidermoid carcinoma of other organs.

show abstract

“…1,2,[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] The preoperative diagnosis was extremely difficult, with only three patients correctly diagnosed by aspiration cytology.…”

Section: Discussionmentioning

confidence: 99%

Primary adenosquamous carcinoma of the liver: case report

Suzuki

Hirai

Ota

et al. 2002

Journal of Hepato-Biliary-Pancreatic Surgery

View full text Add to dashboard Cite

We describe a case of adenosquamous carcinoma of the liver, including treatment for the recurrence. A 67-year-old man with prolonged high fever was diagnosed with a mass lesion in the left lobe of the liver seen by imaging studies. That mass lesion was histologically diagnosed as cholangiocarcinoma by needle biopsy. Left hepatic lobectomy was performed, and a tumor was found that measured 8.0 x 7.0 x 6.0 cm. It was a yellowish white solid mass without macroscopic invasion of the intrahepatic bile duct. Histological examination of the resected specimen revealed both adenocarcinoma and squamous cell carcinoma. The postoperative course was uneventful, but abdominal computed tomography 3 months after operation revealed seven masses in the remnant liver. We diagnosed recurrence of the tumor, and intrahepatic arterial infusion of cisplatin and 5-fluorouracil was begun. A partial remission resulted. Progression-free survival after chemotherapy lasted 2 months. However, the tumor markers and remnant tumor size increased gradually 9 months after the operation, and he died 14 months after surgery. We also review 41 cases of adenosquamous carcinoma of the liver reported in the Japanese and English language literature, including the present case.

show abstract

Mucoepidermoid carcinoma arising from a preexisting cyst of the liver

Cited by 29 publications

References 7 publications

Unusual mucoepidermoid carcinoma of the liver misdiagnosed as squamous cell carcinoma by intraoperative histological examination

Unusual mucoepidermoid carcinoma of the liver misdiagnosed as squamous cell carcinoma by intraoperative histological examination

Mucoepidermoid Carcinoma of the Intrapancreatic Common Bile Duct: Immunohistochemical Profile, Prognosis, and Review of the Literature

Primary adenosquamous carcinoma of the liver: case report

Contact Info

Product

Resources

About