Mucoepidermoid (adenosquamous) carcinoma arising in Barrett's esophagus

Pascal, Robert; Clearfield, Harris R.

doi:10.1007/bf01296298

Cited by 35 publications

(19 citation statements)

References 13 publications

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“…There are several opinions on the histogenesis of esophageal adenocarcinoma in man. One is ascribed to submucosal glands and ducts, and others to glandular metaplasia of squamous cell carcinoma, or to Barrett's esophagus [6,8,11]. However, the present feline tumor arose in the lowest third of the esophagus where esophageal glands are not observed in cats.…”

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confidence: 63%

Esophageal Adenosquamous Carcinoma in a Cat

Shinozuka

Nakayama

Uzuki

et al. 2001

The Journal of Veterinary Medical Science

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ABSTRACT. Esophageal carcinoma was observed in an eight-year-old, castrated male, Japanese domestic cat. Histologically, this neoplasm consisted of two different growth patterns, squamous cell carcinoma and adenocarcinoma. The results of immunohistochemical examination supported the fact that the two kinds of neoplastic cells have different characteristics. The tumor was, therefore, diagnosed as adenosquamous carcinoma. Esophageal tumors in the cat are very rare and, if any, neither adenocarcinoma nor adenosquamous carcinoma has been reported up to the present. KEY WORDS: adenosquamous carcinoma, esophagus, feline.J. Vet. Med. Sci. 63(1): 91-93, 2001 The esophageal tumors in animals are very rare expect for osteosarcoma and fibrosarcoma in dogs which may be caused by a helminth parasite (Spirocera lupi) [1,12]. The incidence of the esophageal tumors in cats is less than 0.5 percent of all alimentary tract neoplasms [7]. There are no literatures dealing with primary esophageal carcinoma in cats in Japan. The present report documents a case of esophageal carcinoma in a Japanese domestic cat.An eight-year-old, castrated male, Japanese domestic cat was presented to the Veterinary Medical Center of the University of Tokyo with complaints of bruxism, dysphasia, occasional vomiting, and regurgitation after eating and drinking. Radiographic examination revealed esophageal constriction at the lower thoracic part and irregular structures at the site. By computed tomography (CT) and esophagoscopic examinations, an intraluminal mass occupying esophageal lumen was found. The patient died due to general weakening.At necropsy, dilation of the lower portion of the thoracic esophagus just upper the constricted site was found. After opening the esophagus, a white polypoid nodular mass measuring 2 cm in diameter was noted on the mucosal surface at the site (Fig. 1). The esophageal lumen was occupied by the mass. The cut surface of the mass consisted of grayish white solid tissues and the esophageal wall beneath the mass was thickened (Fig. 2). Neither invasion to the surrounding tissues nor metastasis to other organs was found. No gross lesions were observed in the other organs except for several pulmonary abscesses (1 to 3 cm in diameter) and consolidation in the left anterior lobe.For light microscopic examination, the esophageal mass was fixed in 10% neutral buffered formalin and embedded in paraffin by a routine procedure. Four-µm-sections were stained with hematoxylin and eosin (HE) or Alcian blue-periodic acid-Schiff (AB-PAS). Immunohistochemical staining was also carried out using formalin-fixed paraffin sections by the avidin-biotin-peroxidase complex method (ABC kit, Vector Laboratories, Burlingame, CA, U.S.A.). The primary antibodies used were rabbit antiserum to human carcinoembryonic antigen (CEA) (DAKO, Carpinteria, CA, U.S.A.) and mouse monoclonal antibody to human keratin NCL-5D3 (BIO-SCIENCE Product, Gerlisstrasse, Switzerland). The latter is known as a glandular epithelial cell marker. For electron microscopic ...

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confidence: 63%

Esophageal Adenosquamous Carcinoma in a Cat

Shinozuka

Nakayama

Uzuki

et al. 2001

The Journal of Veterinary Medical Science

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“…While ASC and mucoepidermoid carcinoma have often been referred to interchangeably in the literature [20,21] , they are histologically distinct tumors. ASC features a well-defined border between the glandular and squamous components, while mucoepidermoid carcinoma features a homologous mixture of these cells [22] .…”

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confidence: 99%

Adenosquamous Carcinoma of the Esophagus: An NCDB-Based Investigation on Comparative Features and Overall Survival in a Rare Tumor

et al. 2017

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Objectives: Esophageal adenosquamous carcinoma (ASC) is a rare tumor with characteristics of adenocarcinoma (AC) and squamous cell carcinoma (SCC), the two most common esophageal cancers. Its behavior is aggressive but poorly understood. Using the National Cancer Database (NCDB), the clinical features and overall survival of ASC were compared with AC and SCC. Methods: The NCDB was queried for patients with esophageal ASC, AC, and SCC. Univariate association of histology with patient characteristics and overall survival were analyzed and socioeconomic characteristics were balanced. Results: Clinical M stage was 0 in a significantly lower proportion of ASC (69.0%) than in AC (70.9%) or SCC (75.6%) (p < 0.001). Median survival was lower in patients with ASC (9.6 months) than with AC (13.5) or SCC (9.7) and 2-year OS was lower in patients with ASC (23.8%) than with AC (34.6%) or SCC (26.5%) (p < 0.001). The OS hazard ratio for ASC was 1.14 when compared to AC (95% CI = 1.016-1.267, p = 0.025) and 1.10 when compared to SCC, but the latter was not significant (95% CI = 0.980-1.222, p = 0.111). Conclusion: ASC is a rare tumor among esophageal carcinomas with a greater burden of metastatic disease than AC or SCC and worse OS than AC.

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“…Most descriptions of this variant of esophageal cancer consist of case reports or small case series (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). While most reports from the western world are single cases, recently small case series have been reported from China and Japan (14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics of adenosquamous esophageal carcinoma

Yendamuri¹,

Malhotra²,

Hennon³

et al. 2017

J. Gastrointest. Oncol.

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Background: Current published information of adenosquamous carcinoma (ASC) of the esophagus in the United States is limited to isolated case reports. We sought to study the clinical characteristics of this tumor using the Surveillance, Epidemiology and End Results (SEER) database.Methods: Relevant data of all patients with esophageal cancer in the SEER database diagnosed from 1998-2010 was obtained. Demographic, grade, stage, treatment and survival characteristics of patients with ASC were summarized and compared to those patients with adenocarcinoma (ACA) and squamous cell carcinoma (SqCC). Univariate analyses across comparison groups were performed using Wilcoxon rank sum test for continuous covariates and the Pearson Chi-square test for categorical covariates. To evaluate the association of selected covariates to survival by histology, unadjusted and adjusted proportional hazards models were generated for the entire study population. To further control for the difference in covariates among the histology groups, propensity weighted Cox regression modeling was performed using the inverse propensity to treat weighting (IPTW) approach. Conclusions: ASC of the esophagus is a rare histological variant comprising 1% of esophageal ACA in the Unites States. This histological subtype presents in later stages, at a higher grade and portends a poorer survival than the more common ACA. Radiation therapy and surgical resection of appropriate stage patients provide the best chance of survival.

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Mucoepidermoid (adenosquamous) carcinoma arising in Barrett's esophagus

Cited by 35 publications

References 13 publications

Esophageal Adenosquamous Carcinoma in a Cat

Esophageal Adenosquamous Carcinoma in a Cat

Adenosquamous Carcinoma of the Esophagus: An NCDB-Based Investigation on Comparative Features and Overall Survival in a Rare Tumor

Clinical characteristics of adenosquamous esophageal carcinoma

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