Mucocutaneous manifestations in human immunodeficiency virus (HIV)‐infected patients in Nouakchott, Mauritania

Boushab, Boushab M.; Fall, F.; Maazouz, Mohamed V.; Savadogo, Mamoudou; Basco, Léonardo K.

doi:10.1111/ijd.13737

Cited by 14 publications

(16 citation statements)

References 22 publications

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“…e present research also found oral candidiasis to be a mucocutaneous disorder with significant association with low CD4 counts, which is consistent with previous studies [8,9,[21][22][23][24]. Furthermore, a statistically significant association was found between furuncle and low CD4 counts, which was compatible with Uthayakumar's research [25].Nevertheless, Ali Azfar et al could not show any association between skin manifestations and CD4 cell counts [20].…”

Section: Discussionsupporting

confidence: 92%

Mucocutaneous Manifestations in HIV-Infected Patients and Their Relationship to CD4 Lymphocyte Counts

et al. 2020

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Background. More than 90% of human immunodeficiency virus- (HIV-) infected patients show at least one mucocutaneous manifestation during the course of their disease. The frequency, pattern, and associated factors of these complications vary among different populations. Objective. This study was planned to evaluate the frequency of cutaneous presentations in HIV-infected patients and their association with the count of CD4 cells. Methods. A cross-sectional study was conducted on eighty-four HIV-positive patients, who attended the Behavior Consultation Center of Arak University of Medical Sciences. All subjects had a complete physical examination by an expert dermatologist. Further diagnostic procedures were performed, if necessary. Counts of CD4 were determined using flow cytometry. Results. From 84 patients who enrolled in this study, 95.2% manifested at least one type of mucocutaneous lesions. The most common presentation was xerosis, followed by seborrheic dermatitis, herpes simplex, and oral candidiasis. Oral candidiasis and furuncle were significantly associated with decrease in CD4 cell counts. Conclusions. Cutaneous manifestations are common in HIV-positive patients, some of which (oral candidiasis and furuncle) could be applicable as useful clinical indicators to predict the immune status of the patients. Therefore, regular skin examinations are recommended as routine HIV-infected patients’ healthcare programs.

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Section: Discussionsupporting

confidence: 92%

Mucocutaneous Manifestations in HIV-Infected Patients and Their Relationship to CD4 Lymphocyte Counts

et al. 2020

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“…Mucocutaneous manifestations are visible at any stage of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) in patients and are often the initial manifestations of HIV/AIDS . Mucocutaneous manifestations can be used as important clues to HIV/AIDS diagnosis and can reflect the immune status in patients . CD4 cell count is an important indicator of immune status in patients, and in HIV infection, CD4 cell as an important target cell reduced gradually with illness development .…”

Section: Introductionmentioning

confidence: 99%

Effects of CD4 cell count and antiretroviral therapy on mucocutaneous manifestations among HIV/AIDS patients in Yunnan, China

Wang

Tang

et al. 2019

Int J Dermatology

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Background The affecting factors of mucocutaneous manifestations in human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients remain unclear in China.Methods A retrospective analysis was conducted among HIV/AIDS patients in Yunnan, China. The demographic data, mucocutaneous manifestations, CD4 cell counts, and antiretroviral therapy (ART) regimens were collected. The effects of CD4 cell count and ART on the spectrum of mucocutaneous manifestations were evaluated.Results Among 508 HIV/AIDS patients, 86.0% of cases showed mucocutaneous manifestations. The average CD4 cell count (176 cells/ll) of the patients with manifestations was significantly lower than those without manifestations (328 cells/ll) (P < 0.001). Diseases such as herpes zoster, oral candidiasis, condyloma acuminatum, genital herpes, oral leukoplakia, talaromycosis, cryptococcosis, and HIV-PPE (pruritic papular eruption) were represented quite frequently in patients with CD4 cell count <200 cells/ll (P < 0.05), but eczema was suffered by those with CD4 cell count ≥200 cells/ll (P < 0.05). ART could decline the incidence of herpes zoster, oral candidiasis, condyloma acuminatum, genital herpes, oral leukoplakia, talaromycosis, and cryptococcosis (P < 0.05). Conclusions Mucocutaneous manifestations are closely related to the CD4 cell count and can be used as early predictors of HIV/AIDS and immune status in clinic. ART could reduce the incidence of certain mucocutaneous manifestations.

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“…En cuanto a la relación de las manifestaciones dermatológicas y conteo de CD4 hay mayor distribución en el grupo de 200-499 cel/μL Alcivar, 11 y mayor porcentaje de dermatosis < 200 cel/μL a CV Carrillo 10 similar a nuestro estudio. El estudio de Boushab, 6 Anand, 19 demuestran que las dermatosis se encuentran en mayor proporción < 200 cel/μL CD4, que discrepan con nuestros resultados, tal vez por una muestra reducida de dichos estudios (86 y 125 casos) y por la situación geográfica localizada en Mauritania e India, respectivamente.…”

Section: Discussionunclassified

“…5 En Mauritania, África, se evaluaron 86 pacientes mayores de 18 años, en quienes se encontró que un bajo conteo de células TCD4 (< 200 células/μL) se correlacionó significativamente con la presencia de infecciones por hongos como dermatofitosis y candidiasis oral. 6 En Cuba se evaluaron 117 pacientes VIH-SIDA en quienes la dermatosis más frecuente fue de origen infeccioso: viral y micótico. 7 En Ecuador en el periodo comprendido entre 1984-2010 se detalló una cifra de 18,739 casos confirmados de infección por el VIH.…”

Section: Wwwmedigraphicorgmxunclassified

Manifestaciones dermatológicas en pacientes VIH/SIDA acorde a la cuantificación de CD4 y carga viral

Santamaría-Burgos¹,

Oliva-Torres²,

Molina-Quimbita³

et al. 2019

Medicina Cutánea Ibero-Latino-Americana

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Mucocutaneous manifestations in human immunodeficiency virus (HIV)‐infected patients in Nouakchott, Mauritania

Cited by 14 publications

References 22 publications

Mucocutaneous Manifestations in HIV-Infected Patients and Their Relationship to CD4 Lymphocyte Counts

Mucocutaneous Manifestations in HIV-Infected Patients and Their Relationship to CD4 Lymphocyte Counts

Effects of CD4 cell count and antiretroviral therapy on mucocutaneous manifestations among HIV/AIDS patients in Yunnan, China

Manifestaciones dermatológicas en pacientes VIH/SIDA acorde a la cuantificación de CD4 y carga viral

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