Mucocutaneous histoplasmosis in HIV with an atypical ecthyma like presentation

Mehta, Vandana; De, Abhishek; Balachandran, C; Monga, Puja

doi:10.5070/d30r47h950

Cited by 6 publications

(2 citation statements)

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“…3,[6][7][8] Palatal perforation secondary to histoplasmosis has been reported only rarely. [9][10][11] Though common in North, central and south American countries, in India the Gangetic basin is endemic for histoplasma capsulatum. 12 Most cases have been reported from West Bengal, Rajasthan, Maharashtra, Haryana and Bihar.…”

Section: Discussionmentioning

confidence: 99%

Palatal perforation due to disseminated histoplasmosis as the first presentation of HIV-AIDS

Lakshmanan,

Radhika M,

Balan

et al. 2023

SAJCRR

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Histoplasmosis is a systemic fungal infection caused by H. capsulatum usually in immunocompromised individuals such as those with HIV-AIDS. Though oral manifestations are rare, they could be the only and initial manifestation of HIV-AIDS. We report the case of a 23-year-old female who presented with oral ulcer and palatal perforation and detected to be suffering from disseminated histoplasmosis. She also turned out to be HIV positive. Her CD4+ count was undetectable. She responded well to intravenous liposomal Amphotericin B, oral itraconazole and antiretroviral therapy. To the best of our knowledge, histoplasmosis presenting as palatal perforation as the first manifestation of HIV-AIDS has not been reported from South India previously. A high index of suspicion is needed in such cases of exaggerated oral lesions even in states like Kerala to avoid delay in diagnosis and therapy.

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Section: Discussionmentioning

confidence: 99%

Palatal perforation due to disseminated histoplasmosis as the first presentation of HIV-AIDS

Lakshmanan,

Radhika M,

Balan

et al. 2023

SAJCRR

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“… 5 - 22 Although rare, patients with AIDS and skin lesions but without lung involvement have also been reported recently. 5 - 8 Furthermore, an unusual orofacial case of manifestations of histoplasmosis in immunocompromised renal transplanted patient has also been described. 10 Therefore, our objective in presenting this case was to draw attention to the diagnosis of histoplasmosis among patients with skin lesions alone, in the absence of pulmonary involvement, because such cases can also evolve very rapidly to systemic infection, multiple organ failure and death, especially among patients with AIDS.…”

Section: Discussionmentioning

confidence: 99%

Histoplasmosis in the nasal septum without pulmonary involvement in a patient with acquired immunodeficiency syndrome: case report and literature review

et al. 2010

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CONTEXT: Histoplasmosis is a fungal disease caused by inhaling spores of the fungus Histoplasma capsulatum. The spores can be found in soil contaminated with bird, bat or chicken feces. Histoplasmosis occurs worldwide and is one of the most common pulmonary and systemic mycoses. CASE REPORT: We report here the case of a 37-year-old man with acquired immune deficiency syndrome and histoplasmosis in the nasal septum, without pulmonary involvement, that evolved rapidly to disseminated infection, multiple organ failure and death.

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HIV and the Skin

Bunker,

Piguet

2024

Rook's Textbook of Dermatology

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Within 2 years of defining acquired immune deficiency syndrome (AIDS) as a distinctive syndrome in 1981, human immunodeficiency virus (HIV) was identified as the causative agent. Dermatological involvement in AIDS has been appreciated since the disease was first recognised. Mucocutaneous involvement establishes criteria for diagnosis and staging; the prognostic significance of some complications, for example pruritic papular eruption/eosinophilic folliculitis, hairy leukoplakia and Kaposi sarcoma (KS), was well recognised before specific treatments were introduced. The proportion of patients with skin complications and the number of these manifestations in any one patient increase as HIV infection progresses and AIDS develops. The incidence and severity of several common cutaneous diseases (such as mollusca, herpes simplex and seborrhoeic dermatitis) are increased in patients with HIV and this correlates in many instances with the absolute numbers of CD4+ T cells. The effect HIV infection may have on some dermatological conditions such as psoriasis and leprosy is less clear‐cut. The advent of highly active combined antiretroviral therapy (ART) has been incalculably beneficial to patients with HIV, but novel side effects of these drugs (such as lipodystrophy) have emerged, and the skin can be affected by manifestations of the immune reconstitution inflammatory syndrome/immune reconstitution associated disease. The dermatological complications of HIV and AIDS may be distressing to patients and difficult for dermatologists to diagnose and manage. Also, many dermatoses presenting in the population at large need to be regarded as ‘indicator conditions’ to prompt advice about, and initiation of, HIV testing.

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Mucocutaneous histoplasmosis in HIV with an atypical ecthyma like presentation

Cited by 6 publications

References 0 publications

Palatal perforation due to disseminated histoplasmosis as the first presentation of HIV-AIDS

Palatal perforation due to disseminated histoplasmosis as the first presentation of HIV-AIDS

Histoplasmosis in the nasal septum without pulmonary involvement in a patient with acquired immunodeficiency syndrome: case report and literature review

HIV and the Skin

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