“…Since the first report of resistance to acyclovir in an immunocompromised, herpes simplex virus (HSV)-infected patient in 1982 (14), numerous other reports of resistance have been published (1, 6, 9, 11, 12, 22-24, 42, 53, 56, 58, 60, 69, 77). In the setting of patients with AIDS, resistance has clearly become clinically significant in HSV type 1 (HSV-1) and HSV-2 (2,7,8,27,33,50,55,61,63,65), cytomegalovirus (CMV) (4,19,25), and varicella-zoster virus (VZV) (35,40,46,57).…”