Mucociliary function deteriorates in the clinical range of inspired air temperature and humidity

Kilgour, Emma; Rankin, Nigel; Ryan, Stuart; Pack, R. J.

doi:10.1007/s00134-004-2235-3

Cited by 117 publications

(119 citation statements)

References 10 publications

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“…9 This preparation had several advantages over using the trachea as a tube. Reducing the distance over which the mucus is timed allows measurement of mucus-transport velocity over a few seconds.…”

Section: Discussionmentioning

confidence: 99%

“…9 We cut a sheep trachea lengthwise along the ventral midline, opened it, and, with minimal stretching, mounted it with pins over the bathing fluid container. It was held in place with a poly-methyl-methacrylate top that fit over the pins.…”

Section: Flat-mounted Trachea Preparationmentioning

confidence: 99%

“…8 Many methods have been used to measure non-cough mucus movement, including measuring the mass of the mucus as it appears at the output end of the system, and mucus-transport velocity, as an index of mucociliary efficiency. [9][10][11][12][13][14][15] Nonetheless, mucus-transport velocity does not indicate the total mass of mucus moved. To measure both mucus-transport velocity and mucus mass transport we developed a novel ovine trachea model designed to reproduce as closely as possible the situation in the in vivo trachea.…”

Section: Introductionmentioning

confidence: 99%

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Symmetrical-Waveform High-Frequency Oscillation Increases Artificial Mucus Flow Without Changing Basal Mucus Transport in In Vitro Ovine Trachea

Tatkov

Pack

2011

Respir Care

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BACKGROUND:The efficacy of symmetrical-waveform high-frequency oscillating (HFO) air flow for airway secretion clearance is controversial and debated in the literature. METHODS: We conducted in vitro experiments with ovine tracheae to investigate the effects of symmetrical-waveform HFO on tracheal transport of artificial mucus. We mounted each trachea as an intact tube, with a 15 o head-down tilt, infused artificial mucus (10 mL over one hour) at the caudal end of the trachea, and measured mucus-transport velocity as the time between the beginning of infusion and the first appearance of artificial mucus over 2 near-infrared sensors at the rostral end of the trachea and by measuring the amount of mucus emerging. In a second series of experiments we opened each trachea flat and with video microscopy we measured the transport velocity of plaques over the endogenous mucus sheet. RESULTS: In the intact-trachea preparation, HFO at 20 Hz and 50 cm H 2 O increased mucus-transport velocity from 5.8 mm/min to 7.8 mm/min. HFO led to nearly half the artificial mucus being cleared during the infusion period. In the opened-trachea experiments the mean control transport velocity was 8.7 mm/min, and HFO, at 14 Hz or 20 Hz (and 50 cm H 2 O), did not significantly alter that velocity. CONCLUSIONS: Symmetrical-waveform HFO increases mucus-transport velocity and mucus clearance when a thick layer of mucus is present. This may be important when considering the mechanisms of mucus clearance and using HFO for secretion clearance.

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Section: Discussionmentioning

confidence: 99%

Section: Flat-mounted Trachea Preparationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Symmetrical-Waveform High-Frequency Oscillation Increases Artificial Mucus Flow Without Changing Basal Mucus Transport in In Vitro Ovine Trachea

Tatkov

Pack

2011

Respir Care

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“…45,46 Care should be taken to quickly provide humidification to patients with artificial airways. Active humidifiers capable of quick warm-up and self-regulation (temperature and water levels) that require few disruptions offer many advantages.…”

Section: Airway Maintenance Humidificationmentioning

confidence: 99%

“…This reduction proceeded quickly to complete cessation. Complete cessation occurred much quicker at a temperature of 30°C, 46 in which most heat-and-moisture exchangers (HMEs) perform. Proper heating and humidification of inspiratory gas keeps the mucociliary ladder moving at a natural pace.…”

Section: Airway Maintenance Humidificationmentioning

confidence: 99%

Pediatric Airway Maintenance and Clearance in the Acute Care Setting: How To Stay Out of Trouble

2011

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1424RESPIRATORY CARE • SEPTEMBER 2011 VOL 56 NO 9Traditional airway maintenance and clearance therapy and principles of application are similar for neonates, children, and adults. Yet there are distinct differences in physiology and pathology between children and adults that limit the routine application of adult-derived airway-clearance techniques in children. This paper focuses on airway-clearance techniques and airway maintenance in the pediatric patient with acute respiratory disease, specifically, those used in the hospital environment, prevailing lung characteristics that may arise during exacerbations, and the differences in physiologic processes unique to infants and children. One of the staples of respiratory care has been chest physiotherapy and postural drainage. Many new airway clearance and maintenance techniques have evolved, but few have demonstrated true efficacy in the pediatric patient population. Much of this is probably due to the limited ability to assess outcome and/or choose a proper disease-specific or age-specific modality. Airway-clearance techniques consume a substantial amount of time and equipment. Available disease-specific evidence of airway-clearance techniques and airway maintenance will be discussed whenever possible. Unfortunately, more questions than answers remain.

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Effect of Postextubation High-Flow Nasal Cannula vs Conventional Oxygen Therapy on Reintubation in Low-Risk Patients

Hernández

Vaquero

González

et al. 2016

JAMA

446

357

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Mucociliary function deteriorates in the clinical range of inspired air temperature and humidity

Cited by 117 publications

References 10 publications

Symmetrical-Waveform High-Frequency Oscillation Increases Artificial Mucus Flow Without Changing Basal Mucus Transport in In Vitro Ovine Trachea

Symmetrical-Waveform High-Frequency Oscillation Increases Artificial Mucus Flow Without Changing Basal Mucus Transport in In Vitro Ovine Trachea

Pediatric Airway Maintenance and Clearance in the Acute Care Setting: How To Stay Out of Trouble

Effect of Postextubation High-Flow Nasal Cannula vs Conventional Oxygen Therapy on Reintubation in Low-Risk Patients

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