Mucocele-like tumor associated with ductal carcinoma in situ diagnosed as mucinous carcinoma by fine-needle aspiration cytology: report of a case

Kikuchi, Shoichi; Nishimura, Reiki; Osako, Tomofumi; Okumura, Yasuhiro; Hayashi, Mitsuhiro; Toyozumi, Yasuo; Arima, Nobuyuki

doi:10.1007/s00595-011-0063-y

Cited by 5 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is more difficult to make a definitive diagnosis in mucocele like tumors with concomitant atypical ductal hyperplasia or ductal carcinoma in situ, since the cellular polarity and atypia may be prominent, as in mucinous carcinoma. 2,10 Fat necrosis of the breast parenchyma may be misinterpreted as mucin. There is infiltration of histiocytes, multinucleated giant cells and degenerated RBCs in the intermediate stage of fat necrosis.…”

Section: Discussionmentioning

confidence: 99%

Pitfalls in cytological diagnosis of mucinous carcinomas of breast

Shivamurthy¹,

Jaiprakash²,

Vasudevan³

et al. 2021

IJPO

View full text Add to dashboard Cite

Introduction: Mucinous (colloid) carcinoma (MC) of the breast is relatively rare and accounts for 1-6% of all breast cancers. Traditionally, pure mucinous tumors and mixed infiltrating ductal carcinomas with a mucinous component have been described. Pure mucinous carcinoma of the breast has a favorable prognosis than the mixed variety noted in several studies. The common age of presentation is the postmenopausal group. Cytological diagnosis of these tumors is challenging. Materials and Methods: A retrospective study was conducted at our institute. 22 cases consisting of both mixed and pure mucinous carcinomas diagnosed by cytology and verified on histopathology between January 2007 and November 2015 were included in the study. All cytology and histopathology slides were reviewed.Results & Discussion: A total of 22 cases were evaluated. The age ranged from 34-78years. The left breast was involved in 12 cases and the right breast in 10cases. 19 cases were diagnosed as mucinous carcinoma on cytology. However 12 of these cases were reported as pure mucinous carcinoma on biopsy. All these cases displayed abundant mucin, small nuclei and/or regular nuclear outlines on cytology. 7 cases turned out to be mixed tumors on histopathology. Sparse mucin, large nuclei, irregular nuclear outlines or the presence of nucleoli were found in mixed mucinous carcinomas but not in pure tumors. Three cases were diagnosed as infiltrating ductal carcinoma (IDC) on cytology. One of these patients had 2 nodules, diagnosed on histopathological examination as IDC and mucinous carcinoma. Out of the other two cases, 1 case was diagnosed as cellular variant of mucinous carcinoma and another case as mixed carcinoma on biopsy. Cellular variant of mucinous carcinoma can mimic low grade ductal carcinoma on cytology. A thorough examination of the slides for mucinous material and few thin capillary fragments provide a valuable diagnostic clue. Conclusion:The distinction between pure and mixed mucinous carcinoma is important, because patients with the former type have a much favorable prognosis, with a low propensity for lymph node and distant metastasis. Cytopathological identification of patients with pure mucinous carcinomas may be performed only in a limited number of cases. The various differential diagnosis should always be kept in mind while dealing with lesions associated with mucin. However the age of presentation, clinical features and radiological findings can help to further categorize the various mucinous lesions.

show abstract

Section: Discussionmentioning

confidence: 99%

Pitfalls in cytological diagnosis of mucinous carcinomas of breast

Shivamurthy¹,

Jaiprakash²,

Vasudevan³

et al. 2021

IJPO

View full text Add to dashboard Cite

show abstract

“…Other diagnostic techniques, such as fine-needle aspiration cytology (FNAC), are less favored than CNB because of the smaller tissue sample and reduced structural information about the lesion. Reports of identical mucin makeup, similar cytological appearance, and difficult representative sampling of the whole lesion associated with FNAC of MLLs and mucinous carcinoma have led to the misdiagnosis of mucinous carcinoma in an MLL on at least one occasion [11]. There remains much uncertainty in diagnosing MLLs by CNB and FNAC, and the standard practice remains the excision of suspected lesions.…”

Section: Discussionmentioning

confidence: 99%

Mucocele-Like Lesion of the Breast

Dang¹,

Miles²,

Young³

et al. 2023

Cureus

View full text Add to dashboard Cite

Mucocele-like lesions (MLLs) of the breast are rare neoplasms characterized by dilated, mucin-filled epithelial ducts or cysts that can rupture and expel their contents into the surrounding stroma. They are frequently associated with atypia, dysplastic change, and, more recently, pre-malignant and malignant conditions like atypical ductal hyperplasia, ductal carcinoma, invasive carcinoma, or mucinous carcinoma. The malignant potential of MLLs is often challenging to determine from the initial histologic evaluation of a core-needle biopsy due to copious mucin and low cellularity. Therefore, at initial presentation, MLLs should be surgically excised and thoroughly evaluated for malignancy. In this paper, we present a rare case of an MLL and explore the radiology, histology, carcinogenic potential, diagnostic evaluation, and suggested management of the condition.

show abstract

“…Memenin mukosel benzeri lezyonu (MBL) 1986'da Rosen tarafından histolojik olarak memenin müsinöz karsinomuna benzeyen, ekstravaze müsin içeren benign bir lezyon olarak tarif edilmiştir (1). Daha sonraları duktal hiperplazi ya da karsinom ile ilişkili olarak da bildirilmiştir (2)(3)(4).…”

Section: Introductionunclassified

A Pathological Process Should be Carefully Conducted in the Breast: Mucocele-Like Lesion

Güçin¹

2018

Bezmialem Science

View full text Add to dashboard Cite

Memenin mukosel benzeri lezyonu (MBL) önceleri histolojik olarak memenin müsinöz karsinomuna benzeyen benign bir lezyon olarak tarif edilmiştir. Daha sonra duktal hiperplazi ya da karsinom ile ilişkili olarak da bildirilmiştir. Uzun dönem takiplerinde kanser riski bilinmemektedir. Bu nedenle perkutan meme biyopsisi ile tanı alan pür mukosel benzeri lezyonlara yaklaşım tartışmalıdır. Bu çalışmada 47 yaşındaki kadın hastada önce kor biyopside saptanan daha sonra eksize edilen materyalde insitu duktal karsinom alanlarının eşlik ettiği mukosel benzeri ekstravaze müsin varlığı ile karakterli lezyon sunulmuştur. Amaç, memede az görülen, bu nedenle de yanılgıya neden olabilen mukosel benzeri lezyonları ve çeşitliliklerini sunulan vaka eşliğinde gözden geçirmektir.

show abstract

Mucocele-like tumor associated with ductal carcinoma in situ diagnosed as mucinous carcinoma by fine-needle aspiration cytology: report of a case

Cited by 5 publications

References 13 publications

Pitfalls in cytological diagnosis of mucinous carcinomas of breast

Pitfalls in cytological diagnosis of mucinous carcinomas of breast

Mucocele-Like Lesion of the Breast

A Pathological Process Should be Carefully Conducted in the Breast: Mucocele-Like Lesion

Contact Info

Product

Resources

About