Mucoadhesive polymers in the design of nano-drug delivery systems for administration by non-parenteral routes: A review

Chitosan-coated diacerein nanosuspensions as a platform for enhancing bioavailability and lowering side effects: preparation, characterization, and ex vivo/in vivo evaluation

“…17 It was reported that surface coating of NDDS with mucoadhesive could provide additional advantages to NDDS such as protection against degradation, 18 localization of drug at the absorption window, 19 and sustaining drug effect. 20 Chitosan (CS) is a well-known cationic biodegradable polymer that was reported to enhance small intestine permeability. 21 Nanoparticles coated with the polysaccharide CS have attracted a special interest for mucoadhesive applications, mainly, because of its ability to interact with the negatively charged mucosal surface and to increase the absorption of drugs by reorganizing tight junctions (TJ) between mucosal cells.…”

The future of immunotherapy for canine atopic dermatitis: a review

“…Adjuvanting the allergen to enhance its delivery such as packaging in VLPs prior to injection, or in a mucoadhesive polymer to prolong oromucosal contact in SLIT, is promising. [38][39][40][41] Immunomodulating substances that direct the immune system towards a Th1 cell response and/or toleranceagain as a nonspecific action that could be administered along with any specific allergen -have been studied, but principally in mouse models. 42,43 Administration of CpG oligodeoxynucleotides either as sole therapy or along with specific allergen may have benefit, including in dogs.…”

Nanoparticular Drug Delivery Systems in the Treatment Central Nervous System Diseases: Review

“…Böyle güçlü bir immün yanıt bazı durumlarda aşırı duyarlılık ve anafilaksi gibi advers etkilere sebep olabilmektedir. 19,20 İmmün sistem hücrelerinin içerisine alındık-tan sonra NP'ler imflazom adı verilen ve inflamatuar yanıtı başlatan sitoplazmik multiproteinleri aktive edebilmektedir. Bu kompleksler inflamatuar sitokin prokürsörlerin proteolizini hızlandırmakta ve inflamatuar yanıtı oluşturacak gerekli biyoaktif mediyatörlerin salgılanmasını sağlamaktadır.…”

“…Mukoadezyon dışarıdan verilen madde ile nazal bölgenin epitelyal hücrelerini de içine alabilecek şekilde mukus tabakası ile yü-zeyler arasında etkileşimin olmasıdır. 20 Mukoadezyon sayesinde NP'ler mukozal yüzeyde daha uzun sure kalabilmektedir, böylece nazal absorpsiyon ve beyne geçiş daha hızlı olmaktadır. İntranazal uygulamadan sonra NP'lerin bölgede kalış süresini uzatmak için lektin ve buğday tohumu aglutinini gibi mukoadezif maddeler kullanılmaktadır.…”