Mucoadhesive Polymers: Gateway to Innovative Drug Delivery

Yaqoob, Muhammad; Jalil, Aamir; Bernkop‐Schnürch, Andreas

doi:10.1016/b978-0-12-821185-4.00020-8

Cited by 10 publications

(8 citation statements)

References 176 publications

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“…The residence time of the formulation in the absorption site is a crucial issue for buccal formulations aimed to produce systemic effects. One of the most attractive strategies for ensuring a proper and long-lasting retention of the formulation on the oral mucosa is based on the use of mucoadhesive polymers, capable of establishing molecular interactions with mucosa components, allowing a durable anchorage of the formulation [ 9 , 10 , 11 ]. Polymeric and lipid nanoparticles are suitable nanocarriers for buccal drug administration [ 12 , 13 ], and liposomes stand out for their high biocompatibility and versatility, allowing these lipid vesicles to be loaded with hydrophilic or hydrophobic drugs.…”

Section: Introductionmentioning

confidence: 99%

Development of a Mucoadhesive Vehicle Based on Lyophilized Liposomes for Drug Delivery through the Sublingual Mucosa

et al. 2022

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A pharmaceutical vehicle based on lyophilized liposomes is proposed for the buccal administration of drugs aimed at systemic delivery through the sublingual mucosa. Liposomes made of egg phosphatidylcholine and cholesterol (7/3 molar ratio) were prepared and lyophilized in the presence of different additive mixtures with mucoadhesive and taste-masking properties. Palatability was assayed on healthy volunteers. The lyophilization cycle was optimized, and the lyophilized product was compressed to obtain round and capsule-shaped tables that were evaluated in healthy volunteers. Tablets were also assayed regarding weight and thickness uniformities, swelling index and liposome release. The results proved that lyophilized liposomes in unidirectional round tablets have palatability, small size, comfortability and buccal retention adequate for sublingual administration. In contact with water fluids, the tablets swelled, and rehydrated liposomes were released at a slower rate than permeation efficiency determined using a biomimetic membrane. Permeability efficiency values of 0.72 ± 0.34 µg/cm2/min and 4.18 ± 0.95 µg/cm2/min were obtained for the liposomes with and without additives, respectively. Altogether, the results point to the vehicle proposed as a liposomal formulation suitable for systemic drug delivery through the sublingual mucosa.

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Section: Introductionmentioning

confidence: 99%

Development of a Mucoadhesive Vehicle Based on Lyophilized Liposomes for Drug Delivery through the Sublingual Mucosa

et al. 2022

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“…Glutaraldehyde (GA) obtained from Tianjin Kemiou Chemical Reagent Co., Ltd. (China) was used as the linkage agent. PVA was chosen as one of the green polymers widely used in medicine and water cleaning technologies 19. The PVA of such degree possesses optimal electrochemical properties and morphology suitable for membrane applications 20.…”

Section: Methodsmentioning

confidence: 99%

Removal of Phenol from Sour Water by Poly(vinyl Alcohol)/Polyamide‐Reverse Osmosis Membranes

et al. 2022

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A commercial thin‐film membrane (unmodified) of polyamide improved by poly(vinyl alcohol) (PVA)‐coated membranes (modified) was investigated for separating phenol in sour water by reverse osmosis. Dependences of pressure and pore surface area on flux and phenol rejection were tested. A graphical correlation was found between the relative flux decline and phenol concentration decrease in the feed. The modified membrane provided rejection of 86 % at 2 bar with the highest permeate flux of 8.46 L m−2h−1. The average contact angle for the former membrane was 58.4°, while that for the modified membrane was 49.1°. The reduction in contact angle enhances the surface hydrophilicity of the membrane leading to the antifouling effect. The modified membrane provides 95.4 % flux recovery compared to the unmodified membrane that provides only 66.2 %.

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“…PEG's ability to interpenetrate the mucus surface and a Michael-type addition reaction between a polymer's acrylate end group and a mucin-type glycoprotein's sulfide end group cause strong attachment to mucus. It has developed many additional multifunctional biomaterials for biotechnological and biomedical applications (Yaqoob, Jalil, and Bernkop-Schnürch 2021).…”

Section: Alginate-polyethylene Glycol Acrylate (Alginate-pegac)mentioning

confidence: 99%

Bioadhesive Drug Delivery Systems: A Review

Gad

Heikal²,

Hamadi³

2023

Records of Pharmaceutical and Biomedical Sciences

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The mucus layer covering the mucosal epithelial surface and mucin molecules interact with the bioadhesive drug delivery method to increase the time the formulations remain at the absorption site. The mucus layer covering the mucosal epithelial surface and mucin molecules interact with the bioadhesive drug delivery method to increase the time the dosage form remains at the absorption site. Bioadhesive formulations may be developed to provide sustained retention at the place of application and to give a controlled rate of medication release for greater therapeutic efficacy. Various factors, including the polymeric formulation's physicochemical properties and the mucosal tissue's content, influence the dosage form's ability to adhere to mucosal surfaces. This review covers the subjects of bio-adhesion mechanisms and theories, bio-adhesion polymers and polymers, various dosage forms and microbead manufacturing techniques.

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Mucoadhesive Polymers: Gateway to Innovative Drug Delivery

Cited by 10 publications

References 176 publications

Development of a Mucoadhesive Vehicle Based on Lyophilized Liposomes for Drug Delivery through the Sublingual Mucosa

Development of a Mucoadhesive Vehicle Based on Lyophilized Liposomes for Drug Delivery through the Sublingual Mucosa

Removal of Phenol from Sour Water by Poly(vinyl Alcohol)/Polyamide‐Reverse Osmosis Membranes

Bioadhesive Drug Delivery Systems: A Review

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